Results 171 to 180 of about 16,041 (210)

A potential role for sterol 27-hydroxylase in atherogenesis

Atherosclerosis, 2001
27-hydroxycholesterol is the product of the mitochondrial cytochrome P450 sterol 27-hydroxylase, a key enzyme in cholesterol metabolism present in most tissues of the body. 27-hydroxycholesterol increases in abundance with progression of human atherosclerotic lesions, therefore the aim of this study was to determine the pattern of sterol 27-hydroxylase
C M, Shanahan, K L, Carpenter, N R, Cary
openaire   +4 more sources

Sterol 27-hydroxylase Deficiency: A Rare Cause of Xanthomas in Normocholesterolemic Humans

Trends in Endocrinology & Metabolism, 2000
Cerebrotendinous xanthomatosis is characterized by the accumulation of cholestanol and cholesterol in xanthomas and brain causing a number of severe symptoms. More than 20 different mutations have been identified in the gene encoding sterol 27-hydroxylase.
I, Björkhem, E, Leitersdorf
openaire   +4 more sources

Transcriptional regulation of the human sterol 27-hydroxylase gene (CYP27) and promoter mapping

Atherosclerosis, 2001
Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a cluster of sites.
H, Segev, A, Honigman, H, Rosen, E, Leitersdorf   +3 more
openaire   +4 more sources

7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity

The Journal of Steroid Biochemistry and Molecular Biology, 2014
7-Dehydrocholesterol (7-DHC) is a common precursor of vitamin D3 and cholesterol. Although various oxysterols, oxygenated cholesterol derivatives, have been implicated in cellular signaling pathways, 7-DHC metabolism and potential functions of its metabolites remain poorly understood.
Kaori, Endo-Umeda, Kaori, Yasuda, Kazuyuki, Sugita, Akira, Honda, Miho, Ohta, Minoru, Ishikawa, Yuichi, Hashimoto, Toshiyuki, Sakaki, Makoto, Makishima   +8 more
openaire   +4 more sources

Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling

Neuroscience, 2009
Cholesterol is required in the brain for synaptogenesis and its turnover is critical for cerebral functions. Several proteins involved in cholesterol handling and metabolism are transcriptionally regulated by the nuclear liver X receptor (LXR) alpha and beta.
F. Gilardi, B. Viviani, A. Galmozzi, M. Boraso, S. Bartesaghi, A. Torri, D. Caruso, M. Crestani, M. Marinovich, E. de Fabiani   +9 more
openaire   +6 more sources

Down-regulation of the rat hepatic sterol 27-hydroxylase

The Journal of Steroid Biochemistry and Molecular Biology, 1999
Yi-Ping Rao, Z.Reno Vlahcevic, R.Todd Stravitz, Darrell H. Mallonee, Jayati Mullick, Narayan G. Avadhani, Phillip B. Hylemon   +6 more
openaire   +3 more sources

Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1996
The study objective was to determine whether and to what extent sterol 27-hydroxylase, the initial step in the "acidic" pathway of bile acid biosynthesis, is regulated by bile acids. Rats were fed diets supplemented with cholestyramine (CT, 5%), cholate (CA, 1%), chenodeoxycholate (CDCA, 1%), or deoxycholate (DCA, 0.25%).
Z R, Vlahcevic, S K, Jairath, D M, Heuman, R T, Stravitz, P B, Hylemon, N G, Avadhani, W M, Pandak   +6 more
openaire   +2 more sources

Maternal sterol 27-hydroxylase is crucial for securing fetal development

2023
SummaryThe maternal body helps in providing nutrients and degrading toxic metabolites instead of the fetal body; disruptions in these mechanisms affect normal fetal development. Sterol 27-hydroxylase (Cyp27a1) is involved in the alternative pathway of bile acid synthesis, which is enhanced during pregnancy.
Mitsuyoshi Suzuki, Satoshi Nakano, Natsumi Miharada, Hajime Takei, Pavan Prabhala, Mark van der Garde, Catharina Müller, Valgardur Sigurdsson, Maolake Aerken, Kiyoka Saito, Shuhei Koide, Gunilla Westergren-Thorsson, Mattias Magnusson, Genta Kakiyama, Hiroshi Nittono, Kenichi Miharada   +15 more
openaire   +1 more source

Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
It has recently been shown that extrahepatic cells can eliminate intracellular cholesterol by enzymatic conversion into 27-hydroxy-cholesterol and 3 beta-hydroxy-5-cholestenoic acid. Using immunohistochemical methods, we studied the presence of the enzyme responsible for these conversions, sterol 27-hydroxylase, in human carotid atherosclerotic plaques.
M, Crisby, J, Nilsson, V, Kostulas, I, Björkhem, U, Diczfalusy   +4 more
openaire   +2 more sources

Two novel mutations in the sterol 27‐hydroxylase gene causing cerebrotendinous xanthomatosis

Clinical Genetics, 2002
Cerebrotendinous xanthomatosis (CTX) is a rare recessive autosomal disease caused by mutations of the sterol 27‐hydroxylase gene. Clinically, CTX is characterized by tendon xanthomas, cataracts and progressive neurological deficits. Because of the disruption of the 27‐hydroxylase activity, CTX patients have elevated plasma levels of cholestanol, a by ...
S, Lamon-Fava, E J, Schaefer, R, Garuti, G, Salen, S, Calandra   +4 more
openaire   +2 more sources