Results 171 to 180 of about 9,389 (199)

Maternal sterol 27-hydroxylase is crucial for securing fetal development

2023
Summary The maternal body helps in providing nutrients and degrading toxic metabolites instead of the fetal body; disruptions in these mechanisms affect normal fetal development. Sterol 27-hydroxylase ( Cyp27a1 ) is involved in the alternative pathway of bile acid synthesis, which ...
Mitsuyoshi Suzuki, Satoshi Nakano, Natsumi Miharada, Hajime Takei, Pavan Prabhala, Mark van der Garde, Catharina Müller, Valgardur Sigurdsson, Maolake Aerken, Kiyoka Saito, Shuhei Koide, Gunilla Westergren-Thorsson, Mattias Magnusson, Genta Kakiyama, Hiroshi Nittono, Kenichi Miharada   +15 more
openaire   +1 more source

Mechanism of Accumulation of Cholesterol and Cholestanol in Tendons and the Role of Sterol 27-hydroxylase (CYP27A1)

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Objective — Tendon xanthomas are deposits of lipids and connective tissue commonly found in hypercholesterolemic patients. Macrophages are likely to be responsible for the lipid accumulation.
Sara, von Bahr, Tomas, Movin, Nikos, Papadogiannakis, Irina, Pikuleva, Per, Rönnow, Ulf, Diczfalusy, Ingemar, Björkhem   +6 more
openaire   +2 more sources

Functional analysis of the promoter of human sterol 27-hydroxylase gene in HepG2 cells

Gene, 2002
Human sterol 27-hydroxylase catalyses the first step in the alternative pathway of bile acids biosynthesis in hepatocytes. However the gene encoding this enzyme (CYP27 gene) is expressed in every tissue and some evidence suggests that this enzyme plays a role in cholesterol homeostasis.
GARUTI R, CROCE MA, PICCININI L, TIOZZO R, BERTOLINI, STEFANO, CALANDRA S.   +5 more
openaire   +3 more sources

Two novel mutations in the sterol 27‐hydroxylase gene causing cerebrotendinous xanthomatosis

Clinical Genetics, 2002
Cerebrotendinous xanthomatosis (CTX) is a rare recessive autosomal disease caused by mutations of the sterol 27‐hydroxylase gene. Clinically, CTX is characterized by tendon xanthomas, cataracts and progressive neurological deficits. Because of the disruption of the 27‐hydroxylase activity, CTX patients have elevated plasma levels of cholestanol, a by ...
S, Lamon-Fava, E J, Schaefer, R, Garuti, G, Salen, S, Calandra   +4 more
openaire   +2 more sources

Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
7-Ketocholesterol (7KC) is a major oxysterol found in atherosclerotic plaque and is believed to be derived both endogenously and exogenously (from the diet). Previously, we have demonstrated that subsequent to hepatic lipoprotein uptake, 7KC delivered in a model chylomicron remnant lipid emulsion is metabolised more rapidly and excreted into the ...
Malcolm A, Lyons, Nobuyo, Maeda, Andrew J, Brown   +2 more
openaire   +2 more sources

Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia.

Proceedings of the Association of American Physicians, 1998
We investigated the effect of sitosterol on hepatic sterol 27-hydroxylase activities in subjects with sitosterolemia, a recessive inherited disease associated with accelerated atherosclerosis and increased levels of sitosterol and other plant sterols and stanols in tissues.
L B, Nguyen, S, Shefer, G, Salen, S G, Tint, A K, Batta   +4 more
openaire   +1 more source

P0186 FATAL CHOLESTASIS IN INFANCY ASSOCIATED WITH MUTATION IN THE STEROL 27‐HYDROXYLASE GENE.

Journal of Pediatric Gastroenterology and Nutrition, 2004
B. Fischler, S. Von Bahr, I. Bj??rkhem, F. Van t???Hooft, G. Alvelius, A. Nemeth, J. Sj??vall   +6 more
openaire   +1 more source

Liver sterol 27 hydroxylase in hamster: Modulation by steroids and diets

Atherosclerosis, 2000
C. Lutton, M. Souidi, S. Dubrac, M. Parquet   +3 more
openaire   +1 more source

Transcriptional regulation of human sterol 27-hydroxylase gene in HepG2 cells

Atherosclerosis Supplements, 2001
R. Garuti, M.A. Croce, R. Tiozzo, S. Calandra   +3 more
openaire   +1 more source

Studies on the regulation of sterol 27-hydroxylase in monocyte-macrophages

Nutrition, Metabolism and Cardiovascular Diseases, 2003
openaire   +1 more source