Results 161 to 170 of about 9,389 (199)

Comprehensive proteome profiling of cytochrome P450 isoforms in cancer models. [PDF]

Clin Proteomics
Shaheed SU, Al-Eidan AA, Pors K, Patterson L, Sutton CW.   +4 more
europepmc   +1 more source

Gut Microbiota-Bile Acid Axis in Type 2 Diabetes-Associated Gallbladder Diseases: Mechanisms and Therapeutic Potential. [PDF]

Metabolites
Zhang Q, Jin Z.
europepmc   +1 more source

Integrated MALDI-MSI and UHPLC-OE-MS for Spatial Visualization and Biosynthetic Pathway Elucidation of Bioactive Metabolites in <i>Lilium lancifolium</i> Thunb. [PDF]

Molecules
Deng Q, Wang Z, Ji J, Xie M, Tong Q, Sun K, Peng Q, Yuan Z.   +7 more
europepmc   +1 more source

Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling

Neuroscience, 2009
Cholesterol is required in the brain for synaptogenesis and its turnover is critical for cerebral functions. Several proteins involved in cholesterol handling and metabolism are transcriptionally regulated by the nuclear liver X receptor (LXR) alpha and beta.
Barbara Viviani, Stefano Bartesaghi, A Torri   +2 more
exaly   +7 more sources

Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase

Journal of Internal Medicine, 2007
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase.
C -H Floren, Steve Meaney, Gösta Eggertsen   +2 more
exaly   +2 more sources

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Down-regulation of the rat hepatic sterol 27-hydroxylase

Journal of Steroid Biochemistry and Molecular Biology, 1999
Jayati Mullick, Narayan G Avadhani, Phillip B Hylemon   +2 more
exaly   +2 more sources

Mutation in the Sterol 27‐Hydroxylase Gene Associated with Fatal Cholestasis in Infancy

Journal of Pediatric Gastroenterology and Nutrition, 2005
Inborn errors of bile acid synthesis are rare but potentially treatable causes of neonatal cholestasis. We here present a cholestatic infant with an ongoing cytomegalovirus infection who despite intensive treatment died of severe liver disease at 4 months of age.The urinary steroids were investigated by electrospray mass spectrometry and gas ...
Sara, von Bahr, Ingemar, Björkhem, Ferdinand, Van't Hooft, Gunvor, Alvelius, Antal, Nemeth, Jan, Sjövall, Björn, Fischler   +6 more
openaire   +2 more sources

Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
It has recently been shown that extrahepatic cells can eliminate intracellular cholesterol by enzymatic conversion into 27-hydroxy-cholesterol and 3 beta-hydroxy-5-cholestenoic acid. Using immunohistochemical methods, we studied the presence of the enzyme responsible for these conversions, sterol 27-hydroxylase, in human carotid atherosclerotic plaques.
M, Crisby, J, Nilsson, V, Kostulas, I, Björkhem, U, Diczfalusy   +4 more
openaire   +2 more sources

Metabolism of an oxysterol, 7‐ketocholesterol, by sterol 27‐hydroxylase in hepG2 cells

Lipids, 2001
Abstract7‐Ketocholesterol (7K) is a quantitatively important oxysterol in both atherosclerotic lesions and macrophage foam cells. We reported recently that radiolabeled 7K delivered to rodents in a modified lipoprotein or chylomicron remnantlike emulsion, both cleared predominantly by the liver, was rapidly excreted into the intestine as water‐soluble ...
M A, Lyons, A J, Brown
openaire   +2 more sources

Sterol 27-hydroxylase Deficiency: A Rare Cause of Xanthomas in Normocholesterolemic Humans

Trends in Endocrinology & Metabolism, 2000
Cerebrotendinous xanthomatosis is characterized by the accumulation of cholestanol and cholesterol in xanthomas and brain causing a number of severe symptoms. More than 20 different mutations have been identified in the gene encoding sterol 27-hydroxylase.
I, Björkhem, E, Leitersdorf
openaire   +2 more sources