Results 161 to 170 of about 2,722,655 (194)

Metabolism of an oxysterol, 7‐ketocholesterol, by sterol 27‐hydroxylase in hepG2 cells

Lipids, 2001
Abstract7‐Ketocholesterol (7K) is a quantitatively important oxysterol in both atherosclerotic lesions and macrophage foam cells. We reported recently that radiolabeled 7K delivered to rodents in a modified lipoprotein or chylomicron remnantlike emulsion, both cleared predominantly by the liver, was rapidly excreted into the intestine as water‐soluble ...
M A, Lyons, A J, Brown
openaire   +2 more sources

Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997
It has recently been shown that extrahepatic cells can eliminate intracellular cholesterol by enzymatic conversion into 27-hydroxy-cholesterol and 3 beta-hydroxy-5-cholestenoic acid. Using immunohistochemical methods, we studied the presence of the enzyme responsible for these conversions, sterol 27-hydroxylase, in human carotid atherosclerotic plaques.
M, Crisby, J, Nilsson, V, Kostulas, I, Björkhem, U, Diczfalusy   +4 more
openaire   +2 more sources

Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase [PDF]

FEBS Journal, 1995
We have recently reported that coordinate down‐regulation of cholesterol 7α‐hydroxylase and sterol 27‐hydroxylase by bile acids results in suppression of bile acid synthesis in cultured rat hepatocytes [Twisk, J., De Wit, E. & Princen, H. M. G. (1995) Biochem. J. 305, 505–511].
Adriaan P IJzerman, Hans M Princen, Takashi Iida   +2 more
exaly   +3 more sources

Mechanism of Accumulation of Cholesterol and Cholestanol in Tendons and the Role of Sterol 27-hydroxylase (CYP27A1)

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Objective — Tendon xanthomas are deposits of lipids and connective tissue commonly found in hypercholesterolemic patients. Macrophages are likely to be responsible for the lipid accumulation.
Sara, von Bahr, Tomas, Movin, Nikos, Papadogiannakis, Irina, Pikuleva, Per, Rönnow, Ulf, Diczfalusy, Ingemar, Björkhem   +6 more
openaire   +2 more sources

Functional analysis of the promoter of human sterol 27-hydroxylase gene in HepG2 cells

Gene, 2002
Human sterol 27-hydroxylase catalyses the first step in the alternative pathway of bile acids biosynthesis in hepatocytes. However the gene encoding this enzyme (CYP27 gene) is expressed in every tissue and some evidence suggests that this enzyme plays a role in cholesterol homeostasis.
GARUTI R, CROCE MA, PICCININI L, TIOZZO R, BERTOLINI, STEFANO, CALANDRA S.   +5 more
openaire   +3 more sources

Two novel mutations in the sterol 27‐hydroxylase gene causing cerebrotendinous xanthomatosis

Clinical Genetics, 2002
Cerebrotendinous xanthomatosis (CTX) is a rare recessive autosomal disease caused by mutations of the sterol 27‐hydroxylase gene. Clinically, CTX is characterized by tendon xanthomas, cataracts and progressive neurological deficits. Because of the disruption of the 27‐hydroxylase activity, CTX patients have elevated plasma levels of cholestanol, a by ...
S, Lamon-Fava, E J, Schaefer, R, Garuti, G, Salen, S, Calandra   +4 more
openaire   +2 more sources

Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
7-Ketocholesterol (7KC) is a major oxysterol found in atherosclerotic plaque and is believed to be derived both endogenously and exogenously (from the diet). Previously, we have demonstrated that subsequent to hepatic lipoprotein uptake, 7KC delivered in a model chylomicron remnant lipid emulsion is metabolised more rapidly and excreted into the ...
Malcolm A, Lyons, Nobuyo, Maeda, Andrew J, Brown   +2 more
openaire   +2 more sources

Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia.

Proceedings of the Association of American Physicians, 1998
We investigated the effect of sitosterol on hepatic sterol 27-hydroxylase activities in subjects with sitosterolemia, a recessive inherited disease associated with accelerated atherosclerosis and increased levels of sitosterol and other plant sterols and stanols in tissues.
L B, Nguyen, S, Shefer, G, Salen, S G, Tint, A K, Batta   +4 more
openaire   +1 more source

Liver sterol 27 hydroxylase in hamster: Modulation by steroids and diets

Atherosclerosis, 2000
C. Lutton, M. Souidi, S. Dubrac, M. Parquet   +3 more
openaire   +1 more source

P0186 FATAL CHOLESTASIS IN INFANCY ASSOCIATED WITH MUTATION IN THE STEROL 27‐HYDROXYLASE GENE.

Journal of Pediatric Gastroenterology and Nutrition, 2004
B. Fischler, S. Von Bahr, I. Bj??rkhem, F. Van t???Hooft, G. Alvelius, A. Nemeth, J. Sj??vall   +6 more
openaire   +1 more source