Results 151 to 160 of about 2,722,655 (194)

Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling

Neuroscience, 2009
Cholesterol is required in the brain for synaptogenesis and its turnover is critical for cerebral functions. Several proteins involved in cholesterol handling and metabolism are transcriptionally regulated by the nuclear liver X receptor (LXR) alpha and beta.
Maurizio Crestani, Barbara Viviani, Stefano Bartesaghi   +2 more
exaly   +9 more sources

Cafestol, the Cholesterol-Raising Factor in Boiled Coffee, Suppresses Bile Acid Synthesis by Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase in Rat Hepatocytes

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Consumption of boiled coffee raises serum cholesterol levels in humans. The diterpenes cafestol and kahweol in boiled coffee have been found to be responsible for the increase.
Hans M Princen, Sabine M Post
exaly   +3 more sources

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A potential role for sterol 27-hydroxylase in atherogenesis

Atherosclerosis, 2001
27-hydroxycholesterol is the product of the mitochondrial cytochrome P450 sterol 27-hydroxylase, a key enzyme in cholesterol metabolism present in most tissues of the body. 27-hydroxycholesterol increases in abundance with progression of human atherosclerotic lesions, therefore the aim of this study was to determine the pattern of sterol 27-hydroxylase
Keri L. Carpenter, Catherine Shanahan, N R Cary   +2 more
exaly   +3 more sources

Down-regulation of the rat hepatic sterol 27-hydroxylase

Journal of Steroid Biochemistry and Molecular Biology, 1999
Narayan G Avadhani, R Todd Stravitz, Phillip B Hylemon   +2 more
exaly   +2 more sources

Transcriptional regulation of the human sterol 27-hydroxylase gene (CYP27) and promoter mapping

Atherosclerosis, 2001
Recent evidence suggests that sterol 27-hydroxylase may play a role in cholesterol homeostasis and affect atherogenesis. The major objective of the study was to map and characterize the sterol 27-hydroxylase (CYP27) promoter region. Here we show that CYP27 gene has a TATA-less promoter and transcription initiates at a cluster of sites.
Eran Leitersdorf, Alik Honigman, A Honigman   +2 more
exaly   +3 more sources

Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase

Journal of Internal Medicine, 2007
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase.
Ingemar Bjorkhem, Steve Meaney, C -H Floren   +2 more
exaly   +2 more sources

Mutation in the Sterol 27‐Hydroxylase Gene Associated with Fatal Cholestasis in Infancy

Journal of Pediatric Gastroenterology and Nutrition, 2005
Inborn errors of bile acid synthesis are rare but potentially treatable causes of neonatal cholestasis. We here present a cholestatic infant with an ongoing cytomegalovirus infection who despite intensive treatment died of severe liver disease at 4 months of age.The urinary steroids were investigated by electrospray mass spectrometry and gas ...
Sara, von Bahr, Ingemar, Björkhem, Ferdinand, Van't Hooft, Gunvor, Alvelius, Antal, Nemeth, Jan, Sjövall, Björn, Fischler   +6 more
openaire   +2 more sources

Sterol 27-hydroxylase Deficiency: A Rare Cause of Xanthomas in Normocholesterolemic Humans

Trends in Endocrinology & Metabolism, 2000
Cerebrotendinous xanthomatosis is characterized by the accumulation of cholestanol and cholesterol in xanthomas and brain causing a number of severe symptoms. More than 20 different mutations have been identified in the gene encoding sterol 27-hydroxylase.
I, Björkhem, E, Leitersdorf
openaire   +2 more sources

Maternal sterol 27-hydroxylase is crucial for securing fetal development

2023
Summary The maternal body helps in providing nutrients and degrading toxic metabolites instead of the fetal body; disruptions in these mechanisms affect normal fetal development. Sterol 27-hydroxylase ( Cyp27a1 ) is involved in the alternative pathway of bile acid synthesis, which ...
Mitsuyoshi Suzuki, Satoshi Nakano, Natsumi Miharada, Hajime Takei, Pavan Prabhala, Mark van der Garde, Catharina Müller, Valgardur Sigurdsson, Maolake Aerken, Kiyoka Saito, Shuhei Koide, Gunilla Westergren-Thorsson, Mattias Magnusson, Genta Kakiyama, Hiroshi Nittono, Kenichi Miharada   +15 more
openaire   +1 more source