Results 51 to 60 of about 16,062 (239)

17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle [PDF]

, 2016
Rationale & Aim: Estrogen and estrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of HCV life cycle is/are affected by estrogens.
Barbaglia, Matteo N., Boccato, Elisa, Burlone, Michela E., Cole, Sarah, Foglia, Chiara Z., Giarda, Paola, Grossini, Elena, Magri, Andrea, Minisini, Rosalba, Patel, Arvind H., Pirisi, Mario   +10 more
core   +2 more sources

Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia[S]

Journal of Lipid Research, 2017
Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD.
Hiten D. Mistry, Lesia O. Kurlak, Yosef T. Mansour, Line Zurkinden, Markus G. Mohaupt, Geneviève Escher   +5 more
doaj   +1 more source

Oxysterols and Their Cellular Effectors [PDF]

, 2012
Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain
Béaslas, Olivier, Nissilä, Eija, Olkkonen, Vesa M.   +2 more
core   +3 more sources

Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism

Journal of Pharmacy and Bioallied Sciences, 2011
It is well known that drug disposition and response are greatly determined by the activities of drug metabolizing enzymes, which are polymorphic.
Vera Dias, V Ribeiro
doaj   +1 more source

Molecular genetics of cerebrotendinous xanthomatosis in Jews of north African origin.

Journal of Lipid Research, 1994
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive sterol storage disease characterized by the accumulation of a bile alcohol, cholestanol, in diverse tissues.
A Reshef, V Meiner, V M Berginer, E Leitersdorf   +3 more
doaj   +1 more source

Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro

Viruses, 2023
Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble, Vishwanatha R. A. P. Reddy, Ben Jackson, Faisal R. Anjum, Chidiebere C. Ubachukwu, Ajit Patil, Shahriar Behboudi   +6 more
doaj   +1 more source

Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells.

Journal of Lipid Research, 1996
The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than
D A Winegar, J A Salisbury, S S Sundseth, R L Hawke   +3 more
doaj   +1 more source

Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

Journal of Lipid Research, 2004
There are two major pathways of bile acid synthesis: the “neutral” pathway, initiated by highly regulated microsomal cholesterol 7α-hydroxylase (CYP7A1), and an “alternative” pathway, initiated by mitochondrial sterol 27-hydroxylase (CYP27A1).
Shunlin Ren, Phillip Hylemon, Dalila Marques, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak   +6 more
doaj   +1 more source

Current trends in oxysterol research [PDF]

, 2016
In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius, Alwena H. Morgan, Andersson, Arnoldi, Bauman, Blanc, Clayton, Crick, de Medina, Diczfalusy, Dietschy, Eylan Yutuc, Fakheri, Gill, Goyal, Hannedouche, Heverin, Horton, Hu, Iuliano, Iuliano, Janowski, Jansen, Javitt, Jonas Abdel-Khalik, Klinke, Leonarduzzi, Liu, Lütjohann, Maarup, Meaney, Meljon, Murphy, Nelson, Ogundare, Porter, Radhakrishnan, Reboldi, Russell, Sacchetti, Santori, Schroepfer, Shackleton, Song, Soroosh, Theofilopoulos, Theofilopoulos, Thomas Hearn, Tint, Umetani, Wang, Wang, William J. Griffiths, Wu, Yuqin Wang   +54 more
core   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source