Results 71 to 80 of about 16,041 (210)
Journal of Lipid Research, 2001 Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem +7 more
doaj +1 more source
The Pathophysiology and Treatment of Hypertension in Patients With Cushing's Syndrome [PDF]
, 2019 When hypertension, a pathology that is frequently found in the general population, presents in a young patient, secondary causes such as Cushing's syndrome (CS), a rare disease characterized by long-term elevated cortisol levels, should be considered ...
Barbot, Mattia +2 more
core +1 more source
Experimental Physiology, Volume 111, Issue 5, Page 2627-2636, 1 May 2026.Abstract Although intravenous lipid emulsions are routinely administered to preterm infants, their specific effects on skeletal muscle development remain unclear. In this study, a soybean oil‐based lipid emulsion (Intralipid 20®) was administered via intravenous infusion to fetal sheep (gestational day 88–90) at a dose rising from 1 g/kg/day (day 0) to
Xinrui Li +5 more
wiley +1 more source
Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]
, 2004 Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Fischer, S. +5 more
core +1 more source
Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway [PDF]
, 2020 Diatoms are ubiquitous microalgae that have developed remarkable metabolic plasticity and gene diversification. Here we report the first elucidation of the complete biosynthesis of sterols in the lineage.
, Angela +7 more
core +1 more source
Mapping molluscan endocrinology: a systematic and critical appraisal
Biological Reviews, Volume 101, Issue 2, Page 970-1002, April 2026.ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis +3 more
wiley +1 more source
Сerebrotendinous xanthomatosis
Анналы клинической и экспериментальной неврологии, 2017 Cerebrotendinous xanthomatosis is a rare autosomal recessivedisorder of cholesterol and bile acid metabolism associated withthe sterol 27-hydroxylase gene CYP27A1.
G. E. Rudenskaya, E. Yu. Zakharova
doaj +1 more source
Cerebrotendinous xanthomatosis: Clinical and neuroimaging findings
Archives of Medicine and Health Sciences, 2020 Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of effective bile acid biosynthesis (adult lipid storage disorder with the underlying mutation in the CYP27 gene, which encodes sterol 27-hydroxylase, a key enzyme in the ...
S Sheetal, P Byju
doaj +1 more source
MedComm, Volume 7, Issue 4, April 2026.Ipriflavone (Ipr), an active component of Aquilaria malaccensis Lam. exosome‐like nanoparticles (AELNs), significantly reduces hypoxia‐inducible factor‐α (HIF‐α) expression by enhancing the prolyl hydroxylase domain protein 2 (PHD2)‐mediated hydroxylation of HIF‐α, thereby downregulating HIF‐α‐induced polyunsaturated fatty acid‐phospholipids (PUFA‐PLs),
Dezhi Wang +15 more
wiley +1 more source
Liver mitochondrial P450 involved in cholesterol catabolism and vitamin D activation.
Journal of Lipid Research, 1994 The isolation, purification, and cloning of the mitochondrial P450 enzyme catalyzing not only the 27-hydroxylation of 5 beta-cholestane-3 alpha, 7 alpha-diol and cholestane-3 alpha, 7 alpha, 12 alpha-triol, but also the 25-hydroxylation of vitamin D3 are
K I Okuda
doaj +1 more source