Results 71 to 80 of about 2,722,655 (194)
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang +4 more
wiley +1 more source
Journal of Lipid Research, 1996 An Italian subject with cerebrotendinous xanthomatosis (CTX) was found to have a partial deletion of the gene encoding the enzyme sterol 27-hydroxylase (CYP27 gene).
R Garuti +6 more
doaj +1 more source
Bile acid metabolism and signaling in human and animal health: A One Health perspective
iMetaOmics, Volume 3, Issue 3, September 2026.Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li +7 more
wiley +1 more source
The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway [PDF]
, 2009 © 2009 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Jacquier, N +10 more
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Journal of Lipid Research, 1996 The recognition that the 7 alpha-hydroxylation of 27-hydroxycholesterol is catalyzed by an enzyme that is different from cholesterol 7 alpha-hydroxylase raises the question as to the number of similar enzymes that may be present in liver and subserve ...
C Lee, K O Martin, N B Javitt
doaj +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 3, September 2026.Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley +1 more source
Antilithiasic effect of β-cyclodextrin in LPN hamster: comparison with cholestyramine
Journal of Lipid Research, 1999 β-Cyclodextrin (BCD), a cyclic oligosaccharide that binds cholesterol and bile acids in vitro, has been previously shown to be an effective plasma cholesterol lowering agent in hamsters and domestic pigs.
Nathalie Boehler +7 more
doaj +1 more source
Reviews in Aquaculture, Volume 18, Issue 4, September 2026.This manuscript systematically elucidates the molecular mechanisms underlying absorption, transport, and metabolism of Astaxanthin in aquatic animals, through the analysis of biological functions, transport proteins, and enzyme metabolism system. Furthermore, it outlines future molecular research strategies for Astaxanthin, providing a theoretical ...
Huakang Peng +12 more
wiley +1 more source
Journal of Lipid Research, 2003 Although the pool of cholesterol in the adult central nervous system (CNS) is large and of constant size, little is known of the process(es) involved in regulation of sterol turnover in this pool. In 7-week-old mice, net excretion of cholesterol from the
Chonglun Xie +4 more
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PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine
Journal of Lipid Research, 2007 Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li +2 more
doaj +1 more source