Results 81 to 90 of about 2,722,655 (194)

Loss of Rab8a‐Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia–Reoxygenation Injury

MedComm, Volume 7, Issue 8, August 2026.
Rab8a‐dependent tethering of lipid droplets to mitochondria sustains fatty acid oxidation and cardiomyocyte metabolic flexibility under normoxia. During hypoxia/reoxygenation, Rab8a loss and PLIN5‐associated lipophagy uncouple lipid breakdown from mitochondrial utilization, driving lipotoxicity and cell death.
Jialing Tang, Nathan Joyce, Thomas Laval, Eddie Tam, Hye Kyoung Sung, Mireille Ouimet, Gary Sweeney   +6 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Comparison of Cholesterol Lowering Diets: Apple, Casein Cytochrom P450 protein and Cholesterol 7α Hydroxylase Activities in Hamsters [PDF]

, 2010
Lithogenic diet, casein and apple fiber diets were fed to hamsters for 3-5 weeks. For control group, animals were fed on normal Purina chow without any supplement.
Rakesh Sharma, Rakesh K. Tandon, Rakesh Sharma, Rakesh Tandon   +3 more
core   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Sterol concentration and distribution in sunflower seeds (Helianthus annuus L.) during seed development [PDF]

, 2010
Sunflower seeds are currently used for edible oil production. Among oil minor compounds, phytosterols are of special interest due to their cholesterol reducing properties.
Merah, O, Mouloungui, Zephirin,, Alignan, Marion,, Alignan, Marion, M., Cerny, Muriel, M., Mouloungui, Zéphirin, Cerny, Muriel,, Merah, Othmane, Mouloungui, Zephirin, Z., Cerny, Muriel, Bouniols, Andrée, Alignan, Marion, Roche, Jane   +12 more
core   +1 more source

Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus

, 1995
We investigated the lobular localization and molecular level of expression of cholesterol 7α-hydroxylase and sterol 27-hydroxylase, two key enzymes in bile acid synthesis, in isolated periportal and pericentral hepatocytes and by in situ hybridization of
Moorman, A.F.M., Twisk, J., Mager, W.H., Gebhardt, R., Scheja, L., Princen, H.M.G., Hoekman, M.F.M., Boer, P.A.J. de   +7 more
core  

Fine-mapping, mutation analyses, and structural mapping of cerebrotendinous xanthomatosis in U.S. pedigrees

Journal of Lipid Research, 2001
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of bile acid biosynthesis. Clinically, CTX patients present with tendon xanthomas, juvenile cataracts, and progressive neurological dysfunction and can be diagnosed by the ...
Mi-Hye Lee, Starr Hazard, John D. Carpten, Sonia Yi, Jonathan Cohen, Glenn T. Gerhardt, Gerald Salen, Shailendra B. Patel   +7 more
doaj   +1 more source

A point mutation in the bile acid biosynthetic enzyme sterol 27-hydroxylase in a family with cerebrotendinous xanthomatosis.

Journal of Lipid Research, 1994
Cerebrotendinous xanthomatosis (CTX) is a rare familial disorder characterized by progressive neurological dysfunction, atherosclerosis, and xanthomas with sterol storage in the nervous system, vessels, and tendons.
N. Nakashima, Y. Sakai, H. Sakai, T. Yanase, M. Haji, F. Umeda, S. Koga, T. Hoshita, H. Nawata   +8 more
doaj   +1 more source

Effect of Dietary Cholesterol and Fat on the Expression of Hepatic Sterol 27-Hydroxylase and Other Hepatic Cholesterol-Responsive Genes in Baboons ( Papio Species)

, 1995
Our studies of baboons with low and high responses to dietary cholesterol and fat suggest that low-responding baboons increase the activity of hepatic sterol 27-hydroxylase, an important enzyme of bile acid synthesis, considerably more than do high ...
Henry C. McGill, Rampratap S. Kushwaha, Bharathi Guntupalli, K. Dee Carey, Karen S. Rice   +4 more
core   +1 more source