Results 101 to 110 of about 9,389 (199)

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression

, 2001
Fibrates are hypolipidemic drugs that affect the expression of genes involved in lipid metabolism by activating peroxisome proliferator-activated receptors (PPARs).
Kuipers, F; id_orcid, Princen, HMG, Staels, B, Post, SM, Duez, H, Gervois, PP   +5 more
core   +1 more source

Fine-mapping, mutation analyses, and structural mapping of cerebrotendinous xanthomatosis in U.S. pedigrees

Journal of Lipid Research, 2001
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of bile acid biosynthesis. Clinically, CTX patients present with tendon xanthomas, juvenile cataracts, and progressive neurological dysfunction and can be diagnosed by the ...
Mi-Hye Lee, Starr Hazard, John D. Carpten, Sonia Yi, Jonathan Cohen, Glenn T. Gerhardt, Gerald Salen, Shailendra B. Patel   +7 more
doaj   +1 more source

A point mutation in the bile acid biosynthetic enzyme sterol 27-hydroxylase in a family with cerebrotendinous xanthomatosis.

Journal of Lipid Research, 1994
Cerebrotendinous xanthomatosis (CTX) is a rare familial disorder characterized by progressive neurological dysfunction, atherosclerosis, and xanthomas with sterol storage in the nervous system, vessels, and tendons.
N. Nakashima, Y. Sakai, H. Sakai, T. Yanase, M. Haji, F. Umeda, S. Koga, T. Hoshita, H. Nawata   +8 more
doaj   +1 more source

25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles

Journal of Lipid Research, 2002
The CYP27 gene is expressed in arterial endothelium, macrophages, and other tissues. The gene product generates sterol intermediates that function as ligands for nuclear receptors prior to their transport to the liver for metabolism, mostly to bile acids.
Norman B. Javitt
doaj   +1 more source

Investigation into sterol signalling in Arabidopsis [PDF]

, 2009
The hydra sterol mutants (hydral and fk(^hyd2)) phenotypes are characterised by short thickened roots and a shoot consisting of a mass of indistinct leaves.
Cope-Selby, Naomi L.
core  

Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene

, 1998
Sterol 27-hydroxylase is important for the degradation of the steroid side chain in conversion of cholesterol into bile acids and has been ascribed a regulatory role in cholesterol homeostasis.
Rosen, Haim, Björkhem, Ingemar, Eggertsen, G., Reshef, A., Bjorkhem, I., Lippoldt, Andrea, Eggertsen, Gösta, Maeda, N., Triger, Liat, Rosen, H., Leitersdorf, E., Lippoldt, A., Shpizen, Shoshi, Leitersdorf, Eran, Shpizen, S., Reshef, Ayeleth, Triger, L., Maeda, Nobuyo   +17 more
core   +1 more source

Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1

Journal of Lipid Research, 1999
Oxysterol 7α-hydroxylase has broad substrate specificity for sterol metabolites and may be involved in many metabolic processes including bile acid synthesis and neurosteroid metabolism.
Zhengliang Wu, K.O. Martin, N.B. Javitt, J.Y.L. Chiang   +3 more
doaj   +1 more source

Sterol gene expression in Arabidopsis [PDF]

, 2009
Sterols are recognized as playing vital roles in plant development, as has been demonstrated from mutational studies. The study of the hydra mutants of Arabidopsis provides new tools to dissect sterol function in development at the molecular genetic ...
Liu, Dongbin
core  

Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source

Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages

, 2003
Sterol 27-hydroxylase has been suggested to be involved in an alternative pathway for the elimination of cholesterol from macrophages and early atherosclerotic lesions.
Schmitz, Gerd, Babiker, Amir, Hansson, Magnus, Ellis, Ewa, Hunt, Mary C   +4 more
core   +1 more source