Results 91 to 100 of about 2,722,655 (194)

25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles

Journal of Lipid Research, 2002
The CYP27 gene is expressed in arterial endothelium, macrophages, and other tissues. The gene product generates sterol intermediates that function as ligands for nuclear receptors prior to their transport to the liver for metabolism, mostly to bile acids.
Norman B. Javitt
doaj   +1 more source

Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene [PDF]

, 1998
Sterol 27-hydroxylase is important for the degradation of the steroid side chain in conversion of cholesterol into bile acids and has been ascribed a regulatory role in cholesterol homeostasis.
Rosen, Haim, Björkhem, Ingemar, Eggertsen, G., Reshef, A., Bjorkhem, I., Lippoldt, Andrea, Eggertsen, Gösta, Maeda, N., Triger, Liat, Rosen, H., Leitersdorf, E., Lippoldt, A., Shpizen, Shoshi, Leitersdorf, Eran, Shpizen, S., Reshef, Ayeleth, Triger, L., Maeda, Nobuyo   +17 more
core   +1 more source

Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1

Journal of Lipid Research, 1999
Oxysterol 7α-hydroxylase has broad substrate specificity for sterol metabolites and may be involved in many metabolic processes including bile acid synthesis and neurosteroid metabolism.
Zhengliang Wu, K.O. Martin, N.B. Javitt, J.Y.L. Chiang   +3 more
doaj   +1 more source

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression

, 2001
Fibrates are hypolipidemic drugs that affect the expression of genes involved in lipid metabolism by activating peroxisome proliferator-activated receptors (PPARs).
Kuipers, F; id_orcid, Princen, HMG, Staels, B, Post, SM, Duez, H, Gervois, PP   +5 more
core   +1 more source

Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source

Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes

, 1999
Lipoproteins may supply substrate for the formation of bile acids, and the amount of hepatic cholesterol can regulate bile-acid synthesis and increase cholesterol 7α-hydroxylase expression.
Fits, L. van der, Twisk, J., Mager, W.H., Wit, E.C.M. de, Post, S.M., Princen, H.M.G., Hoekman, M.F.M.   +6 more
core  

Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages [PDF]

, 2003
Sterol 27-hydroxylase has been suggested to be involved in an alternative pathway for the elimination of cholesterol from macrophages and early atherosclerotic lesions.
Schmitz, Gerd, Babiker, Amir, Hansson, Magnus, Ellis, Ewa, Hunt, Mary C   +4 more
core   +1 more source

Biosynthesis of the regulatory oxysterol, 5-cholesten-3β,25-diol 3-sulfate, in hepatocytes

Journal of Lipid Research, 2007
Cellular cholesterol homeostasis is maintained through coordinated regulation of cholesterol synthesis, degradation, and secretion. Nuclear receptors for oxygenated cholesterol derivatives (oxysterols) are known to play key roles in the regulation of ...
Xiaobo Li, William M. Pandak, Sandra K. Erickson, Yongjie Ma, Lianhua Yin, Phillip Hylemon, Shunlin Ren   +6 more
doaj   +1 more source

Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]

, 2004
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Thiessen, K., Parhofer, K. G., Fischer, S., Sauter, G. H., Jungst, D., Jungst, C.   +5 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source