Results 91 to 100 of about 9,389 (199)

917-96 In Vitro Inhibition of Smooth Muscle Cell Proliferation by Sterol 27-Hydroxylase Metabolites

, 1995
Sterol 27-hydroxylase controls side chain oxidation of bile acids and is found in vascular endothelial cells. Two metabolites of this oxidation are 27-hydroxycholesterol (27-OH), which inhibits smooth muscle cell (SMC) proliferation in vivo, and 3β ...
Reiss, A., Galloway, A.C., Steinberg, B.M., Bizekis, C., Greenberg, J., O’Connor, W.J., Javitt, N.B., Grossi, E.A.   +7 more
core   +1 more source

Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration

Journal of Lipid Research, 2003
Although the pool of cholesterol in the adult central nervous system (CNS) is large and of constant size, little is known of the process(es) involved in regulation of sterol turnover in this pool. In 7-week-old mice, net excretion of cholesterol from the
Chonglun Xie, Erik G. Lund, Stephen D. Turley, David W. Russell, John M. Dietschy   +4 more
doaj   +1 more source

Osteomalacia Following Iron Infusion Therapy in a Patient With Rendu‐Osler‐Weber Syndrome: F‐18‐FDG PET/CT Discrimination of a Stress Fracture in the Setting of a Musculoskeletal Tumor Mimic

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT This case report highlights a rare occurrence of osteomalacia induced by hypophosphatemia secondary to ferric carboxymaltose (FCM) therapy in a patient with hereditary hemorrhagic telangiectasia (HHT, or Rendu‐Osler‐Weber syndrome). A 21‐year‐old man presented with left tibial pain without prior trauma, accompanied by severe hypophosphatemia ...
Ioannis S. Vasios, Pipitsa N. Valsamaki, Konstantinos Tilkeridis, Savvas Deftereos, Efthymios Iliopoulos   +4 more
wiley   +1 more source

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Journal of Lipid Research, 2007
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li, Wenling Chen, John Y.L. Chiang   +2 more
doaj   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Plant sterol metabolism with emphasis on glycoalkaloid biosynthesis in potato [PDF]

, 2007
Glycoalkaloids are secondary metabolites present within species of the family Solanaceae. They are toxic to humans and animals, and it is important to keep the levels in potato (Solanum tuberosum L.) tubers below the safe limit for consumption ...
Arnqvist, Lisa
core  

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes

, 1995
In previous work we have demonstrated suppression of cholesterol 7α-hydroxylase by bile acids at the level of mRNA and transcription, resulting in a similar decline in bile acid synthesis in cultured rat hepatocytes.
Twisk, J., Wit, E.C.M. de, Princen, H.M.G.   +2 more
core  

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

BioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi, Margherita Turrini, Francesco Cei, Marta Menicatti, Gianluca Bartolucci, Amedeo Amedei   +5 more
wiley   +1 more source