Results 1 to 10 of about 14,312 (191)

Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy [PDF]

Frontiers in Oncology, 2023
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
doaj   +4 more sources

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor [PDF]

Nature Communications, 2020
Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters.
Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, Koji Nishi, Catherine C. Y. Chang, Ta-Yuan Chang, Tuoping Luo, Lei Chen   +9 more
doaj   +5 more sources

Comprehensive Analysis of Sterol O-Acyltransferase 1 as a Prognostic Biomarker and Its Association With Immune Infiltration in Glioma [PDF]

Frontiers in Oncology, 2022
Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) is an essential target for metabolic therapy. However, the prognostic value of SOAT1 and its association with immune infiltration has not been fully elucidated. Using
Xuyang Guo, Xuyang Guo, Shaolong Zhou, Shaolong Zhou, Zhuo Yang, Zhuo Yang, Zi-An Li, Zi-An Li, Weihua Hu, Lirui Dai, Lirui Dai, Wulong Liang, Xinjun Wang, Xinjun Wang   +13 more
doaj   +4 more sources

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids [PDF]

Communications Biology
Viruses depend on host metabolic pathways and flaviviruses are specifically linked to lipid metabolism. During dengue virus infection lipid droplets are degraded to fuel replication and Zika virus (ZIKV) infection depends on triglyceride biosynthesis ...
Anja Schöbel, Vinicius Pinho dos Reis, Rabea Burkhard, Julia Hehner, Laura Schneider, Martin Schauflinger, Gabrielle Vieyres, Eva Herker   +7 more
doaj   +4 more sources

Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome. [PDF]

Kidney Int, 2020
Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome.
Liu X, Ducasa GM, Mallela SK, Kim JJ, Molina J, Mitrofanova A, Wilbon SS, Ge M, Fontanella A, Pedigo C, Santos JV, Nelson RG, Drexler Y, Contreras G, Al-Ali H, Merscher S, Fornoni A.   +16 more
europepmc   +4 more sources

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S] [PDF]

Journal of Lipid Research, 2014
Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance.
Camilla Pramfalk, Tiffany A. Melhuish, David Wotton, Zhao-Yan Jiang, Mats Eriksson, Paolo Parini   +5 more
doaj   +3 more sources

Sevoflurane attenuates proliferative and migratory activity of lung cancer cells via mediating the microRNA-100-3p/sterol O-Acyltransferase 1 axis

Chinese Journal of Physiology, 2023
Recently, evidence has shown that microRNA-100-3p (miR-100-3p) has been revealed as a tumor suppressor in diverse human diseases, while its capability in lung cancer warrants further validation. In this work, we aimed to discuss the impact of sevoflurane
Bicheng Fu, Fucheng Zhou, Jian Zhang, Xianglong Kong, Boxiong Ni, Jianlong Bu, Shidong Xu, Changjun He   +7 more
doaj   +3 more sources

Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice. [PDF]

Exp Mol Pathol, 2015
The cholesterol-metabolizing enzyme sterol O-acetyltransferase (SOAT1) is implicated in an increasing number of biological and pathological processes in a number of organ systems, including the differentiation of the hair shaft. While the functional and regulatory mechanisms underlying these diverse functional roles remain poorly understood, the ...
Potter CS, Kern MJ, Baybo MA, Pruett ND, Godwin AR, Sundberg JP, Awgulewitsch A.   +6 more
europepmc   +5 more sources

Sterol O-Acyltransferase 1 (<i>SOAT1</i>): A Genetic Modifier of Niemann-Pick Disease, Type C1. [PDF]

Int J Mol Sci
Niemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting a significant effect of modifier genes.
Farhat NY, Alexander D, McKee K, Iben J, Rodriguez-Gil JL, Wassif CA, Cawley NX, Balch WE, Porter FD.   +8 more
europepmc   +3 more sources

Comprehensive prognostic and immune analysis of sterol O-acyltransferase 1 in patients with hepatocellular carcinoma. [PDF]

World J Hepatol
BACKGROUND Sterol O-acyltransferase 1 (SOAT1) is an important target in the diagnosis and treatment of liver cancer. However, the prognostic value of SOAT1 in patients with hepatocellular carcinoma (HCC) is still not clear. AIM To investigate the correlation of SOAT1 expression with HCC, using RNA-seq and gene expression ...
Gan CJ, Zheng Y, Yang B, Cao LM.
europepmc   +3 more sources