Results 91 to 100 of about 14,312 (191)

Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion

Breast Cancer Research
Signaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results in enhanced proliferation, migration, and invasion of tumor cells.
Jennifer E. Tuokkola, Lyndsay E. Reese, Ying Wang, Christine H. O’Connor, Jillian G. VanTreeck, Annisa H. Rumahorbo, Kathryn L. Schwertfeger   +6 more
doaj   +1 more source

An Exploratory Study on the Pathogenic Role of Faecal Extracellular Vesicles in Metabolic Dysfunction‐Associated Steatotic Liver Disease Progression and in Drug‐Induced Liver Injury

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
Fecal extracellular vesicles (fEVs) from DILI patients have a distinct bacterial profile. This study provides evidence that bacterial EVs enter the bloodstream. DILI and MASLD F≥3 fEVs increase the pro‐inflammatory response and hepatocyte steatosis. FEVs from DILI patients enhance the hepatotoxic potential of diclofenac.
Antonio J. Ruiz‐Malagón, Marina Herraiz‐Vilela, Jose Pinazo‐Bandera, Juan Pedro Toro‐Ortiz, Carlos López‐Gómez, Ailec Ho‐Plagaro, Lourdes Garrido‐Sánchez, Mercedes Robles‐Díaz, Bernard Taminiau, Georges Daube, Judith Sanabria‐Cabrera, Gonzalo Matilla‐Cabello, Maria Isabel Lucena, Raúl J. Andrade, Eduardo García‐Fuentes, Miren García‐Cortes, Cristina Rodriguez‐Diaz   +16 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

Lipids in Health and Disease, 2010
Background Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer.
Su-Myat Khine K, Khan Mohamed A, Ritchie Shawn A, Jayasinghe Dushmanthi, Ma Hong, Ahiahonu Pearson WK, Mankidy Rishikesh, Wood Paul L, Goodenowe Dayan B   +8 more
doaj   +1 more source

Lipotoxicity in the liver [PDF]

, 2013
Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21st century.
Bánhegyi, Gábor, Csala, Miklós, Kereszturi, Éva, Simon-Szabó, Laura, Szelényi, Péter, Zámbó, Veronika   +5 more
core   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds

Nature Communications
The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex ...
Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen   +20 more
doaj   +1 more source

TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway

Annals of Medicine
Background tRNA-derived small RNAs (tsRNAs), newly developed non-coding RNAs with specialized biological features, are aberrantly expressed in the majority of malignancies.
Qianyi Qi, Bairong Chen, Jinran Wu, Jing Xu, Hongyi Bao, Kangfeng Jin, Lin Chen, Guang Zhu, Feng Wang   +8 more
doaj   +1 more source

Effect of supplementation with different fat sources on the mechanisms involved in reproductive performance in lactating dairy cattle [PDF]

, 2012
peer reviewedSupplementary fat positively influences reproductive performance in dairy cattle, although the mechanisms involved are not clearly defined. Our objective was to determine the effects of four different fat supplements on follicle development,
Butler, Stephen, Dewhurst, Richard J., Evans, A.C.O., Hennessy, Alan A., Hutchinson, Ian A., Lonergan, P., Waters, Sinead M.   +6 more
core   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source