Results 101 to 110 of about 14,312 (191)

Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice

JCI Insight, 2022
Colorectal cancer (CRC) severely threatens human health and life span. An effective therapeutic strategy has not been established because we do not clearly know its pathogenesis.
Yahui Zhu, Li Gu, Xi Lin, Jinmiao Zhang, Yi Tang, Xinyi Zhou, Bingjun Lu, Xingrong Lin, Cheng Liu, Edward V. Prochownik, Youjun Li   +10 more
doaj   +1 more source

Regulation of Lipid Dysmetabolism and Neuroinflammation Progression Linked With Alzheimer's Disease Through Modulation of Dgat2

Aging Cell, Volume 25, Issue 3, March 2026.
Drosophila and mouse models of Alzheimer's disease exhibit lipid accumulation and neuroinflammation, leading to progressive impairments in memory, locomotion, sleep, circadian rhythms, and synaptic integrity. Knockdown of Dgat2 reduces lipid accumulation and neuroinflammatory signaling, rescuing these deficits and highlighting a conserved, crossspecies
Archana Yadav, Xiaosen Ouyang, Morgan Barkley, John C. Watson, Kishore Madamanchi, Josh Kramer, Jianhua Zhang, Girish C. Melkani   +7 more
wiley   +1 more source

Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species [PDF]

, 2016
Genes mapped on Fig. 3.
Akihito Yasuoka, Asuka Kamei, Fumika Shinozaki, Kaori Kondo, Keiko Abe, Kosuke Shimada, Kota Kumagai, Soichi Arai, Takashi Abe, Takashi Kondo, Yuki Watanabe   +10 more
core   +4 more sources

Synthetic Biology and Metabolic Engineering of Microalgae for Sustainable Lipid and Terpenoid Production: An Updated Perspective

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1359-1376, March 2026.
ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka, Yu Wang, Sally Do, Julia Yuson, Samir Kumar Khanal, Krzysztof Zienkiewicz, Zhi‐Yan Du   +6 more
wiley   +1 more source

Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function [PDF]

, 2017
It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signalling platforms called lipid rafts, essential for T-cell activation and function.
Adlanmerini, Aktas, al Yacoub, Araldi, Ashdown, Balamuth, Bensinger, Bovenga, Brown, Burridge, Chaudhri, Cho, Clark, Daniel, Degroote, Della Torre, Dimeloe, Dunn, Fievet, Foryst-Ludwig, Fox, Gaudet, Gervois, Greenwood, Griffié, Guo, Harris, Herold, Horton, Hughes, Ifergan, Iida, Ikonen, Ishikawa, Ito, Janes, Jeong, Jones, Jury, Jury, Jury, Kanakasabai, Keller, Kidani, Kidani, Kidani, Kirchgessner, Kishimoto, Klein, Kosters, Köberlin, Lappano, Lee, Levental, Levental, Levin, Lingwood, Lisse, Lovett-Racke, Lund, Luquet, Magee, McDonald, Megha, Mesmin, Miguel, Molnár, Nagafuku, Nazarov-Stoica, Ngo, Nuñez, Oliver, Owen, Owen, Pelekanou, Phiel, Quinet, Radhakrishnan, Repa, Rong, Rubin-Delanchy, Sankaran-Walters, Simigdala, Simons, Spann, Steffensen, Sun, Svenson, Swamy, Swinnen, Tang, Tcherepanova, Thangavel, Uppal, Uppal, Varga, Waddington, Waddington, Walcher, Wang, Wang, Wang, Wang, Wang, Wu, Yang, Youssef, Zalba, Zelcer, Zhu   +109 more
core   +2 more sources

Plant Lipid Droplets and Derived Lipidic Nano‐Assemblies: Structure, Biogenesis and Pharmaceutical Applications

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1322-1343, March 2026.
ABSTRACT Lipid droplets (LDs) serve as the primary storage site for neutral lipids in plant cells, with growing evidence supporting many additional biological roles, such as in lipid homeostasis, signalling, trafficking, inflammatory responses and inter‐organelle communication.
Abdulsamie Hanano, Amal Yousfan, Denis J. Murphy   +2 more
wiley   +1 more source

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]

, 2015
Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying, Liu, Hui-Xin, Wan, Yu-Jui Yvonne   +2 more
core   +2 more sources

Molecular insights into volatile organic compound sensing and signaling in plants

The Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Plants interact with their surrounding environment through the perception of a vast and structurally diverse array of volatile organic compounds (VOCs); however, the molecular mechanisms involved remain mostly unknown. Despite the large number of VOCs emitted and perceived by plants, only a small number of phylogenetically distinct, but often ...
Matthew E. Bergman, Sun Hyun Chang, Benoît Boachon, Nitzan Shabek, Natalia Dudareva   +4 more
wiley   +1 more source

Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice*s⃞

Journal of Lipid Research, 2009
To evaluate the effect of genetic background on high-density lipoprotein cholesterol (HDL) levels in Soat1−/− mice, we backcrossed sterol O-acyltransferase 1 (Soat1)−/− mice, originally reported to have elevated HDL levels, to C57BL/6 mice and ...
Zhiguang Su, Xiaosong Wang, Shirng-Wern Tsaih, Aihong Zhang, Allison Cox, Susan Sheehan, Beverly Paigen   +6 more
doaj   +1 more source

Yeast Gup1(2) proteins are homologues of the Hedgehog Morphogens Acyltransferases HHAT(L): facts and implications [PDF]

, 2016
In multiple tissues, the Hedgehog secreted morphogen activates in the receiving cells a pathway involved in cell fate, proliferation and differentiation in the receiving cells. This pathway is particularly important during embryogenesis. The protein HHAT
Amanai, Chang, Chong, Kumar, Lorenz, Micchelli, Palková, Palková, Roelants, Verduyckt, Zhang, Zhang, Zhang, Zupan   +13 more
core   +2 more sources