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The Role of Sterol O-acyltransferase 1 In Obesity And In Prostate Cancer
2023ABSTRACT The worldwide obesity prevalence has almost tripled since 1973 according to the World Health Organization. In the United States, the disease is especially prevalent, with a recorded prevalence of 41.9 percent in 2017, as reported by the National Health and Nutrition Examination Survey.
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Biochemical and Biophysical Research Communications, 2018
Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester. In the present study, wild-type (WT) mice and SOAT1-knockout (KO) mice with a C57BL6 background fed a HFD were used to explore the role of SOAT1 in the hypothalamus.
Ning, Xu +6 more
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Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester. In the present study, wild-type (WT) mice and SOAT1-knockout (KO) mice with a C57BL6 background fed a HFD were used to explore the role of SOAT1 in the hypothalamus.
Ning, Xu +6 more
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The FASEB Journal, 2017
During avian embryonic development, absorptions of nutrients is mainly responsible by endodermal epithelial cells (EECs) in the yolk sac membrane (YSM). Yolk lipids are actively absorbed in late stages of incubation. Sterol O‐acyltransferase (SOAT), regulating the cholesterol esterification with long‐chain fatty acid, is the key for lipid utilization ...
Han‐Jen Lin +4 more
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During avian embryonic development, absorptions of nutrients is mainly responsible by endodermal epithelial cells (EECs) in the yolk sac membrane (YSM). Yolk lipids are actively absorbed in late stages of incubation. Sterol O‐acyltransferase (SOAT), regulating the cholesterol esterification with long‐chain fatty acid, is the key for lipid utilization ...
Han‐Jen Lin +4 more
openaire +1 more source
Insect Sterol Nutrition: Physiological Mechanisms, Ecology, and Applications
Annual Review of Entomology, 2020Xiangfeng Jing, Spencer T Behmer
exaly
Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins
Cell, 2019Maria Szomek +2 more
exaly
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
Cell, 1994Xiaodong Wang +2 more
exaly
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Nature Reviews Molecular Cell Biology, 2012Anna C Calkin, Peter Tontonoz
exaly
Yeast metabolic engineering – Targeting sterol metabolism and terpenoid formation
Progress in Lipid Research, 2013Tamara Wriessnegger, Harald Pichler
exaly