Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation [PDF]
Lipids in Health and Disease, 2012 Background Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are largely unknown.
Schmidt Simone +6 more
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Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal [PDF]
Mol Endocrinol, 2011 Abstract Context: Steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) is a master regulator of adrenal development and steroidogenesis. Defects in several known targets of SF-1 can cause adrenal disorders in humans.
Ferraz-de-Souza B +6 more
europepmc +7 more sources
p53-SOAT1 Axis: A Novel Target for Tumor Lipid Metabolism and Therapy [PDF]
Chinese Journal of Lung CancerCancer treatment is a significant challenge facing global medicine, with complex molecular mechanisms and drug resistance being key factors limiting treatment outcomes.
Xi YU +5 more
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SOAT1 in ovarian cancer cells regulates immune response mediated by CD8+ T cells [PDF]
Journal of Ovarian ResearchBackground Sterol-O acyltransferase 1 (SOAT1) functions by converting cholesterol and acyl-CoA into cholesterol ester and CoA-SH. SOAT1 inhibition suppresses tumor growth.
Jiangnan He +8 more
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Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. [PDF]
J Invest Dermatol, 2010 Wu B +9 more
europepmc +4 more sources
N4-acetylcytidine-mediated SOAT1 upregulation aggravates heart failure by inducing NCOA4-dependent ferroautophagy and ferroptosis in cardiomyocytes [PDF]
Cellular and Molecular Life SciencesHeart failure (HF) remains a critical global health challenge, with accumulating evidence implicating iron metabolism dysregulation through ferritinophagy activation in disease progression.
Jizhao Deng, Xiting Nong, Guang Yang
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Screening and functional validation of lipid metabolism-related lncRNA-46546 based on the transcriptome analysis of early embryonic muscle tissue in chicken [PDF]
Animal Bioscience, 2023 Objective The study was conducted to screen differentially expressed long noncoding RNA (lncRNA) in chickens by high-throughput sequencing and explore its mechanism of action on intramuscular fat deposition.
Ruonan Chen +5 more
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Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions. [PDF]
Liver IntABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Lian J, Lareu RR, Patil M, Falasca M.
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Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage
Biomedicines, 2022 Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options, novel therapies are desperately needed. Recent studies have shown that GBM acquires large amounts of lipids for rapid growth through activation of sterol ...
Yongjun Kou, Feng Geng, Deliang Guo
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Cholesterol esterification and p53-mediated tumor suppression
Exploration of Targeted Anti-tumor Therapy, 2023 Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53’s product, p53 regulates many biological processes, including cell metabolism. Cholesterol is a key lipid needed for the maintenance of
Youjun Li +2 more
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