Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p [PDF]
, 2010 Background GUP1 gene was primarily identified in Saccharomyces cerevisiae being connected with glycerol uptake defects in association with osmotic stress response.
Célia Ferreira +5 more
core +2 more sources
Blocking cholesterol storage to treat Alzheimer’s disease
Exploration of Neuroprotective Therapy, 2021 Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions.
Ta Yuan Chang +6 more
doaj +1 more source
Mutations in UDP-Glucose:Sterol Glucosyltransferase in Arabidopsis Cause Transparent Testa Phenotype and Suberization Defect in Seeds [PDF]
, 2009 In higher plants, the most abundant sterol derivatives are steryl glycosides (SGs) and acyl SGs. Arabidopsis (Arabidopsis thaliana) contains two genes, UGT80A2 and UGT80B1, that encode UDP-Glc:sterol glycosyltransferases, enzymes that catalyze the ...
Auer, Manfred +14 more
core +5 more sources
Sterol-O acyltransferase 1 is inhibited by gga-miR-181a-5p and gga-miR-429-3p through the TGFβ pathway in endodermal epithelial cells of Japanese quail [PDF]
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2019 AbstractNutrients are utilized and re-constructed by endodermal epithelial cells (EECs) in yolk sac membranes in avian species. Sterol-O acyltransferase 1 (SOAT1) is the key enzyme to convert cholesterol to cholesteryl ester for delivery to growing embryos.
Lin, Han-Jen +3 more
openaire +2 more sources
Biosynthesis of α-Tocopherol and Plastoquinone-9 in spinach chloroplasts [PDF]
, 1980 Prenylation and methylation reaction in al biosynthesis is localized in the envelope membranes of the chloroplasts, while PQ-9 biosynthesis takes place in the envelope membranes and also in the thylakoid membranes.
Mazliak, P. +2 more
core +1 more source
Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]
, 2018 Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia +2 more
core +1 more source
Brain cholesterol in normal and pathological aging [PDF]
, 2011 Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Lütjohann, D. (Dieter) +2 more
core +5 more sources
Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]
, 2020 Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian +14 more
core +2 more sources
Cholesterol homeostasis: a key to prevent or slow down neurodegeneration [PDF]
, 2013 Neurodegeneration, a common feature for many brain disorders, has severe consequences on the mental and physical health of an individual. Typically human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people ...
Anchisi L., Dessi S., Mandas A, Pani A.
core +1 more source
Involvement of fatty acid synthase in dengue virus infection [PDF]
, 2017 BACKGROUND: The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular lipids play important roles at ...
Duncan R. Smith +10 more
core +1 more source