Results 51 to 60 of about 14,312 (191)

Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion [PDF]

, 2018
Bio-based production of fatty acids and fatty acid-derived products can enable sustainable substitution of petroleum-derived fuels and chemicals. However, developing new microbial cell factories for producing high levels of fatty acids requires extensive
Ferreira, Raphael, Nielsen, Jens, Siewers, Verena, Teixeiraa, Paulo Goncalves   +3 more
core   +1 more source

DNA methyltransferase 1 deficiency improves macrophage motility and wound healing by ameliorating cholesterol accumulation

npj Regenerative Medicine, 2023
Healing of the cutaneous wound requires macrophage recruitment at the sites of injury, where chemotactic migration of macrophages toward the wound is regulated by local inflammation. Recent studies suggest a positive contribution of DNA methyltransferase
Chuanrong Zhao, Qianru Yang, Runze Tang, Wang Li, Jin Wang, Fangfang Yang, Jianan Zhao, Juanjuan Zhu, Wei Pang, Ning Li, Xu Zhang, Xiao Yu Tian, Weijuan Yao, Jing Zhou   +13 more
doaj   +1 more source

The metabolic adaptation of bile acids and cholesterol after biliary atresia in lamprey via transcriptome-based analysis

Heliyon, 2023
Lamprey underwent biliary atresia (BA) at its metamorphosis stage. In contrast to patients with BA who develop progressive disease, lamprey can grow and develop normally, suggesting that lamprey has several adaptations for BA.
Qipeng Zhang, Jilong Pan, Yingying Zhu, Jindi Liu, Yue Pang, Jiarui Li, Pengju Han, Meng Gou, Jun Li, Peng Su, Qingwei Li, Yan Chi   +11 more
doaj   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization

npj Metabolic Health and Disease
Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and ...
Syed A. H. Zaidi, Ruth B. Caldwell, Modesto A. Rojas   +2 more
doaj   +1 more source

Exogenous H2S promotes ubiquitin‐mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S‐sulfhydration

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Diabetic cardiomyopathy, a distinctive complication of diabetes mellitus, has been correlated with the presence of intracellular lipid deposits.
Shiwu Zhang, Mengyi Wang, Hongxia Li, Qianzhu Li, Ning Liu, Shiyun Dong, Yajun Zhao, Kemiao Pang, Jiayi Huang, Cheng Ren, Yan Wang, Zhen Tian, Fanghao Lu, Weihua Zhang   +13 more
doaj   +1 more source

miRNAs regulate the expression of sterol‐O acyltransferase 1 through inhibiting the 3′UTR of TGFβ receptor type 1 during embryonic development

The FASEB Journal, 2019
Nutrients are utilized and re‐constructed by endodermal epithelial cells (EECs) of yolk sac membrane (YSM) in avian species during embryonic development. Sterol‐O acyltransferase 1 (SOAT1) is the key enzyme to convert cholesterol to cholesteryl ester, and for packaging into very‐low‐density lipoproteins for further delivering to growing embryos. During
HAN‐JEN LIN, SHIH‐TORNG DING
openaire   +1 more source

High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment

Advanced Science, EarlyView.
High‐content Stimulated Raman Scattering (SRS) Imaging reveals that ovarian cancer cells surviving Chimeric Antigen Receptor (CAR) ‐T cell challenge exhibit increased cholesterol esterification. Pharmacological inhibition of this pathway with Avasimibe significantly enhances CAR‐T induced killing of ovarian cancer cells by reducing cancer cell ...
Chinmayee V. Prabhu Dessai, Zhuoying Huang, Haonan Lin, Guangrui Ding, Hongjian He, Menna Siddiqui, Meng Zhang, Wilson Wong, Ji‐Xin Cheng   +8 more
wiley   +1 more source

Sulforaphane Protects against Unilateral Ureteral Obstruction-Induced Renal Damage in Rats by Alleviating Mitochondrial and Lipid Metabolism Impairment

Antioxidants, 2022
Unilateral ureteral obstruction (UUO) is an animal rodent model that allows the study of obstructive nephropathy in an accelerated manner. During UUO, tubular damage is induced, and alterations such as oxidative stress, inflammation, lipid metabolism ...
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sánchez-Lozada, Fernando Enrique García-Arroyo, Isabel Amador-Martínez, Marisol Orozco-Ibarra, Francisca Fernández-Valverde, José Pedraza-Chaverri   +9 more
doaj   +1 more source

Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology

Barrier Immunity, EarlyView.
Tissue‐resident memory T (TRM) cells in barrier tissues provide a frontline defense against invading pathogens. Immune (Signals 1–3) and nutrient (Signal 4) cues play an integral role in directing TRM formation and heterogeneity. The spatial and temporal organization of these signals establishes durable TRM cells across tissues, enabling diverse ...
Jana L. Raynor, Hongbo Chi
wiley   +1 more source