Results 71 to 80 of about 61,990 (306)

POTENTIAL HEALTHCARE SAVINGS FROM PLANT STEROL ENRICHED FOODS IN CANADA [PDF]

Increased consumption of foods containing plant sterols has the potential to reduce the incidence of coronary heart disease (CHD) and thus reduce costs associated with treating that disease in a significant way.
Gyles, Collin, Jones, Peter J.H., Carlberg, Jared G.   +2 more
core  

Metabolism of dietary Δ8-sterols and 9β, 19-cyclopropyl sterols by Locusta migratoria

, 1989
International audienceAdult female locusts were reared on wheat seedlings (experimental wheat) containing more than 97% of 9,10-cyclopropyl sterols and Δ8-sterols and less than 2% of Δ5-sterols.
Benveniste, Pierre, Hoffmann, Jules A., Charlet, Maurice, Corio-Costet, Marie-France   +3 more
core   +1 more source

Phylogenetic distribution of fungal sterols. [PDF]

, 2010
BACKGROUND: Ergosterol has been considered the "fungal sterol" for almost 125 years; however, additional sterol data superimposed on a recent molecular phylogeny of kingdom Fungi reveals a different and more complex situation.
Weete John D., John D Weete, Blackwell Meredith, Abril Maritza, Meredith Blackwell, Maritza Abril   +5 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Pathway of cholesterol biosynthesis in the brain of the neonatal rat

Journal of Lipid Research, 1966
Suckling rats were killed at various intervals after intraperitoneal injection of acetate-1-14C and their brain sterols were analyzed by column, thin-layer, paper, and gas-liquid chromatography.
Thomas J. Holstein, William A. Fish, William M. Stokes   +2 more
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Effect of Oxylipins, Terpenoid Precursors and Wounding on Soft Corals’ Secondary Metabolism as Analyzed via UPLC/MS and Chemometrics

Molecules, 2017
The effect of three oxylipin analogues, a terpenoid intermediate and wounding on the secondary metabolism of the soft corals Sarcophyton glaucum and Lobophyton pauciflorum was assessed. Examined oxylipins included prostaglandin (PG-E1), methyl jasmonate (
Mohamed A. Farag, Hildegard Westphal, Tarek F. Eissa, Ludger A. Wessjohann, Achim Meyer   +4 more
doaj   +1 more source

Comprehensive Overview of the Brassinosteroid Biosynthesis Pathways: Substrates, Products, Inhibitors, and Connections

Frontiers in Plant Science, 2020
Brassinosteroids (BRs) as a class of steroid plant hormones participate in the regulation of numerous developmental processes, including root and shoot growth, vascular differentiation, fertility, flowering, and seed germination, as well as in responding
Andrzej Bajguz, Magdalena Chmur, Damian Gruszka   +2 more
doaj   +1 more source

The mysterious route of sterols in oomycetes.

, 2021
Sterols are a class of lipids with essential roles in sustaining the domain structure of cell membranes and regulating biological processes [1]. Human health is affected by high cholesterol levels [2]; drugs preventing this are widely used. Also striking
Wang, Weizhen, Govers, Francine, Weizhen Wang, Francine Govers, Liu, Xili, Xili Liu   +5 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source