Results 11 to 20 of about 338 (123)

Long-lasting effects of chronic exposure to chemical pollution on the hologenome of the Manila clam [PDF]

Evolutionary Applications, Volume 14, Issue 12, Page 2864-2880, December 2021., 2021
Chronic exposure to pollutants affects natural populations, creating specific molecular and biochemical signatures. In the present study, we tested the hypothesis that chronic exposure to pollutants might have substantial effects on the Manila clam ...
Babbucci, M., Bargelloni, L., Benedetti, M., Boffo, L., Cardazzo, B., Carraro, L., Carrer, C., Centelleghe, C., Ciofi, C., Dalla Rovere, G., Fattorini, D., Ferraresso, S., Ghiselli, F., Gorbi, S., Iannello, M., Mazzariol, S., Mezzelani, M., Milan, M., Nardi, A., Patarnello, T., Pittura, L., Regoli, F., Smits, M., Varagnolo, M.   +23 more
core   +2 more sources

Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. [PDF]

Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016
Traditional Chinese medicine (TCM) still needs more scientific rationale to be proven for it to be accepted further in the West. We are now in the position to propose computational hypotheses for the mode-of-actions (MOAs) of 45 TCM therapeutic action ...
Bender, Andreas, Drakakis, Georgios, Fan, Tai-Ping, Fu, Xianjun, Liggi, Sonia, Mohamad Zobir, Siti Zuraidah, Mohd Fauzi, Fazlin   +6 more
core   +7 more sources

Network Pharmacology Analyses of the Pharmacological Targets and Therapeutic Mechanisms of Salvianolic Acid A in Myocardial Infarction

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Objective. Salvianolic acid A, a natural polyphenolic ingredient extracted from traditional Chinese medicine, possesses an excellent pharmacological activity against cardiovascular diseases. Herein, therapeutic mechanisms of salvianolic acid A in myocardial infarction were explored through systematic and comprehensive network pharmacology analyses ...
Qing Huang, Chao Zhang, Shaoyong Tang, Xiaoyan Wu, Xiong Peng, Qing Li   +5 more
wiley   +1 more source

Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology

Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020
Oroxylum indicum (O. indicum) is an important traditional Chinese medicine that exerts a wide spectrum of pharmacological activities. However, the pharmacological effect of O. indicum and its mechanism of action have not to be systematically elucidated yet. In this study, the druggability for active compounds of O.
Junmin Chen, Jianyong Chen, Jingrong Lu, Orazio Taglialatela-Scafati   +3 more
wiley   +1 more source

Proteomic analysis reveals semaglutide impacts lipogenic protein expression in epididymal adipose tissue of obese mice [PDF]

, 2023
Background and objectivesObesity is a global health problem with few pharmacologic options. Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that induces weight loss. Yet, the role of semaglutide in adipose tissue has not yet been examined.
Ruiyi Zhu, Ruiyi Zhu, Shuchun Chen, Shuchun Chen   +3 more
core   +1 more source

Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling [PDF]

, 2012
Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present
Cupitt, John, Edwards, Robert J., Fritsche, Ellen, Gierula, Magdalena, Götz, Christine, Rodrigues-Lima, Fernando, van Eijl, Sven, Zhu, Zheying   +7 more
core   +5 more sources

Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the United States [PDF]

, 2013
Purpose Circulating estrogen levels are relevant in glaucoma phenotypic traits. We assessed the association between an estrogen metabolism single nucleotide polymorphism (SNP) panel in relation to primary open angle glaucoma (POAG), accounting for gender.
Allingham, R. Rand, Bailey, Jessica Cooke, Brilliant, Murray, Budenz, Donald L., Christen, William G., Fingert, John, Friedman, David S., Gaasterland, Douglas, Gaasterland, Terry, Haines, Jonathan L., Hauser, Michael A., Kang, Jae H., Kraft, Peter, Lee, Richard K., Lichter, Paul R., Liu, Yutao, Loomis, Stephanie J., McCarty, Catherine A., Moroi, Sayoko E., Olson, Lana, Pasquale, Louis R., Pericak-Vance, Margaret A., Realini, Tony, Richards, Julia E., Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Vollrath, Douglas, Weinreb, Robert N., Wiggs, Janey L., Wollstein, Gadi, Yaspan, Brian L., Zack, Donald J., Zhang, Kang   +34 more
core   +3 more sources

The transcriptome of metamorphosing flatfish [PDF]

, 2016
Background Flatfish metamorphosis denotes the extraordinary transformation of a symmetric pelagic larva into an asymmetric benthic juvenile. Metamorphosis in vertebrates is driven by thyroid hormones (THs), but how they orchestrate the cellular ...
Alves, Ricardo N., Clark, M.S., Gomes, Ana S., Power, Deborah M., Reinhard, Richard, Rønnestad, Ivar, Smáradóttir, H., Stueber, Kurt, Thorne, M.A.S., Tine, Mbaye   +9 more
core   +11 more sources

Molecular mechanisms related to hormone inhibition resistance in prostate cancer [PDF]

, 2019
Management of metastatic or advanced prostate cancer has acquired several therapeutic approaches that have drastically changed the course of the disease.
Cheng L., Cimadamore A., Di Nunno V., Lopez-Beltran A., Massari F., Mollica V., Montironi R., Santoni M., Scarpelli M.   +8 more
core   +1 more source

Congenital Ichthyoses: 11 Cases from the Pediatric Dermatology Multidisciplinary Consultation of the Centro Hospitalar e Universitário de Lisboa Central [PDF]

, 2019
Introdução: As ictioses são um grupo heterogéneo de distúrbios genéticos hereditários que ocorrem devido a um defeito da queratinização e consequente disrupção da função de barreira cutânea.
Borges, Ana Sofia, Brasileiro, Ana, Cordeiro, A., Paiva Lopes, Maria João   +3 more
core   +2 more sources