TOWARDS UNDERSTANDING MODE-OF-ACTION OF TRADITIONAL MEDICINES BY USING IN SILICO TARGET PREDICTION [PDF]
, 2018 Traditional medicines (TM) have been used for centuries to treat illnesses, but in many cases their modes-of-action (MOAs) remain unclear. Given the increasing data of chemical ingredients of traditional medicines and the availability of large-scale ...
BINTI MOHAMAD ZOBIR, SITI ZURAIDAH
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Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions [PDF]
, 2012 The biological mechanisms underlying castration resistance of prostate cancer are not fully understood. In the present study, we examined the role of organic anion transporting polypeptides (OATPs) as importers of dehydroepiandrosterone sulfate (DHEAS ...
Arakawa Hiroshi +7 more
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Stem Cells International, Volume 2019, Issue 1, 2019., 2019 Adipose‐derived mesenchymal stem cells (MSC‐ATs) are representative cell sources for cell therapy. However, how cell stress resulting from passage influences the MSC‐AT protein expression has been unclear. In this study, a protein expression analysis was performed by liquid chromatography with tandem mass spectrometry (LC‐MS/MS) using mouse primary ...
Yoshiki Nakashima +9 more
wiley +1 more source
Unravelling the genetic and molecular mechanisms of the left-right patterning genes Pkd1l1 and Pkd2 [PDF]
, 2023 Pkd1 and Pkd2 encode the polycystin proteins which underlie human ADPKD, a major cause of end stage renal failure. Recently, by analysing the Pkd2lrm4 mouse, a previous member of the lab provided evidence that loss of ciliary PKD2 underlies kidney cyst ...
Dyer, Laura
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Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019 Lung cancer is the most common cause of cancer death with high morbidity and mortality, which non‐small‐cell lung cancer (NSCLC) accounting for the majority. Traditional Chinese Medicine (TCM) is effective in the treatment of complex diseases, especially cancer. However, TCM is still in the conceptual stage. The interaction between different components
Xing Su +10 more
wiley +1 more source
Estrone Sulfatase Inhibitors as New Anticancer Agents [PDF]
, 2019 Enzyme steroid sulfatase (STS) is considered as a promising therapeutic target for the treatment of hormone-dependent oncological diseases such as breast, endometrial, prostate cancers, and endometriosis.
Morozkina, Svetlana N. +1 more
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The schlafen core domain: from structure to function [PDF]
, 2018 The immune system is a complex network of processes and structures to protect the organism against infectious diseases. All processes, which include the maturation of individual immune cells, must be strictly regulated to prevent malfunction.
Huber, Elisabeth
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Producción científica institucional y posicionamiento nacional: el caso del Hospital General de México [PDF]
, 2004 The purpose of this work was to identify the scientific output, position and visibility of Mexico’s General Hospital (Hospital General de México-HGM).
Gutiérrez-Carrasco, A. +3 more
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The role of protein oxidation in ageing & disease [PDF]
Ageing is a natural phenomenon of the human lifecycle, yet it is still not understood what causes the deterioration of the human body near the end of the lifespan.
Pasha, Sabah
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Transmembrane protein topology prediction using support vector machines [PDF]
, 2009 Background Alpha-helical transmembrane (TM) proteins are involved in a wide range of important biological processes such as cell signaling, transport of membrane-impermeable molecules, cell-cell communication, cell recognition and cell adhesion. Many are
Timothy Nugent +55 more
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