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Syntheses of (−)-Tripterifordin and (−)-Neotripterifordin from Stevioside

The Journal of Organic Chemistry, 2018
We report short syntheses of (-)-tripterifordin and (-)-neotripterifordin, potent inhibitors of HIV replication, from stevioside, a natural sweetener used worldwide. The key transformations are reduction at C13 through the formation of a tertiary chloride and subsequent three-step lactonization including a selective iodination at C20 by the ...
Shoji Kobayashi   +5 more
openaire   +2 more sources

Effect of stevioside on growth and reproduction*

Human Reproduction, 1991
The effect on growth and reproduction in hamsters of stevioside, which is extracted from stevia leaves (Stevia rebaudiana Bertoni) and is currently used as a non-caloric sweetener, was investigated. Four groups of 20 one-month-old hamsters (10 males and 10 females) were daily force-fed with stevioside (0.0, 0.5, 1.0 and 2.5 g/kg body wt/day ...
V, Yodyingyuad, S, Bunyawong
openaire   +2 more sources

Stevioside and related compounds: Therapeutic benefits beyond sweetness

Pharmacology & Therapeutics, 2009
Stevioside, an abundant component of Stevia rebaudiana leaf, has become well-known for its intense sweetness (250-300 times sweeter than sucrose) and is used as a non-caloric sweetener in several countries. A number of studies have suggested that, beside sweetness, stevioside along with related compounds, which include rebaudioside A (second most ...
Varanuj, Chatsudthipong   +1 more
openaire   +2 more sources

Hydrolysis of the diterpenoid glycoside, stevioside

Phytochemistry, 1990
Abstract The minor products from the acid-catalysed hydrolysis of the diterpenoid glycoside, stevioside have been identified and the location of the deuterium has been established when the hydrolysis is carried out in the presence of deuterium bromide.
Anthony G. Avent   +2 more
openaire   +1 more source

Renal Excretion of Stevioside in Rats

Journal of Natural Products, 1992
The renal excretion of stevioside, a glycoside extracted from the leaves of Stevia rebaudiana, and its effect on renal excretion of several substances, was studied through clearance techniques in Wistar rats. After a control period, stevioside was infused iv at four concentrations (4, 8, 12, and 16 mg/kg).
openaire   +2 more sources

ChemInform Abstract: TOTAL SYNTHESIS OF STEVIOSIDE

Chemischer Informationsdienst, 1981
AbstractDie Überführung von Steviol (Ia), das bereits synthetisiert worden ist, in die Titelverbindung (VI) wird beschrieben: Glycosidierung des (Ia)‐Esters (Ib) mit dem Glucopyranosid (II) [→(IIIa)] und Glycosidierung des Verseifungsproduktes (IIIb) mit Acetobromglucose (IV) liefern die Verbindung (Va), die über die Stufen (Vb) und (Vc) in ...
T. OGAWA, M. NOZAKI, M. MATSUI
openaire   +1 more source

Photostability of Rebaudioside A and Stevioside in Beverages

Journal of Agricultural and Food Chemistry, 2008
The Coca-Cola Company and Cargill, Inc. have initiated the development and commercialization of the Stevia rebaudiana (Bertoni) derived sweetener rebaudioside A. Efforts were focused on high purity rebaudioside A (>97% by HPLC), commonly known as rebiana. In the course of the development program, extensive stability studies were carried out on rebiana,
John F, Clos   +2 more
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Downstream processing of stevioside and its potential applications

Biotechnology Advances, 2011
Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana Bertoni, which is commercially produced by conventional (chemical/physical) processes. This article gives an overview of the stevioside structure, various analysis technique, new technologies required and the advances achieved in recent years.
Munish, Puri   +2 more
openaire   +2 more sources

Pharmacokinetic studies of 131I-Stevioside and its metabolites

Nuclear Medicine and Biology, 1996
131I-STEVIOSIDE (1.10 MBq) was injected i.v in Wistar male rats, in distribution in the body and metabolism were studied. The highest concentration of radioactivity was observed in the liver and in the small intestine after 10 and 120 minutes, respectively. At 2 h after injection, the radioactivity eliminated in the bile was 52.0% of the original dose.
V N, Cardoso   +4 more
openaire   +2 more sources

Development of pure certified reference material of stevioside

Food Chemistry, 2018
Pure stevioside was extracted from leaves of Stevia rebaudiana (Bertoni) to be used as a reference material in the instrument calibration or method validation process. The mass fraction was determined by comparison between the mass balance method and quantitative nuclear magnetic resonance (qNMR) spectroscopy. The impurities in the sample were analyzed
Nongluck Tangpaisarnkul   +5 more
openaire   +2 more sources

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