Results 31 to 40 of about 25,993 (241)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Fracture asperity evolution during the transition from stick slip to stable sliding

Philosophical Transactions of the Royal Society A, 2021
Fracture asperities interlock or break during stick slip and ride over each other during stable sliding. The evolution of fracture asperities during the transition between stick slip and stable sliding has attracted less attention, but is important to ...
C. Mei, Wei Wu
semanticscholar   +1 more source

Low‐Angle Grain Boundaries and Re‐Segregation in Single‐Crystalline Ni‐Base Superalloys

Advanced Engineering Materials, EarlyView.
This work demonstrates that Re‐segregation at low‐angle grain boundaries (LAGBs) in Ni‐base superalloys is influenced by misorientation angle. Advanced microscopy and atom probe tomography reveal that higher misorientation angles increases Re‐segregation.
Alireza B. Parsa, Aparna Saksena, Alesander Kostka, Pascal Thome, Felicitas Scholz, Alexandre Mussi, Christoph Somsen, Baptiste Gault, Jan Frenzel, Gunther Eggeler   +9 more
wiley   +1 more source

Dataset on critical angular clamping speeds of fasteners

Data in Brief
This article reports on an experiment that studied the critical angular clamping speeds for fasteners using the Design of Experiments (DOE) methodology and Analysis of Variance (ANOVA). The study aimed to investigate the stick-slip phenomenon, a critical
Jeferson Ferreira, Adalto Farias, Fabrizio Leonardi, Ed C. Bordinassi, Roberto Bortolussi, Sergio Delijaicov   +5 more
doaj   +1 more source

Numerical Study on Characteristics of Stick-Slip Instability of Coal-Rock Parting-Coal Structure under Lateral Unloading [PDF]

Lithosphere
Unloading excavation can increase the possibility of rock burst, especially for coal seam with rock parting. In order to explore the evolution process of rock burst under lateral unloading, the combination of in situ measures and numerical experiments is
Heng Zhang, Guang-Jian Liu, Xian-Jun Ji, Wen-Hao Cao, Ya-Wei Zhu, Sher Bacha   +5 more
doaj   +1 more source

Stick‐Slip Tremor Beneath an Alpine Glacier

Geophysical Research Letters, 2021
Sliding of glacial ice over its base is typically described by a frictionless or slowly deforming bed. This view is challenged by recent seismic observations of stick‐slip motion at the ice‐bed interface.
J. Umlauft, F. Lindner, P. Roux, T. D. Mikesell, M. M. Haney, M. Korn, F. T. Walter   +6 more
doaj   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source

Phase Field Failure Modeling: Brittle‐Ductile Dual‐Phase Microstructures under Compressive Loading

Advanced Engineering Materials, EarlyView.
The approach by Amor and the approach by Miehe and Zhang for asymmetric damage behavior in the phase field method for fracture are compared regarding their fitness for microcrack‐based failure modeling. The comparison is performed for the case of a dual‐phase microstructure with a brittle and a ductile constituent.
Jakob Huber, Jan Torgersen, Ewald Werner
wiley   +1 more source

Numerical simulations of fault stick–slip characteristics in different temperature fields at laboratory scale

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
With the increasing demand for deep engineering development, there is an urgent need to study the evolution and formation mechanisms of the stick–slip process in faults at high temperatures.
Ke Ma, Yong Zhao, Qianbai Zhao, Haijun Xie, Jingrui Li   +4 more
doaj   +1 more source