Results 31 to 40 of about 242,267 (234)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Stick-slip singularity of the Giesekus fluid [PDF]

, 2015
The local asymptotic behaviour at the stick-slip singularity is determined for the Giesekus fluid in the presence of a solvent viscosity. In planar steady flow, the method of matched asymptotic expansions is used to show that it comprises a three region ...
Evans, Jonathan
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Dataset on critical angular clamping speeds of fasteners

Data in Brief
This article reports on an experiment that studied the critical angular clamping speeds for fasteners using the Design of Experiments (DOE) methodology and Analysis of Variance (ANOVA). The study aimed to investigate the stick-slip phenomenon, a critical
Jeferson Ferreira, Adalto Farias, Fabrizio Leonardi, Ed C. Bordinassi, Roberto Bortolussi, Sergio Delijaicov   +5 more
doaj   +1 more source

Numerical Study on Characteristics of Stick-Slip Instability of Coal-Rock Parting-Coal Structure under Lateral Unloading [PDF]

Lithosphere
Unloading excavation can increase the possibility of rock burst, especially for coal seam with rock parting. In order to explore the evolution process of rock burst under lateral unloading, the combination of in situ measures and numerical experiments is
Heng Zhang, Guang-Jian Liu, Xian-Jun Ji, Wen-Hao Cao, Ya-Wei Zhu, Sher Bacha   +5 more
doaj   +1 more source

Stick‐Slip Tremor Beneath an Alpine Glacier

Geophysical Research Letters, 2021
Sliding of glacial ice over its base is typically described by a frictionless or slowly deforming bed. This view is challenged by recent seismic observations of stick‐slip motion at the ice‐bed interface.
J. Umlauft, F. Lindner, P. Roux, T. D. Mikesell, M. M. Haney, M. Korn, F. T. Walter   +6 more
doaj   +1 more source

Dynamic Spectral Analysis of the Stick-Slip Effects in “Oral” Tribology Measurements [PDF]

, 2016
“Oral” tribology, associated with oral surface movement and friction, is a new tool to understand complex texture attributes such as “creamy, oily and astringent” which could not be successfully characterized by bulk texture analysis or by rheology ...
Upadhyay, Rutuja, Sanahuja, Solange, Briesen, Heiko, Chen, Jianshe   +3 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source

Numerical simulations of fault stick–slip characteristics in different temperature fields at laboratory scale

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
With the increasing demand for deep engineering development, there is an urgent need to study the evolution and formation mechanisms of the stick–slip process in faults at high temperatures.
Ke Ma, Yong Zhao, Qianbai Zhao, Haijun Xie, Jingrui Li   +4 more
doaj   +1 more source