Results 191 to 200 of about 31,588 (256)

Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation

Biomedicine and Pharmacotherapy, 2022
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Although its pathogenesis remains unclear, studies have indicated microglia-mediated neuroinflammation playing an important role.
Bowen Yang, Lipeng Wu, Baiyi Lu
exaly   +2 more sources

Stigmasterol: An Enigmatic Plant Stress Sterol with Versatile Functions

International Journal of Molecular Sciences
Sterols play important structural and regulatory roles in numerous intracellular processes. Unlike animals, plants contain a distinctive and diverse variety of sterols.
Richard P Beckett, F V Minibayeva
exaly   +2 more sources

Stigmasterol regulates microglial M1/M2 polarization via the TLR4/NF‐κB pathway to alleviate neuropathic pain

Phytotherapy Research, 2023
(Switching from the microglial M1 phenotype to the M2 phenotype is a promising therapeutic strategy for neuropathic pain (NP). This study aimed to investigate the potential use of stigmasterol for treating NP.
Waimei Si, Xin Li, Bei Jing, Shiquan Chang, Yachun Zheng, Zhenni Chen, Guoping Zhao, Di Zhang   +7 more
semanticscholar   +1 more source

Stigmasterol: Remodeling gut microbiota and suppressing tumor growth through Treg and CD8+ T cells in hepatocellular carcinoma.

Phytomedicine, 2023
BACKGROUND Hepatocellular carcinoma (HCC), the most primary malignant liver tumor and is ranked as the fifth most common malignancy worldwide. Despite various therapeutic approaches being used in clinical practice, the overall effectiveness remains ...
Ran Huo, Wenjing Yang, Yu Liu, Te Liu, Tong Li, Chuyu Wang, Bai-Shen Pan, Bei-Li Wang, Wei Guo   +8 more
semanticscholar   +1 more source

A Comprehensive Update on Phytochemistry, Analytical Aspects, Medicinal Attributes, Specifications and Stability of Stigmasterol.

Steroids, 2023
Phytosterols are bioactive substances naturally found in plant cell membranes, and their chemical structure is comparable to cholesterol found in mammalian cells.
Megha Goswami, Priya, S. Jaswal, G. Gupta, Sant Kumar Verma   +4 more
semanticscholar   +1 more source

Stigmasterol and its esters encapsulated in liposomes: Characterization, stability, and derivative formation

Food Chemistry
Dipalmitoylphosphatidylcholine liposomes were encapsulated with free stigmasterol (ST), stigmasteryl myristate (ME), and stigmasteryl oleate (OE). Their quality was determined using TEM, FT-IR spectroscopy, zeta potential and hydrodynamic diameter.
Magdalena Rudzinska, Katarzyna Cieslik-Boczula, Anna Grygier   +2 more
exaly   +2 more sources

Molecular dynamics study of stigmasterol and beta-sitosterol of Morinda citrifolia L. towards α-amylase and α-glucosidase

Journal of Biomolecular Structure and Dynamics, 2023
Previous in vivo studies of Morinda citrifolia (Rubiaceae) reported that the extract inhibited α-amylase and reduced blood glucose levels in streptozotocin-induced diabetes mice.
N. Lolok, Adi Sumiwi, Dwi Syah, Fitra Ramadhan, J. Levita, I. Sahidin   +5 more
semanticscholar   +1 more source

Stigmasterol can be new steroidal drug for neurological disorders: Evidence of the GABAergic mechanism via receptor modulation

Phytomedicine, 2021
Nasiara Karim, Abeer Abdelhalim, Sobia Ahsan Halim   +2 more
exaly   +2 more sources

Stigmasterol hemihydrate

Acta Crystallographica Section C Crystal Structure Communications, 2002
The title compound, stigmasta-5,22-dien-3beta-ol hemihydrate, C(29)H(48)O x 0.5H(2)O, previously thought to be the monohydrate, has two sterol molecules and one water molecule in the asymmetric unit. In both sterol molecules, the methyl group of the ethyl substituent at the end of the hydrocarbon chain is disordered over two sites.
Gloria A, Benavides, Frank R, Fronczek, Nikolaus H, Fischer   +2 more
openaire   +2 more sources