Results 1 to 10 of about 15,042 (221)
Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol [PDF]
Antioxidants, 2021 Phytosterols, which are present in a variety of foods, exhibit various physiological functions and do not have any side effects. Here, we attempted to identify functional role of campesterol in regulation of oxidative stress by leading to cell death of ...
Hyocheol Bae +2 more
exaly +5 more sources
Engineering Yarrowia lipolytica for Campesterol Overproduction. [PDF]
PLoS ONE, 2016 Campesterol is an important precursor for many sterol drugs, e.g. progesterone and hydrocortisone. In order to produce campesterol in Yarrowia lipolytica, C-22 desaturase encoding gene ERG5 was disrupted and the heterologous 7-dehydrocholesterol ...
Hao-Xing Du +6 more
doaj +4 more sources
Integrative Metabolomics and Systems Pharmacology Reveal PPARγ-Centered Antidiabetic Mechanisms of Caulerpa racemosa and Its Bioactive Compounds [PDF]
Marine DrugsType 2 diabetes mellitus (T2DM) is a complex metabolic disorder requiring safe, multitarget therapeutic strategies. Marine macroalgae represent an underexplored source of bioactives with pleiotropic metabolic effects.
Fahrul Nurkolis +11 more
doaj +2 more sources
Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β‐Hydroxycholesterol in Osteoporosis [PDF]
LipidsABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He +4 more
openaire +3 more sources
Phytosterols: From Preclinical Evidence to Potential Clinical Applications
Frontiers in Pharmacology, 2021 Phytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition.
Bahare Salehi +18 more
doaj +1 more source
Frontiers in Environmental Science, 2022 Phytoremediation is gaining interest in recent years as it is a simple and effective strategy for heavy metal decontamination. The most straightforward strategy for successful heavy metal clean-up is searching for efficient hyperaccumulator species that ...
Ekta Bhattacharya, Suparna Mandal Biswas
doaj +1 more source
Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production
Biomolecules, 2021 24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
doaj +1 more source
Molecules, 2021 Cannabis sativa L. has been used for a long time to obtain food, fiber, and as a medicinal and psychoactive plant. Today, the nutraceutical potential of C.sativa is being increasingly reappraised; however, C.
Fabio Ferrini +7 more
doaj +1 more source
Plants, 2023 The prevalence of benign prostatic hyperplasia (BPH) markedly increases with age. Phytotherapeutic approaches have been developed over time owing to the adverse side effects of conventional medications such as 5-reductase inhibitors and α1-adrenergic ...
Mădălina-Georgiana Buț +6 more
doaj +1 more source
Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects
International Journal of Molecular Sciences, 2022 Background: Increased cholesterol absorption and reduced synthesis are processes that have been associated with cardiovascular disease risk in a controversial way. However, most of the studies involving markers of cholesterol synthesis and absorption include conditions, such as obesity, diabetes, dyslipidemia, which can be confounding factors.
Valéria Sutti Nunes +9 more
openaire +2 more sources