Results 1 to 10 of about 15,568 (207)

Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

Drug Design, Development and Therapy, 2015
Huma Ali,1 Savita Dixit,1 Daoud Ali,2 Saeed M Alqahtani,3 Saad Alkahtani,2 Saud Alarifi2 1Department of Chemistry, Maulana Azad National Institute of Technology, Bhopal, India; 2Department of Zoology, College of Science, King Saud University, Riyadh ...
Ali H, Dixit S, Ali D, Alqahtani SM, Alkahtani S, Alarifi S   +5 more
doaj   +1 more source

Gene Silencing and Over-Expression Studies in Concurrence With Promoter Specific Elicitations Reveal the Central Role of WsCYP85A69 in Biosynthesis of Triterpenoids in Withania somnifera (L.) Dunal

Frontiers in Plant Science, 2019
Withania somnifera (Ashwagandha) synthesizes a wide spectrum of triterpenoids that are produced via an intricate isoprenoid pathway whose biosynthetic and regulatory mechanism remains elusive.
Arti Sharma, Gulzar A. Rather, Prashant Misra, Manoj K. Dhar, Surrinder K. Lattoo   +4 more
doaj   +1 more source

Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis

Open Life Sciences
Intervertebral disc degeneration (IVDD) is a core factor in spinal degeneration. To date, there is no effective treatment for IVDD. It is urgent to identify the pathogenesis of IVDD to develop effective strategies for IVDD treatment. Alleviating endplate
Li Hao, Chen Xiaofeng, Huang Baoci, He Junjie, Xie Junxian, Guo Weijun, Liang Jinjun, Ruan Jiajian, Liu Jincheng, Xiang Zhen, Zhu Lixin   +10 more
doaj   +1 more source

A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis and Smith-Lemli-Opitz syndrome

Journal of Lipid Research
Disease-specific sterols accumulate in the blood of patients with several rare lipid disorders. Biochemical measurement of these sterols is important for correct diagnosis and sometimes monitoring of treatment.
Alexander Bauer Westbye, Lili L. Dizdarevic, Sandra R. Dahl, Emil Andreas Asprusten, Yngve Thomas Bliksrud, Anita Lövgren Sandblom, Ulf Diczfalusy, Per M. Thorsby, Kjetil Retterstøl   +8 more
doaj   +1 more source

Antidiabetic potential of isolated compounds from Cyperus sexangularis Nees: An in silico molecular docking and dynamic-based approach [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Diabetes is a metabolic and chronic inflammatory disease that affects over 537 million people worldwide, with a projected rise to 783 million cases by 2045 if not put in check.
Gugulethu M. Miya, Pallab Kar, Ayodeji O. Oriola, Adebola O. Oyedeji   +3 more
doaj   +1 more source

Antimalarial Evaluation of the Chemical Constituents of Hairy Root Culture of Bixa orellana L.

Molecules, 2014
Over 216 million malaria cases are reported annually worldwide and about a third of these cases, primarily children under the age of five years old, will not survive the infection.
Bo Zhai, Julie Clark, Taotao Ling, Michele Connelly, Fabricio Medina-Bolivar, Fatima Rivas   +5 more
doaj   +1 more source

The Bioactivity Study of Active Compounds in Wolffia globosa Extract for an Alternative Source of Bioactive Substances

Cosmetics, 2017
Wolffia globosa is a small plant found in the lagoons in tropical zones. The aim of our study was to examine the biological compounds found in W. globosa and their activities. The substances in W.
Supannee Tipnee, Aranya Jutiviboonsuk, Paveena Wongtrakul   +2 more
doaj   +1 more source

Scientific Opinion on the safety of stigmasterol‐rich plant sterols as food additive

EFSA Journal, 2012
The Panel on Food Additives and Nutrient Sources added to Food (ANS) delivers a scientific opinion evaluating the safety of use of stigmasterol‐rich plant sterols in ready‐to‐freeze alcoholic cocktails as a stabiliser.
EFSA Panel on Food additives and Nutrient Sources added to Food (ANS)
doaj   +1 more source

EKSTRAKSI DAN ANALISIS FITOSTEROL LEMBAGA GANDUM [Extraction and analysis of Phytosterol from wheat germ (Triticum sp.)]

Jurnal Teknologi dan Industri Pangan, 2005
Phytosterol may reduce the absorption of cholesterol, and used for preventing atherosclerosis. It is limited in soybean, but potentially abundant in wheat germ. Research on the utilization of wheat germ sterol had not been reported so far.
Latifah K Darusman3), Deddy Muchtadi2), Hidayat Syarief1), Sri Anna Marliyati1), Rimbawan Rimbawan1)   +4 more
doaj  

Effect of gastrointestinal digestion on the stability and cytotoxicity of conventional and pegylated liposomes encapsulated with stigmasterol and its esters

Scientific Reports
Conventional and PEGylated liposomes encapsulated with stigmasterol and its esters were prepared, and their stability and cytotoxicity during in vitro gastrointestinal digestion were determined. The release of stigmasterol and its oxidation products were
Magdalena Rudzińska, Anna Grygier, Anna Olejnik, Katarzyna Kowalska, Joanna Igielska-Kalwat, Dominik Kmiecik, Katarzyna Cieślik-Boczula   +6 more
doaj   +1 more source