Results 1 to 10 of about 2,892 (211)

Plasma lathosterol measures rates of cholesterol synthesis and efficiency of dietary phytosterols in reducing the plasma cholesterol concentration

Clinics, 2022
Objectives Because the plasma campesterol/cholesterol ratio does not differ between groups that absorb different amounts of cholesterol, the authors investigated whether the plasma Phytosterols (PS) relate to the body's cholesterol synthesis rate ...
Valéria S Nunes, Renata de Paula Assis Bombo, Milessa S Afonso   +2 more
exaly   +7 more sources

Age-related changes of cholestanol and lathosterol plasma concentrations: an explorative study [PDF]

Lipids in Health and Disease, 2019
Background Cerebrotendinous xanthomatosis (CTX) and Lathosterolosis represent two treatable inherited disorders of cholesterol metabolism that are characterized by the accumulation of cholestanol and lathosterol, respectively.
Monica Gelzo, Maria Donata Di Taranto, Concetta Sica, Antonio Boscia, Francesco Papagni, Giuliana Fortunato, Gaetano Corso, Antonio Dello Russo   +7 more
doaj   +5 more sources

Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. [PDF]

Journal of Lipid Research, 1988
The power of serum lathosterol concentration as an indicator of whole-body cholesterol synthesis was investigated in 47 human volunteers consuming two diets differing in fatty acid composition. The cholesterol balance (fecal excretion of neutral and acid
H J Kempen, J F Glatz, J A Gevers Leuven, H A van der Voort, M B Katan   +4 more
doaj   +5 more sources

Effect of Desmosterol, Lathosterol and Coprostanol on the phase behaviour of phospholipid membranes

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023
Sterols have played an important role in membrane evolution. The effect of these molecules, particularly the naturally occurring ones, such as cholesterol, ergosterol, lanosterol, phytosterols and oxysterols on the prop-erties of lipid model membranes have been extensively investigated.
Mohammad Arif Kamal, Antara Pal
exaly   +4 more sources

Genetic analysis of indicators of cholesterol synthesis and absorption: Lathosterol and phytosterols in Dutch twins and their parents [PDF]

Twin Research, 2003
Significant familial aggregation was observed for plasma levels of lathosterol (an indicator of whole-body cholesterol synthesis) and plant sterols campesterol and β-sitosterol (indicators of cholesterol absorption) in 160 Dutch families consisting of ...
Boomsma, D.I., Frants, R.R., Gevers Leuven, J.A., Kempen, H.J.M., Princen, H.M.G.   +4 more
core   +6 more sources

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures [PDF]

Compr Physiol
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Li Y, Wang Y, Wang B, Ouyang Q, Liu W, Xu X, Zhang X, Liu M, Xiu R.   +8 more
europepmc   +2 more sources

Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits.

Journal of Lipid Research, 1992
Serum lathosterol concentration in rabbits was assessed as a possible indicator of whole-body cholesterol synthesis. In random-bred New Zealand White (NZW) rabbits fed a control diet or a diet containing either cholesterol, simvastatin, or cholestyramine,
GW Meijer, JG Van der Palen, H De Vries, HJ Kempen, HA Van der Voort, LF Van Zutphen, AC Beynen   +6 more
doaj   +4 more sources

α-Tocopherol modulates the low density lipoprotein receptor of human HepG2 cells [PDF]

Nutrition Journal, 2003
The aim of this study was to determine the effects of vitamin E (α-tocopherol) on the low density lipoprotein (LDL) receptor, a cell surface protein which plays an important role in controlling blood cholesterol. Human HepG2 hepatoma cells were incubated
Bottema Cynthia DK, Thomson Andrew M, Pal Sebely, Roach Paul D   +3 more
doaj   +3 more sources

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation. [PDF]

J Neurochem
The authors induced damage in iPSC‐derived motor neurons through gradual oxidative stress by culturing them without antioxidants. Neurons underwent ferroptosis‐dependent cell death, which was inhibited by edaravone. Additionally, the authors revealed neuroprotective activity in a cholesterol metabolite and a sterol pathway inhibitor, suggesting that ...
Kobayashi H, Suzuki-Masuyama H, Tanabe H, Kato H, Endoh-Yamagami S.   +4 more
europepmc   +2 more sources

Anagliptin decreases serum lathosterol level in patients with type 2 diabetes: a pilot study [PDF]

Expert Opinion on Pharmacotherapy, 2015
The mechanism responsible for the lipid-lowering effect of dipeptidyl peptidase-4 (DPP-4) inhibitors remains unknown in humans. We evaluated the effect of anagliptin on serum lipid profiles, including cholesterol synthesis and absorption markers, in Japanese patients with type 2 diabetes.Thirty patients with type 2 diabetes (20 - 70 years old, low ...
Yasuo Terauchi
exaly   +3 more sources