Results 1 to 10 of about 204 (101)

Plasma lathosterol measures rates of cholesterol synthesis and efficiency of dietary phytosterols in reducing the plasma cholesterol concentration

Clinics, 2022
Objectives Because the plasma campesterol/cholesterol ratio does not differ between groups that absorb different amounts of cholesterol, the authors investigated whether the plasma Phytosterols (PS) relate to the body's cholesterol synthesis rate ...
Guilherme Ferreira, Quintao Ec, Ana Maria Lottenberg   +2 more
exaly   +7 more sources

Age-related changes of cholestanol and lathosterol plasma concentrations: an explorative study [PDF]

Lipids in Health and Disease, 2019
Background Cerebrotendinous xanthomatosis (CTX) and Lathosterolosis represent two treatable inherited disorders of cholesterol metabolism that are characterized by the accumulation of cholestanol and lathosterol, respectively.
Monica Gelzo, Maria Donata Di Taranto, Concetta Sica, Antonio Boscia, Francesco Papagni, Giuliana Fortunato, Gaetano Corso, Antonio Dello Russo   +7 more
doaj   +5 more sources

Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. [PDF]

Journal of Lipid Research, 1988
The power of serum lathosterol concentration as an indicator of whole-body cholesterol synthesis was investigated in 47 human volunteers consuming two diets differing in fatty acid composition. The cholesterol balance (fecal excretion of neutral and acid
H J Kempen, J F Glatz, J A Gevers Leuven, H A van der Voort, M B Katan   +4 more
doaj   +5 more sources

Effect of Desmosterol, Lathosterol and Coprostanol on the phase behaviour of phospholipid membranes

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023
Sterols have played an important role in membrane evolution. The effect of these molecules, particularly the naturally occurring ones, such as cholesterol, ergosterol, lanosterol, phytosterols and oxysterols on the prop-erties of lipid model membranes have been extensively investigated.
Mohammad Arif Kamal, Antara Pal
exaly   +4 more sources

Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits.

Journal of Lipid Research, 1992
Serum lathosterol concentration in rabbits was assessed as a possible indicator of whole-body cholesterol synthesis. In random-bred New Zealand White (NZW) rabbits fed a control diet or a diet containing either cholesterol, simvastatin, or cholestyramine,
GW Meijer, JG Van der Palen, H De Vries, HJ Kempen, HA Van der Voort, LF Van Zutphen, AC Beynen   +6 more
doaj   +4 more sources

Anagliptin decreases serum lathosterol level in patients with type 2 diabetes: a pilot study [PDF]

Expert Opinion on Pharmacotherapy, 2015
The mechanism responsible for the lipid-lowering effect of dipeptidyl peptidase-4 (DPP-4) inhibitors remains unknown in humans. We evaluated the effect of anagliptin on serum lipid profiles, including cholesterol synthesis and absorption markers, in Japanese patients with type 2 diabetes.Thirty patients with type 2 diabetes (20 - 70 years old, low ...
Yasuo Terauchi, Kazutaka Aoki, Hiroshi Kamiyama   +2 more
exaly   +3 more sources

Studies in hypertriglyceridaemia VI: serum lathosterol concentration is raised in hypertriglyceridaemic non‐diabetic males with hyperinsulinaemia [PDF]

Journal of Internal Medicine, 1999
Abstract.Objectives. To assess the cholesterol synthesis rate in primary hypertriglyceridaemia using the serum unesterified lathosterol concentration as an indicator.Design. A cross‐sectional, case–control study.Setting. The Karolinska Hospital, Stockholm.Subjects. Randomly selected hyper‐ (n = 53) and normotriglyceridaemic (n = 57) males, 40–50 years,
Ingemar Björkhem
exaly   +3 more sources

Prognostic significance of serum cholesterol, lathosterol, and sitosterol in old age; a 17-year population study

Annals of Medicine, 2011
BACKGROUND. Low serum total cholesterol is frequently associated with worse survival in older people, but mechanisms of this association are poorly understood. AIMS. Characteristics of cholesterol metabolism were related to survival in a random 75 + population sample. METHODS.
Timo Einar Strandberg, Reijo S Tilvis
exaly   +3 more sources

Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency [PDF]

Human Molecular Genetics, 2003
Lathosterol 5-desaturase catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholesterol synthesis. Inborn errors of cholesterol synthesis underlie a group of human malformation syndromes including Smith-Lemli-Opitz syndrome, desmosterolosis, CHILD syndrome, CDPX2 and lathosterolosis. We disrupted the lathosterol
Martina Kovarova, Maria Tsokos, Forbes D Porter   +2 more
exaly   +3 more sources

Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non‐dialysis CKD: An observational study

Pharmacology Research & Perspectives, 2021
In dialysis patients, cholesterol‐lowering therapy with statins is less effective than in other high‐risk patients. This may be explained by a shift from cholesterol synthesis toward cholesterol absorption. In line, markers of cholesterol absorption—such
Insa E. Emrich, Gunnar H. Heine, P. Christian Schulze, Kyrill S. Rogacev, Danilo Fliser, Stefan Wagenpfeil, Michael Böhm, Dieter Lütjohann, Oliver Weingärtner   +8 more
doaj   +1 more source