Results 11 to 20 of about 1,616 (166)

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures [PDF]

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Yuan Li, Yingyu Wang, Bing Wang, Qin Ouyang, Weiqi Liu, Xiang Xu, Xu Zhang, Mingming Liu, Ruijuan Xiu   +8 more
wiley   +2 more sources

High cholesterol absorption efficiency enhances proatherogenic properties of low‐density lipoprotein particles [PDF]

Journal of Internal Medicine, Volume 299, Issue 6, Page 711-725, June 2026.
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Katariina Öörni, Lauri Äikäs, Maija Ruuth, Feven Tigistu‐Sahle, Reijo Käkelä, Ingmar Wester, Helena Gylling, Piia Simonen   +7 more
wiley   +2 more sources

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC‐Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation [PDF]

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
The authors induced damage in iPSC‐derived motor neurons through gradual oxidative stress by culturing them without antioxidants. Neurons underwent ferroptosis‐dependent cell death, which was inhibited by edaravone. Additionally, the authors revealed neuroprotective activity in a cholesterol metabolite and a sterol pathway inhibitor, suggesting that ...
Hayato Kobayashi, Hitoshi Suzuki‐Masuyama, Hirokazu Tanabe, Hiroshi Kato, Setsu Endoh‐Yamagami   +4 more
wiley   +2 more sources

Novel ABCG5 and ABCG8 Variants in Sitosterolemia: Insights Into Haemolysis, Calcium Dysregulation and Therapeutic Challenges [PDF]

Human Mutation, Volume 2026, Issue 1, 2026.
Sitosterolemia is a rare autosomal recessive lipid metabolic disorder caused by mutations in ABCG5 or ABCG8, leading to pathological accumulation of dietary plant sterols. The condition is clinically heterogeneous, presenting with xanthomas, premature atherosclerosis and haematological abnormalities such as stomatocytosis, haemolytic anaemia and ...
Prashant Warang, Rashmi Dongerdiye, Pradnya Dehadrai, Prachi Kamble, Neha Samanpalliwar, Manisha Madkaikar, Chandrakala Shanmukhaiah, Prabhakar S. Kedar, Harleen Khatra   +8 more
wiley   +2 more sources

Presence of Cholesterol in Non-Animal Organisms: Identification and Quantification of Cholesterol in Crude Seed Oil from Perilla frutescens and Dehydrated Pyropia tenera

Molecules, 2021
Studies have reported that cholesterol, a molecule found mainly in animals, is also present in some plants and algae. This study aimed to determine whether cholesterol exists in three dehydrated algae species, namely, Pyropia tenera, Saccharina japonica,
Min-Ji Oh, Hee-Jin So, Eun-Sik Hong, Jung-Ah Shin, Ki-Teak Lee   +4 more
doaj   +1 more source

Plasma Cholesterol and Lathosterol Levels in Term Infants in the Early Neonatal Period [PDF]

Pediatric Research, 1992
Plasma cholesterol concentrations increase after birth. Whether this is due to increased cholesterol synthesis has not been reported. Additionally, it is not known if formulas, which lack cholesterol, result in higher rates of cholesterol synthesis than feeding breast milk.
J J, Hamilton, A, Synnes, S M, Innis
openaire   +2 more sources

Serum lathosterol levels in human subjects reflect changes in whole body cholesterol synthesis induced by lovastatin but not dietary cholesterol.

Journal of Lipid Research, 1995
We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day); 2 ...
W C Duane
doaj   +1 more source

Metabolism of lathosterol byDrosophila pachea

Lipids, 1971
AbstractDrosophila pachea is a Sonoran Desert cactiphilic species unable to utilize cholesterol or cholestanol for larval growth and maturation. Lathosterol (7‐cholesten‐3β‐ol) was added to a sterol deficient medium on which an axenic culture ofD. pachea was maintained.
K C, Goodnight, H W, Kircher
openaire   +2 more sources

High levels of plant sterols and cholesterol precursors in cerebrotendinous xanthomatosis.

Journal of Lipid Research, 1991
We measured the cholestanol, cholesterol precursor (lathosterol), and plant sterol (campesterol and sitosterol) concentrations of serum and bile in 11 patients with cerebrotendinous xanthomatosis.
M Kuriyama, J Fujiyama, T Kasama, M Osame   +3 more
doaj   +1 more source

Defective conversion of 7-dehydrocholesterol to cholesterol in cultured skin fibroblasts from Smith-Lemli-Opitz syndrome homozygotes

Journal of Lipid Research, 1995
The Smith-Lemli-Opitz syndrome is a common birth defect syndrome characterized biochemically by low plasma cholesterol levels and high concentrations of the cholesterol precursor 7-dehydrocholesterol.
A Honda, G S Tint, G Salen, A K Batta, T S Chen, S Shefer   +5 more
doaj   +1 more source