Results 111 to 120 of about 4,864,129 (252)
Adult Onset Still's Disease - current state of knowledge
Journal of Education, Health and SportIntroduction: Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. AOSD lies at the crossroads of innate and adaptive immunity, highlighting the complexity of its pathogenesis.
Anna Centkowska +9 more
doaj +1 more source
Still’s Disease – Unlikely Diagnosis on the Old Age
, 2019 Adult Still’s Disease is a rare systemic inflammatory disease. It is characteristically identified in the young adult, with few cases described in older patients. The aetiology and pathogenesis remain unknown.
Fernandes, Tiago Manuel +2 more
core
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Early IL‐1 Inhibition in Still's Disease: A Window of Opportunity for Improving Outcomes
ACR Open RheumatologyObjective Still's disease is a complex, multisystemic disorder requiring prompt diagnosis and treatment. This study provides a general assessment of a Still's disease cohort aiming to evaluate the efficacy of early intervention with interleukin‐1 ...
Sara Bindoli +5 more
doaj +1 more source
EULAR Rheumatology Open: Objectives: Adult-onset Still’s disease presents with nonspecific and heterogeneous features. This study aims to elucidate the development of initial symptoms and their relationship with the disease course in adult-onset Still’s disease.
Hiroya Tamai +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Cryoglobulinemia vasculitis associated with adult‐onset Still's disease
Clinical Case ReportsKey Clinical Message The present case indicates that cryoglobulinemia vasculitis should be considered in the differential diagnosis of purpura in patients with adult‐onset Still's disease (AOSD).
Noriharu Nakagawa +3 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Multiplexed imaging data associated with "IFNγ-Expressing Myeloid Cells Localize within Lipoproteinosis during Pulmonary Alveolar Proteinosis occurring in Still’s ...
Delmastro, Alea
core +1 more source