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Redox modulation of STIM-ORAI signaling [PDF]
Cell Calcium, 2016 STIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry pathway and loss of function in these proteins is associated with severe immune and muscular disorders.
Rajesh Bhardwaj +2 more
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The STIM-Orai Pathway: The Interactions Between STIM and Orai
Advances in Experimental Medicine and Biology, 2017A primary Ca2+ entry pathway in non-excitable cells is established by the Ca2+ release-activated Ca2+ channels. Their two limiting molecular components include the Ca2+-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane.
Marc Fahrner +2 more
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Proceedings of the 14th International Conference on Information Processing in Sensor Networks, 2015
Globally, infrastructure is a vital asset for economic prosperity, but condition assessments tend to be subjective and infrequent [2]. The lack of objective information leads to sub-optimal capital replacement projects, and the information lag prevents timely repair. In this poster we focus on techniques for monitoring rail-based transit infrastructure,
George Lederman +2 more
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Globally, infrastructure is a vital asset for economic prosperity, but condition assessments tend to be subjective and infrequent [2]. The lack of objective information leads to sub-optimal capital replacement projects, and the information lag prevents timely repair. In this poster we focus on techniques for monitoring rail-based transit infrastructure,
George Lederman +2 more
openaire +2 more sources
SPIE Proceedings, 2003
n order to studying long-term climate variability and globe environment change, Solar Total Irradiance Monitor (STIM) is constructed planed to aboard on FY-3 sun-synchronous polar orbit weather satellites. STIM is made up of three same absolute radiometers, which are similar with Solar Irradiance Absolute Radiometers (SIAR). We designate one radiometer
Wei Fang +5 more
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n order to studying long-term climate variability and globe environment change, Solar Total Irradiance Monitor (STIM) is constructed planed to aboard on FY-3 sun-synchronous polar orbit weather satellites. STIM is made up of three same absolute radiometers, which are similar with Solar Irradiance Absolute Radiometers (SIAR). We designate one radiometer
Wei Fang +5 more
openaire +1 more source
Molecular mechanisms of STIM/Orai communication [PDF]
American Journal of Physiology - Cell Physiology, 2016 Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels triggers diverse signaling cascades that affect cellular processes like cell growth, gene regulation, secretion, and cell death. These store-operated Ca2+ channels open after depletion of intracellular Ca2+ stores, and their main features are fully reconstituted by
Isabella Derler +2 more
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STIM and Orai in cellular proliferation and division
Frontiers in Bioscience - Elite, 2012 Cellular proliferation and division are central processes in the development, survival and evolution of living systems. Transitioning into the cell division phase of the cell cycle encompasses dramatic remodeling of cellular organelles and signaling modules including Ca2+ signaling.
Khaled Machaca, Raphaël Courjaret
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The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
2017Considerable progress has been made elucidating the molecular mechanisms of calcium (Ca2+) sensing by stromal interaction molecules (STIMs) and the basis for Orai channel activity. This chapter focuses on the available high-resolution structural details of STIM and Orai proteins with respect to the regulation of store-operated Ca2+ entry (SOCE ...
Jinhui, Zhu +2 more
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STIM and Orai in platelet function
Cell Calcium, 2011Physiological platelet activation and thrombus formation are essential to stop bleeding in case of vascular injury, whereas inadequate triggering of the same process in diseased vessels can lead to fatal thromboembolism and tissue ischemia of vital organs.
David, Varga-Szabo +2 more
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The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
2017Cysteines are among the least abundant amino acids found in proteins. Due to their unique nucleophilic thiol group, they are able to undergo a broad range of chemical modifications besides their known role in disulfide formation, such as S-sulfenylation (-SOH), S-sulfinylation (-SO(2)H), S-sufonylation (-SO(3)H), S-glutathionylation (-SSG), and S ...
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To stim, or not to stim, that is the question
The American Journal of Surgery, 2022Eric J. Kuo, James A. Lee
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