Results 71 to 80 of about 43,138 (232)

Bridging computational and clinical strategies for presurgical identification of epileptogenic networks

Epilepsia Open, EarlyView.
Abstract Objective About one third of epilepsy patients are drug‐resistant. Resective epilepsy surgery remains a key treatment option but depends critically on accurate identification of the seizure onset zone (SOZ), which is still guided mainly by subjective visual inspection of electrophysiological signals.
Tena Dubcek, Debora Ledergerber, Kristina Koenig, Adham Elshahabi, Rafael Polania, Lukas Imbach   +5 more
wiley   +1 more source

Soluble TIM-3, likely produced by myeloid cells, predicts resistance to immune checkpoint inhibitors in metastatic clear cell renal cell carcinoma

Journal of Experimental & Clinical Cancer Research
Background Immunotherapies targeting PD-1 and CTLA-4 are key components of the treatment of metastatic clear cell renal cell carcinoma (mccRCC). However, they have distinct safety profiles and resistance to treatment can occur.
Ivan Pourmir, Nadine Benhamouda, Thi Tran, Hugo Roux, Joséphine Pineau, Alain Gey, Andyara Munoz, Nesrine Mabrouk, Nicolas Epaillard, Virginie Verkarre, Yann-Alexandre Vano, Eric Tartour, Stéphane Oudard   +12 more
doaj   +1 more source

Soluble TIM-3 and galectin-9 predict survival in gastric and gastroesophageal junction cancer

iScience
Summary: Current biomarkers for diagnosis and prognosis prediction in gastric cancer (GC) and gastroesophageal junction (GEJ) cancer have limited accuracy, and the role of soluble immune checkpoints is unknown.
David Digomann, Charlotte Reiche, Antonia Stammberger, Tido Willms, Loreen S. Rudek, Anders Grabenkamp, Anna Klimova, Jamie Kölbel, Felix Merboth, Loreen Natusch Bufe, Carolin Beer, Therés Golle, Sarah Cronjaeger, Franziska Hoffmann, Luisa Kranich, Marc Schmitz, Christiane J. Bruns, Hans A. Schlößer, Jürgen Weitz, Lena Seifert, Adrian M. Seifert   +20 more
doaj   +1 more source

STIM calcium sensing and conformational change [PDF]

The Journal of Physiology, 2019
AbstractThe control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER.
Aparna Gudlur, Ana Eliza Zeraik, Nupura Hirve, Patrick G. Hogan   +3 more
openaire   +2 more sources

Understanding Autistic Young Adults' Perceptions and Experiences of Traumatic and Stressful Events

Journal of Clinical Psychology, Volume 81, Issue 6, Page 445-461, June 2025.
ABSTRACT Objectives The aim of this study was to explore how young autistic adults experience and respond to stressful life events, and the relationship between autistic characteristics and symptoms of stress associated with these events. Methods Using an exploratory sequential mixed‐methods approach, an online qualitative survey was first administered
Alliyza Lim, Robyn L. Young
wiley   +1 more source

Association of soluble T cell immunoglobulin domain and mucin-3 (sTIM-3) and mac-2 binding protein glycosylation isomer (M2BPGi) in patients with autoimmune hepatitis.

PLoS ONE, 2020
BackgroundAutoimmune hepatitis (AIH) is a disorder of unknown etiology in which immune-mediated liver injury progress to cirrhosis or hepatocellular carcinoma (HCC).
Kiyoshi Migita, Minoru Nakamura, Yoshihiro Aiba, Hideko Kozuru, Seigo Abiru, Atsumasa Komori, Yuya Fujita, Junpei Temmoku, Tomoyuki Asano, Shuzo Sato, Makiko Furuya, Atsushi Naganuma, Kaname Yoshizawa, Masaaki Shimada, Keisuke Ario, Tomohiko Mannami, Hiroshi Kohno, Toshihiko Kaneyoshi, Takuya Komura, Hiromasa Ohira, Hiroshi Yatsuhashi   +20 more
doaj   +1 more source

7 T MRI Connectivity‐Guided Reprogramming Improves Deep Brain Stimulation Motor Outcome in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD). Using 7‐Tesla (7 T) MRI connectivity analysis to visualize the patient‐specific STN motor subdivision, we hypothesize that reprogramming patients who are stimulated outside of this subdivision can improve their ...
Yarit Wiggerts, Annabel van der Weide, Rick Schuurman, Pepijn van den Munckhof, Rob MA de Bie, Martijn Beudel, Maarten Bot   +6 more
wiley   +1 more source

STIMPROCESSEN : En fallstudie av STIM och dess insamlings- och fördelningsverksamhet

, 2008
Uppsatsens syfte är att ta reda på hur STIM:s insamlings- och fördelningsregler ser ut och ta reda på varför det är på det sättet, samt att undersöka ifall det finns några brister och hur de i sådant fall kan åtgärdas.
Westerlund, Christoffer, Csongvai, Jozsef, Karlsson, Jonas   +2 more
core   +3 more sources

Triple touch sperm immobilization vs. single touch sperm immobilization in ICSI - a randomised trial

Reproductive Biology and Endocrinology, 2012
Background Although different techniques for sperm immobilization have been described, their value has not been assessed in an adequately powered randomized study.
Velaers An, Paternot Goedele, Debrock Sophie, D’Hooghe Thomas, Spiessens Carl   +4 more
doaj   +1 more source

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia

Movement Disorders, EarlyView.
Abstract Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining brain oscillations, can transiently modulate neuronal activity and enhance resonant rhythms.
Davide Costa, Andrea Guerra, Daniele Birreci, Massimiliano Passaretti, Martina De Riggi, Anna Sofia Grandolfo, Valentina D'Onofrio, Luca Angelini, Giulia Paparella, Matteo Bologna   +9 more
wiley   +1 more source