Results 51 to 60 of about 40,978 (244)

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Le système STIM/LIPN à EQueR 2004, tâche médicale: Le système STIM/LIPN à EQueR 2004, tâche médicale [PDF]

, 2005
http://taln.limsi.fr/site/talnRecital05/tome2/P116.pdfWe present the principles of the question-answering system STIM/LIPN, the result of joint work by STIM (AP-HP & INSERM U729) and LIPN (CNRS & Université Paris 13), which participated in the medical ...
Berroyer, Jean-François, Zweigenbaum, Pierre, Delbecque, Thierry, Poibeau, Thierry   +3 more
core  

Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?

Chinese Journal of Cancer, 2016
The stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) play pivotal roles in the modulation of Ca2+-regulated pathways from gene transcription to cell apoptosis ...
Jing Wen, Ying-Cheng Huang, Huan-Huan Xiu, Zhi-Ming Shan, Kang-Qing Xu   +4 more
doaj   +1 more source

Serum checkpoint molecules in patients with IgG4-related disease (IgG4-RD)

Arthritis Research & Therapy, 2021
Background Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of IgG4+ plasma cells in the affected organs.
Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Eiji Suzuki, Sosuke Tsuji, Shoichi Fukui, Masataka Umeda, Naoki Iwamoto, Atsushi Kawakami, Kiyoshi Migita   +14 more
doaj   +1 more source

A Millimeter‐Scale Implantable Magneto–Mechano–Electric Transducer Based on BTO Piezoelectric Ceramics for Remote Wireless Electrical Stimulation of Injured Sciatic Nerves

Advanced Science, EarlyView.
We report a fully wireless, circuit‐free neural stimulator built on a millimetric magneto‐mechano‐electric (MME) cantilever transducer (3 × 10 × 5 mm) with a barium titanate (BTO) piezoelectric ceramic core. Under low‐frequency alternating magnetic fields, the MME cantilever mechanically oscillates, inducing stress on the BTO element and thereby ...
Yijing Wang, Jingyu Tian, Zhe Xu, Cuiling Zhang, Jingen Wu, Ming Liu, Zhilu Ye, Xiaohui Zhang   +7 more
wiley   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

STIM and Orai in hemostasis and thrombosis

Frontiers in Bioscience, 2011
At sites of vascular injury, platelets rapidly adhere to the exposed subendothelial extracellular matrix, become activated and, together with the coagulation system, form a plug that seals the lesion. This process is essential to prevent blood loss, however, under pathological conditions it may lead to vessel occlusion.
Attila, Braun, Timo, Vogtle, David, Varga-Szabo, Bernhard, Nieswandt   +3 more
openaire   +2 more sources

Localization of STIM-1 and Orai-1 in DC. [PDF]

, 2013
The expression of Orai-1 and STIM-1 was analyzed at the transcriptional (A and B) or translational (C) level. Quantitative RT-PCR analysis of Orai-1 (A) and STIM-1 (B) mRNA showed their expression profile for different maturating stimuli (mean ± SD). The
Jérémy Fauconnier (586768), Jean-Yves Le Guennec (314450), Yvon Lebranchu (94195), Romain Félix (586765), David Crottès (586766), Anthony Delalande (586767), Florence Velge-Roussel (94194)   +6 more
core   +1 more source

Artificial intelligence for adaptive neuromodulation in drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects nearly one third of people with epilepsy and is associated with substantial cognitive, psychiatric, and mortality burdens. For patients who are not candidates for resection or laser interstitial thermal therapy, neuromodulation therapies such as vagus nerve stimulation, deep brain stimulation, and ...
Amir Hossein Daraie, Arianna Damiani, Mahsa Khoshkhou, Luis A. Sanchez, Rachel J. Smith, Shruti H. Agashe, Jorge A. Gonzalez‐Martinez, Jennifer Hopp, Adam S. Charles, Sridevi V. Sarma, Joon‐Yi Kang   +10 more
wiley   +1 more source

Роль молекулярных компонентов депо-зависимого тока Ca2+ – белков Stim и Orai – в лимфоцитах [PDF]

, 2018
In the process of evolution of eukaryotes has formatted a highly organized mechanism for maintaining and regulating intracellular calcium homeostasis, which is one of the most important components of cell signaling in all branches of the phylogenetic ...
G. E. Gercog, E. V. Lychkovskaya, Г. Е. Герцог, L. V. Trufanova, L. B. Shadrina, Л. Б. Шадрина, Е. В. Лычковская, A. N. Shuvaev, Л. В. Труфанова, А. Н. Шуваев, А. Б. Салмина, A. B. Salmina, A. A. Semenchukov, А. А. Семенчуков   +13 more
core   +2 more sources