Results 61 to 70 of about 61,886,207 (255)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Regulation of ABCG1 expression in human keratinocytes and murine epidermis[S]

Journal of Lipid Research, 2010
ABCG1, a member of the ATP binding cassette superfamily, facilitates the efflux of cholesterol from cells to HDL. In this study, we demonstrate that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinocyte ...
Yan J. Jiang, Biao Lu, Elizabeth J. Tarling, Peggy Kim, M-Q. Man, Debbie Crumrine, Peter A. Edwards, Peter M. Elias, Kenneth R. Feingold   +8 more
doaj   +1 more source

Neural differentiation of canine mesenchymal stem cells/multipotent mesenchymal stromal cells

BMC Veterinary Research, 2020
Background The ability of adipose tissue-derived multipotent mesenchymal stromal cells/mesenchymal stem cells (ASCs) to differentiate in neural lineages promises progress in the field of regenerative medicine, especially for replacing neuronal tissue ...
Sonja Prpar Mihevc, Vesna Kokondoska Grgich, Andreja Nataša Kopitar, Luka Mohorič, Gregor Majdič   +4 more
doaj   +1 more source

Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps. [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Zhang QQ, Zhang C, Chen JN, Cheng FY, Wang YZ, Xue SR, Wang H, Wang DH, Sun XC, Hu L.   +9 more
europepmc   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Coordination of limb bud development : the role of SHH in PD limb bud patterning [PDF]

, 2012
The limb bud serves as an excellent model to investigate the signals involved in diverse processes during embryonic development. Limb bud development is controlled by complex regulatory networks that instruct coordinated patterning and proliferation of ...
Probst, Simone
core   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

The biological activity of retinoids in melanoma cells Induction of expression of retinoic acid receptor-β by retinoic acid in S91 melanoma cells [PDF]

, 1990
The expression of mRNA for retinoic acid receptor beta (RAR-β was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-β was dose-dependent, rapid and insensitive to cycloheximide.
Christopher F.F. Redfern, Latham, Julie A.E., Daly, Ann K., Redfern, Christopher F.F., Todd, Carole, Carole Todd, Ann K. Daly, Julie A.E. Latham   +7 more
core   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

All-Trans Retinoic Acid Stimulates Growth and Extracellular Matrix Production in Growth-Inhibited Cultured Human Skin Fibroblasts [PDF]

, 1990
All-trans retinoic acid was examined for effects on human dermal fibroblast proliferation and for effects on fibroblast production and expression of non-collagenous and collagenous components of the extracellular matrix in vitro. Fibroblast proliferation
Siebert, Karl J, Phan, Sem H, Voorhees, John J, Nickoloff, Brian J, Dixit, Vishva M, Mitra, Rajorshi, Varani, James, Gibbs, Douglas, Wang, Tamara, Mitra, Raj S   +9 more
core   +1 more source