Results 1 to 10 of about 53 (52)

Electronegative low‐density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade

Journal of Diabetes Investigation, 2020
Aims/Introduction Electronegative low‐density lipoprotein (L5) is the most atherogenic fraction of low‐density lipoprotein and is elevated in people with metabolic syndrome (MetS), whereas the retinol‐binding protein 4 receptor (stimulated by retinoic ...
Chao‐Hung Chen, Liang‐Yin Ke, Hua‐Chen Chan, Chih‐Sheng Chu, An‐Sheng Lee, Kun‐Der Lin, Mei‐Yueh Lee, Pi‐Jung Hsiao, Chu‐Huang Chen, Shyi‐Jang Shin   +9 more
doaj   +2 more sources

Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis

Cell & Bioscience, 2021
Background Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis.
Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon, Hyo-Soo Kim   +4 more
doaj   +1 more source

Adaptive evolution of the STRA6 genes in mammalian. [PDF]

PLoS ONE, 2014
Stimulated by retinoic acid 6 (STRA6) is the receptor for retinol binding protein and is relevant for the transport of retinol to specific sites such as the eye.
Jianghong Wu, Hui Xiang, Yunxia Qi, Ding Yang, Xiaojuan Wang, Hailian Sun, Feng Wang, Bin Liu   +7 more
doaj   +1 more source

To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses. [PDF]

PLoS ONE, 2013
Our earlier study revealed that STRA6 (stimulated by retinoic acid gene 6) was up-regulated within 3 h of TCR stimulation. STRA6 is the high-affinity receptor for plasma retinol-binding protein (RBP) and mediates cellular vitamin A uptake.
Rafik Terra, Xuehai Wang, Yan Hu, Tania Charpentier, Alain Lamarre, Ming Zhong, Hui Sun, Jianning Mao, Shijie Qi, Hongyu Luo, Jiangping Wu   +10 more
doaj   +1 more source

STRA6 Polymorphisms Are Associated With EGFR Mutations in Locally-Advanced and Metastatic Non-Small Cell Lung Cancer Patients

Frontiers in Oncology, 2020
Retinol plays a significant role in several physiological processes through their nuclear receptors, whose expression depends on retinol cytoplasmic concentration.
Saé Muñiz-Hernández, Jesús Bernardino Velázquez-Fernández, José Díaz-Chávez, Omar Mondragón-Fonseca, Yerye Mayén-Lobo, Yerye Mayén-Lobo, Alberto Ortega, Marisol López-López, Oscar Arrieta, Oscar Arrieta   +9 more
doaj   +1 more source

Electronegative low density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved[S]

Journal of Lipid Research, 2016
Dyslipidemia has been proven to capably develop and aggravate chronic kidney disease. We also report that electronegative LDL (L5) is the most atherogenic LDL.
Chao-Hung Chen, Liang-Yin Ke, Hua-Chen Chan, An-Sheng Lee, Kun-Der Lin, Chih-Sheng Chu, Mei-Yueh Lee, Pi-Jung Hsiao, Chin Hsu, Chu-Huang Chen, Shyi-Jang Shin   +10 more
doaj   +1 more source

Retinol and vitamin A metabolites accumulate through RBP4 and STRA6 changes in a psoriasis murine model

Nutrition & Metabolism, 2020
Background Psoriasis is a common chronic inflammatory skin disease that features the abnormal proliferation of keratinocytes. This proliferation could partly result from disturbances in vitamin A metabolism. Changes in psoriasis patients of the levels of
Hai-meng Wang, Chao Wu, Yan-yun Jiang, Wen-ming Wang, Hong-zhong Jin   +4 more
doaj   +1 more source

Midnolin‐proteasome pathway for protein degradation

MedComm, Volume 4, Issue 6, December 2023., 2023
Overexpression of immediate‐early genes (IEGs) has been linked to was associated with cancer progression and prognosis. In a recent study, Gu et al. reported the midnolin‐proteasome pathway, a novel ubiquitin‐independent proteasomal degradation.
Wei‐Lin Jin
wiley   +1 more source

STRA6 exerts oncogenic role in gastric tumorigenesis by acting as a crucial target of miR-873

Journal of Experimental & Clinical Cancer Research, 2019
Background Increasing evidence shows that stimulated by retinoic acid 6 (STRA6) participates in regulating multiple cancers. However, the biological roles of STRA6 in gastric cancer (GC) remain unknown.
Linling Lin, Jian Xiao, Liang Shi, Wangwang Chen, Yugang Ge, Mingkun Jiang, Zengliang Li, Hao Fan, Li Yang, Zekuan Xu   +9 more
doaj   +1 more source

Follicle-stimulating hormone (FSH) promotes retinol uptake and metabolism in the mouse ovary

Reproductive Biology and Endocrinology, 2018
Background Retinoids (retinol and its derivatives) are required for the development and maintenance of normal physiological functions of the ovary.
Zhuo Liu, Yongfeng Sun, Yanwen Jiang, Yuqiang Qian, Shuxiong Chen, Shan Gao, Lu Chen, Chunjin Li, Xu Zhou   +8 more
doaj   +1 more source