Results 11 to 20 of about 62,019,121 (120)

Beyond a gatekeeper: the non-classical signaling role of STRA6 in driving endothelial senescence and atherosclerosis [PDF]

Frontiers in Immunology
Endothelial cell (EC) senescence is a fundamental driver of atherosclerosis. This review posits that the primary pathogenic role of Stimulated by Retinoic Acid 6 (STRA6) in the endothelium is not its canonical vitamin A transport but its non-classical ...
Yong Yuan, Jia Wang, Yunfang Zhang, Yan Yu, Weicheng Shi, Sulian Chen, Ye Kuang, Lei Feng   +7 more
doaj   +3 more sources

Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age [PDF]

JCI Insight
Adult stem cells decline in number and function in old age, and identifying factors that can delay or revert age-associated adult stem cell dysfunction are vital for maintaining a healthy lifespan.
Paula M. Fraczek, Pamela Duran, Benjamin A. Yang, Valeria Ferre, Leanne Alawieh, Jesus A. Castor-Macias, Vivian T. Wong, Steve D. Guzman, Celeste Piotto, Klimentini Itsani, Jacqueline A. Larouche, Carlos A. Aguilar   +11 more
doaj   +3 more sources

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury [PDF]

Cell Proliferation, Volume 59, Issue 7, July 2026.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +2 more sources

Vitamin A deficiency attenuates cardiac rupture in <i>Stra6-</i>deficient hearts following ischemic injury. [PDF]

Front Cardiovasc Med
Background: Stimulated by retinoic acid gene 6 (STRA6) is a cell surface receptor that regulates cellular uptake of vitamin A metabolites and cardiac development.
Smolenski Y, Froese N, Galuppo P, Werlein C, Gigina A, Talbot SR, Erschow S, Wedekind D, Geffers R, Ghyselinck NB, Bähre H, Kamp JC, Neubert L, Ricke-Hoch M, Bauersachs J, Riehle C.   +15 more
europepmc   +2 more sources

Role of stimulated by retinoic acid 6 in 46 children of coarctation of the aorta. [PDF]

Heliyon
(1) ObjectiveCoarctation of the aorta (CoA) is a complex congenital heart disease. Research on differential genes in patients with CoA and other groups of aortas and investigating the pathogenesis of aorta coarctation is essential for prevention and ...
Jin X, Pan Z, Zhao Z, Ouyang D, Qin J, Tian J.   +5 more
europepmc   +2 more sources

Loss of the vitamin A receptor RBPR2 in mice disrupts whole‐body retinoid homeostasis and the quantitative balance regulating retinylidene protein synthesis [PDF]

The FASEB Journal, Volume 39, Issue 5, 15 March 2025.
Schematic representation outlining the proposed role of the vitamin A receptor RBPR2 in maintaining whole‐body retinoid homeostasis. Abstract The distribution of stored dietary vitamin A/all‐trans‐retinol (ROL) from the liver throughout the body is critical for maintaining retinoid function in peripheral tissues and for generating visual pigments for ...
Rakesh Radhakrishnan, Matthias Leung, Anjelynt Lor, Swati More, Glenn P. Lobo   +4 more
wiley   +2 more sources

RBP4 promotes denervation‐induced muscle atrophy through STRA6‐dependent pathway [PDF]

Journal of Cachexia, Sarcopenia and Muscle, Volume 15, Issue 4, Page 1601-1615, August 2024.
Abstract Backgrounds Fat infiltration of skeletal muscle has been recognized as a common feature of many degenerative muscle disorders. Retinol binding protein 4 (RBP4) is an adipokine that has been demonstrated to be correlated with the presence and severity of sarcopenia in the elderly.
Kang‐Zhen Zhang, Jia‐Wen Li, Jin‐Shui Xu, Zheng‐Kai Shen, Yu‐Shuang Lin, Can Zhao, Xiang Lu, Yun‐Feng Rui, Wei Gao   +8 more
wiley   +2 more sources

Cosmetic retinoid use in photoaged skin: A review of the compounds, their use and mechanisms of action [PDF]

International Journal of Cosmetic Science, Volume 47, Issue 1, Page 45-57, February 2025.
This article reviews the cosmetic use of retinoid compounds for improving signs of photoaging. Retinoids, via a complex signalling pathway, can remodel the epidermis and dermis leading to an improved clinical and histological appearance of the skin. (Created with Biorender.com).
Bezaleel Mambwe, Kieran T. Mellody, Orsolya Kiss, Clare O'Connor, Mike Bell, Rachel E. B. Watson, Abigail K. Langton   +6 more
wiley   +2 more sources

Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies [PDF]

Immunity, Inflammation and Disease, Volume 12, Issue 10, October 2024.
RA has a pivotal role in maintaining the balance of Th17‐Treg cells and is also indispensable for appropriate responses of T helper (Th) cells. Recent evidence has depicted that RA levels are reduced in asthma and allergies and that treatment with RA alleviates allergy symptoms and airway inflammation.
Ramin Lotfi
wiley   +2 more sources

STRA6 is Differentially Expressed by Human PBMC Subsets [PDF]

, 2019
Stimulated by retinoic acid 6 (STRA6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol ...
Barrett, Crisha Brooks
core   +7 more sources