Correction: STRA6 polymorphisms are associated with EGFR mutations in locally-advanced and metastatic non-small cell lung cancer patients [PDF]
Frontiers in OncologySaé Muñiz-Hernández +9 more
doaj +2 more sources
Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage.
, 2013 Stra6 is the retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding protein. This transmembrane protein mediates the internalization of retinol, which then upregulates RA-responsive genes in target cells.
Salvador Macip (565581) +6 more
core +7 more sources
The Interactions for the RBP Receptor, Stimulated by Retinoic Acid Gene 6 [PDF]
, 2013 Vitamin A, or retinol, is a fat-soluble vitamin, essential for many important processes including proliferation, reproduction, vision and immunocompetence.
McQuaid, Kate
core +3 more sources
1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. [PDF]
, 1996 1,25 (OH)(2) Vitamin D-3 (VD3) and retinoic acid (RA) function as ligands for nuclear receptors which regulate transcription, Though the cardiovascular system is not thought to represent a classical target for these ligands, it is clear that both cardiac
Gardner, D. G. +7 more
core +1 more source
STRA6 and Placental Retinoid Metabolism in Gestational Diabetes Mellitus [PDF]
, 2021 Background: Recent reports indicate the potential role of the stimulated by retinoic acid 6 (STRA6) protein in developing insulin resistance. The study’s objective was to assess placental STRA6 expression and staining pattern in human pregnancy ...
Lorenza Driul +7 more
core +2 more sources
Structural and functional characterization of the retinol-binding protein receptor STRA6 [PDF]
, 2021 Vitamin A is an essential nutrient; it is not synthesized by mammals and therefore must be obtained through the diet. During times of fasting or dietary vitamin A insufficiency, retinol, the alcohol form of the vitamin is released from the liver, its ...
Costabile, Brianna Kay
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho +6 more
wiley +1 more source
p300 editing affects Wnt and retinoic acid signaling interactions.
, 2018 A. Wnt3a and all-trans retinoic acid (ATRA), individually, induced Stra6 (stimulated by retinoic acid 6) mRNA expression in both wild type (WT) and p300 edited P19 cells, as assessed by realtime RTPCR.
Cu Nguyen (458023) +6 more
core +1 more source
Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant
British Journal of Pharmacology, EarlyView.Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source