Results 41 to 50 of about 62,019,121 (120)

A schematic pathway indicating the interaction of retinoic acid metabolising enzymes in normal and metastatic colorectal cancer cells.

, 2014
A. CYP26A1, CYP26B1 and LRAT expression are low in normal cells which result in the “correct” amount of retinoic acid and expression of retinoic acid target genes to maintain and promote normal cell growth and differentiation. B.
Graeme I. Murray (195455), Gordon T. Brown (532127), Daniela Blihoghe (472704), Petronella Johansson (532129), Beatriz Gimenez Cash (532128), Ayham Alnabulsi (532130)   +5 more
core   +1 more source

Rescue of the Stargardt Disease Phenotype in Abca4 Knockout Mice Through Dietary Modulation of the Vitamin A Receptor RBPR2

FASEB BioAdvances, Volume 7, Issue 8, August 2025.
Genetics and the diet attenuate ocular lipofuscin production and accumulation and improves visual and RPE function in Abca4−/− mice. Abca4−/− mice supplemented with β‐carotene (BC) diet showed an increase in BC concentrations and retinoic acid metabolites in the liver, which led to an induction of hepatic Rbpr2 gene activity via RAR and RXR regulatory ...
Rakesh Radhakrishnan, Matthias Leung, Drew Yochim, Heidi Roehrich, Scott W. McPherson, Glenn P. Lobo   +5 more
wiley   +1 more source

Retinoic acid signalling in urinary bladder cancer

, 2022
Rak sečnega mehurja je deseti najpogostejši rak na svetu z visoko stopnjo ponovljivosti. Epidemiološke študije so pokazale, da povišan vnos vitamina A s prehrano zmanjša tveganje za razvoj raka mehurja.
Mišmaš Zrimšek, Maruša
core  

Quantification of All‐Trans Retinoic Acid and Cytokine Levels After Fungal, Viral and Bacterial Infections in the Lung

Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.
ABSTRACT All‐trans retinoic acid (atRA) plays a critical role in tissue homeostasis as a master regulator of cellular proliferation, apoptosis and differentiation as well as in immune cell differentiation and function. An active metabolite of vitamin A, atRA has been reported to be reduced in a number of inflammatory conditions in both the lung and gut.
Samuel A. Krug, Ravineel Singh, Jianshi Yu, William T. Witt, Nageswara R. Pilli, Angela Wilks, Mariette Barbier, Keven M. Robinson, Maureen A. Kane   +8 more
wiley   +1 more source

STRA6 is critical for cellular vitamin A uptake and homeostasis. [PDF]

, 2014
Vitamin A must be adequately distributed within the body to maintain the functions of retinoids in the periphery and chromophore production in the eyes.
Von Lintig, Johannes, Palczewski, Krzysztof, Kemerer, Mary, Maeda, Tadao, Amengual, Jaume, Zhang, Ning   +5 more
core   +1 more source

Scientific opinion on the tolerable upper intake level for preformed vitamin A and β‐carotene

EFSA Journal, Volume 22, Issue 6, June 2024.
Abstract Following two requests from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the revision of the tolerable upper intake level (UL) for preformed vitamin A and β‐carotene. Systematic reviews of the literature were conducted for priority adverse health effects
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan de Henauw, Karen‐Ildico Hirsch‐Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Georg Lietz, Giovanni Passeri, Ionut Craciun, Lucia Fabiani, Zsuzsanna Horvath, Silvia Valtueña Martínez, Androniki Naska   +22 more
wiley   +1 more source

Retinoid Treatment for Oral Leukoplakia: Current Evidence and Future Development

Journal of Clinical Pharmacy and Therapeutics, Volume 2024, Issue 1, 2024.
Oral leukoplakia (OLK) is one of the most common oral potentially malignant disorders (OPMDs). Preventing malignant transformation is the main purpose of OLK treatment. The treatment approaches of OLK include surgery, chemotherapy, and other therapies, such as photodynamic therapy and CO2 laser.
Yuting Hu, Ying Wang, Ying Li, Xin Zeng, Jing Li, Yu Zhou, Qianming Chen, Muhammad Iqhrammullah   +7 more
wiley   +1 more source

Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth [PDF]

, 2015
We gratefully acknowledge financial support from the Wellcome Trust (Grant No. WT089803MA to J.M.L.) and the School of Medicine, University of St Andrews.Neurite growth is central to the formation and differentiation of functional neurons and recently ...
Mohammed Arastoo, John M. Lucocq, Hacker, Christian, Lucocq, John Milton, Arastoo, Mohammed, Popovics, Petra, Stewart, Alan J., Christian Hacker, Alan J. Stewart, Petra Popovics   +9 more
core   +1 more source

Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese [PDF]

, 2020
Stimulated by retinoic acid gene homolog 6 (STRA6) and retinoic acid receptor responder 2 (RARRES2) are candidate genes involved in the pathogenesis of type 2 diabetes mellitus (T2DM).
Yun-Xi Li, Han-Wei Huang, Bi-Yu Liang
core  

In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors [PDF]

, 2012
Adult human cardiac mesenchymal-like stromal cells (CStC) represent a relatively accessible cell type useful for therapy. In this light, their conversion into cardiovascular precursors represents a potential successful strategy for cardiac repair.
Andrea Barbuti (106295), A. Barbuti, Rossini, Alessandra, Simona Nanni, Nanni, Simona, Barbuti, Andrea, C. Gaetano, Meraviglia Viviana, Carlo Gaetano (110837), Meraviglia, Viviana, Capogrossi, Maurizio C., Pompilio Giulio, Gualtiero I Colombo, Angela Scavone, Simona Nanni (110816), Maurizio C Capogrossi, S. Nanni, Scavone Angela, Matteo Vecellio, Viviana Meraviglia (110811), DiFrancesco Dario, A. Scavone, Antonella Farsetti, Alessandra Rossini (110841), Viviana Meraviglia, Colombo Gualtiero I., Dario DiFrancesco, Pompilio, Giulio, Gaetano, Carlo, Vecellio, Matteo, Nanni Simona, Maurizio C. Capogrossi (103525), D. DiFrancesco, Giulio Pompilio (103510), Gaetano Carlo, Carlo Gaetano, Colombo, Gualtiero I., Vecellio Matteo, Farsetti Antonella, A. Farsetti, Angela Scavone (110822), M. Vecellio, Farsetti, Antonella, Barbuti Andrea, Capogrossi Maurizio C., Rossini Alessandra, G.I. Colombo, Giulio Pompilio, Antonella Farsetti (110827), V. Meraviglia, Alessandra Rossini, Andrea Barbuti, DiFrancesco, Dario, Dario DiFrancesco (106304), M. C. Capogrossi, Gualtiero I. Colombo (103516), Scavone, Angela, Matteo Vecellio (110807), A. Rossini, G. Pompilio   +59 more
core   +2 more sources