Results 31 to 40 of about 62,019,121 (120)

Osimertinib Resistance in EGFR‐Mutated Non–Small Cell Lung Cancer: Mechanisms and Therapeutic Strategies

MedComm, Volume 7, Issue 7, July 2026.
This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley   +1 more source

A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters [PDF]

, 2008
The nuclear retinoic acid (RA) receptor alpha (RARα) is a transcriptional transregulator that controls the expression of specific gene subsets through binding at response elements and dynamic interactions with coregulators, which are coordinated by
Christine Ferry, Hughes de The, Annie Bauer, Vanessa Duong, Cecile Rochette-Egly, Nathalie Bruck, Dominique Vitoux   +6 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk [PDF]

, 2011
Coordination between functionally related adjacent tissues is essential during development. For example, formation of trunk neural crest cells (NCCs) is highly influenced by the adjacent mesoderm, but the molecular mechanism involved is not well ...
Quiroga, Alejandra C, Kate G. Storey, Barbas, Julio A., Storey, Kate G, Morales, Aixa V., Alejandra C. Quiroga, Storey, Kate G., Das, R. M., Quiroga, Alejandra C., Barbas, Julio A, Aixa V. Morales, Raman M. Das, Das, Raman M., Morales, Aixa V, Olivera-Martinez, Isabel, Ruth Diez del Corral, Patricia L. Martínez-Morales, Julio A. Barbas, Martinez-Morales, Patricia L., Olivera-Martínez, I., Isabel Olivera-Martínez, Martínez-Morales, Patricia L, Diez del Corral, Ruth, Das, Raman M; id_orcid   +23 more
core   +1 more source

Plasma RBP4 Level in Association with Body Composition, Metabolic Profile, STRA6 and RBP4 Gene Polymorphisms in Obese Romanian Children

Diabetes, Metabolic Syndrome and Obesity, 2020
Anastasia Boaghi,1 Raluca-Monica Pop,1,2 Simona Loredana Vasilache,3 Claudia Banescu,4 Adina Hutanu,5 Oana Cristina Marginean,6 Ionela Maria Pascanu1,7 1Department of Endocrinology, Mures County Hospital, Tȃrgu Mureș 540139, Romȃnia; 2Research ...
Boaghi A, Pop RM, Vasilache SL, Banescu C, Hutanu A, Marginean OC, Pascanu IM   +6 more
doaj  

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Relationship Between Serum Metabolites of Carotenoids, Vitamin A, Vitamin E, and Clinical Parameters in COVID‐19 Patients

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Oxidative stress and inflammation play central roles in the immunopathogenesis of COVID‐19. In this study, we investigated whether circulating carotenoids, retinol, and vitamin E metabolites can distinguish COVID‐19 patients from healthy controls and discriminate disease severity.
Aysel Ozpinar, Ceyda Sonmez, Aleyna Baltacioglu, Osman Acar, Meltem Kilercik, Mustafa Cetiner, Mustafa Serteser, Jens Raila, Muhittin A. Serdar, Florian J. Schweigert, Sancha Vale   +10 more
wiley   +1 more source

Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship?

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
Circadian rhythm is offering novel insights into the pathogenesis of retinopathy. Bmal1, a key transcriptional regulator of the circadian clock, serves as a critical pathologic cofactor in retinal degeneration. Deficiency in Bmal1 contributes to a broad spectrum of retinal pathological alterations, and modulating the clock gene Bmal1 could potentially ...
Yongheng Cui, Haoyan Li, Wenhui Fan, Hao Wu, Jiale Wang, Chengkang Qu, Ning Pu, Ye Tao   +7 more
wiley   +1 more source

Pathogenesis of retinoic acid-induced spina bifida in rat embryos [PDF]

, 2008
In a previous study, we showed that the intrauterine exposure of rat embryos to retinoic acid (RA) in the organogenesis period (8-11 days of gestation) induced various malformations according to the dose and timing of RA administration.
コニシ, ヒロヨシ, 小西, 啓悦, 1430, Konishi, Hiroyoshi   +3 more
core   +1 more source

Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non‐genetic Model to Study Hirschsprung Disease?

Neurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
This study investigates the role of retinoic acid (RA) in intestinal development using the zebrafish. RA inhibition reduced enteric neurons and altered non‐neuronal cell populations. Compared to the ret mutant model, RA deficiency caused distinct shifts in epithelial, immune, and mesenchymal populations, highlighting RA's broader influence on ...
Naomi J. M. Kakiailatu, Wei Zhang, Laura E. Kuil, Eric Bindels, Joke T. M. Zink, Michael Vermeulen, Emma de Pater, Veerle Melotte, Maria M. Alves   +8 more
wiley   +1 more source