Methods to Discover and Evaluate Proteasome Small Molecule Stimulators
Molecules, 2019 Protein accumulation has been identified as a characteristic of many degenerative conditions, such as neurodegenerative diseases and aging. In most cases, these conditions also present with diminished protein degradation. The ubiquitin-proteasome system (
Rachel A. Coleman, Darci J. Trader
doaj +1 more source
Reduced Muscle Fatigue Using Continuous Subthreshold Kilohertz Stimulation of Peripheral Nerves [PDF]
arXivFunctional electrical stimulation (FES) is a prevalent technique commonly used to activate muscles in individuals with neurological disorders. Traditional FES strategies predominantly utilize low-frequency (LF) stimulation, which evokes synchronous action potentials, leading to rapid muscle fatigue.
arxiv
STUDIES ON THE MECHANISM OF ERYTHROPOIETIC STIMULATION IN PARABIOTIC RATS DURING HYPOXIA [PDF]
, 1950 Kurt R. Reißmann
openalex +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Tinnitus suppression by electric stimulation of the auditory nerve
Frontiers in Systems Neuroscience, 2012 Electric stimulation of the auditory nerve via a cochlear implant (CI) has been observed to suppress tinnitus, but parameters of an effective electric stimulus remain unexplored.
Janice Erica Chang +2 more
doaj +1 more source
WAND: A 128-channel, closed-loop, wireless artifact-free neuromodulation device [PDF]
arXiv, 2017 Closed-loop neuromodulation systems aim to treat a variety of neurological conditions by dynamically delivering and adjusting therapeutic electrical stimulation in response to a patient's neural state, recorded in real-time. Existing systems are limited by low channel counts, lack of algorithmic flexibility, and distortion of recorded signals from ...
arxiv
Visual stimulation and ovulation in pigeons [PDF]
, 1939 L. Harrison Matthews
openalex +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
The Application of Stimuli-Sensitive Actuators Based on Graphene Materials
Frontiers in Chemistry, 2019 Graphene-based materials that can spontaneously response to external stimulations have triggered rapidly increasing research interest for developing smart devices due to their excellent electrical, mechanical and thermal properties.
Jiangli Xue, Zhaoshun Gao, Liye Xiao
doaj +1 more source
Non-Invasive Temporal Interference Electrical Stimulation for Spinal Cord Injury Rehabilitation: A Simulation Study [PDF]
arXivBackground: Spinal cord injury (SCI) rehabilitation remains a major clinical challenge, with limited treatment options for functional recovery. Temporal interference (TI) electrical stimulation has emerged as a promising non-invasive neuromodulation technique capable of delivering deep and targeted stimulation.
arxiv