Results 31 to 40 of about 11,352 (215)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Aprendizagem de rudimentos de leitura musical com ensino cumulativo e não cumulativo de relações condicionais

Psicologia: Teoria e Pesquisa
RESUMO O estudo avaliou o efeito de treino cumulativo de relações condicionais sobre a aprendizagem de rudimentos de leitura musical. Os estímulos foram sequências de notas nas modalidades: sonora (A), notação em clave de sol (B) e figura de teclado (C).
Elenice S Hanna, Erick Rôso Huber, Paula Carvalho Natalino   +2 more
doaj   +1 more source

Vascular Risk Factors and Diseases Modulate Deficits of Reward-Based Reversal Learning in Acute Basal Ganglia Stroke. [PDF]

PLoS ONE, 2016
BACKGROUND:Besides motor function, the basal ganglia have been implicated in feedback learning. In patients with chronic basal ganglia infarcts, deficits in reward-based reversal learning have previously been described.
Ulla K Seidel, Janine Gronewold, Manon Wicking, Christian Bellebaum, Dirk M Hermann   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Emergência de relações numéricas sob controle condicional em crianças surdas

Psicologia: Teoria e Pesquisa
Os estudos sobre classes ordinais têm apresentado diversos achados experimentais para a compreensão das relações entre estímulos em seqüências. O objetivo do presente trabalho foi investigar se esses resultados seriam obtidos em crianças com surdez.
Ruth Daisy Capistrano de Souza, Grauben José Alves de Assis   +1 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Emergência de classes seqüenciais após treino com pareamento consistente

Psicologia: Teoria e Pesquisa
Relações de ordem podem ser documentadas por meio de testes comportamentais através das propriedades de assimetria, transitividade e conectividade. A emergência de classes seqüenciais pode ser estabelecidas de diferentes maneiras, inclusive a partir do ...
Mylena Pinto Lima, Grauben Assis
doaj   +1 more source

Exploring learning potential in schizophrenic inpatients in different psychopathological conditions [PDF]

Clínica y Salud. Investigación Empírica en Psicología, 2016
The aim of this paper is to explore empirically the learning potential of people with schizophrenia in opposite conditions of psychopathological stability.
David González Pando, Palma Beltrán García, Pedro Carlos Martínez Suárez   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source