Results 101 to 110 of about 233,089 (385)

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING [PDF]

, 2014
SummaryStimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for host immune responses triggered by microbial DNAs. However, the regulatory mechanisms underlying STING-mediated signaling are not fully understood.
Chen, Wei, Cui, Ye, Li, Senlin, Liu, Xing, Pan, Youdong, Tang, Yijun, Wang, Chen, Wang, Qiang, Yu, Huansha   +8 more
core   +1 more source

Structurally Colored Physically Unclonable Functions with Ultra‐Rich and Stable Encoding Capacity

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
This study reports a design strategy for generating bright‐field resolvable physically unclonable functions with extremely rich encoding capacity coupled with outstanding thermal and chemical stability. The optical response emerges from thickness‐dependent structural color formation in ZnO features, which are fabricated by physical vapor deposition ...
Abidin Esidir, Miaoning Ren, Sami Pekdemir, Mustafa Kalay, Nilgun Kayaci, Nail Gunaltay, Hakan Usta, Xian Huang, Mustafa Serdar Onses   +8 more
wiley   +1 more source

Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
By fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels, a new class of granular hydrogel scaffolds with hierarchical porosity is developed. These scaffolds have a significantly higher void fraction than their counterparts made up of nonporous microgels, enhancing cell recruitment and tissue integration. This research may
Alexander Kedzierski, Sina Kheirabadi, Arian Jaberi, Zaman Ataie, Catherine L. Mojazza, Marisa L. Williamson, Anton M. Hjaltason, Aneesh Risbud, Yuanhui Xiang, Amir Sheikhi   +9 more
wiley   +1 more source

Role and Mechanism of cGAS-STING Pathway in Cardiovascular System

Reviews in Cardiovascular Medicine
The cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system.
Xianqiang Yu, Silin Pan
doaj   +1 more source

Euscorpius (Scorpiones, Euscorpiidae): three cases of stings in northwestern Italy

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
In the period between June 2008 and August 2009, three cases of stings of Euscorpius scorpions indigenous to Italy were treated at two different emergency departments (ED) in hospitals of the Piedmont region, northwest Italy: Santa Croce e Carle General ...
M Dutto, L Dutto, N Scaglione, M Bertero
doaj   +1 more source

Ultra‐Fast Non‐Volatile Resistive Switching Devices with Over 512 Distinct and Stable Levels for Memory and Neuromorphic Computing

Advanced Functional Materials, EarlyView.
A materials and device design concept that comprises a self‐assembled ultra‐thin epitaxial ion‐transporting layer, an amorphous oxide overcoat oxygen‐blocking layer, and a partial filament formed during an electroforming step is proposed for low‐current multilevel resistive switching devices.
Ming Xiao, Markus Hellenbrand, Nives Strkalj, Babak Bakhit, Zhuotong Sun, Nikolaos Barmpatsalos, Dovydas Joksas, Hongyi Dou, Zedong Hu, Ping Lu, Samip Karki, Sundar Kunwar, Jonathan D. Major, Aiping Chen, Haiyan Wang, Quanxi Jia, Adnan Mehonic, Judith L. MacManus‐Driscoll   +17 more
wiley   +1 more source

LARP7 Contributes to Glucose-Induced Cardiac Dysfunction, Apoptosis and Fibrosis by Inhibiting the Degradation of STING

Frontiers in Bioscience-Landmark
Background: Diabetic cardiomyopathy (DCM) is an important cause of heart failure in diabetic patients. The aim of this study was to investigate the pathogenesis of DCM and to identify potential therapeutic targets.
Jingjing Sun, Ziming Wang, Yixuan Duan, Chang Liu, Sihai Zhao, Jie Deng   +5 more
doaj   +1 more source

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

OncoImmunology, 2018
Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer ...
Ellen C. Moore, Lillian Sun, Paul E. Clavijo, Jay Friedman, Joe B. Harford, Anthony D. Saleh, Carter Van Waes, Esther H. Chang, Clint T. Allen   +8 more
doaj   +1 more source

The sting is in the tale [PDF]

Current Biology, 2006
Research is driven as much by new technology as by new ideas. Just think of the way biology has changed out of all recognition during the last 35 years as a result of, amongst other things, DNA cloning, Southern blotting, microarrays, mass spectroscopy, and high throughput DNA sequencing.
openaire   +2 more sources

Analyzing Electronic Excitations and Exciton Binding Energies in Y6 Films

Advanced Functional Materials, EarlyView.
The Y6 molecule is used for increasing the efficiency of organic solar cells. The exciton binding energy is calculated for ensembles of Y6 molecules that are representative of the typically used films. The calculations show that the excitons typically spread out over many molecules.
Sahar Javaid Akram, Sophie Meißner, Stephan Kümmel   +2 more
wiley   +1 more source