Results 121 to 130 of about 409,058 (151)
Next-generation CAR-T engineering for colorectal cancer: integrating targets, tumor microenvironment barriers, and emerging strategies. [PDF]
Front ImmunolYang Y +6 more
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Chemical Communications, 2020
Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA) for cancer vaccine development. The immune responses against sTn have been significantly augmented with the involvement of Rha-specific antibodies to enhance antigen uptake.
Zhimeng Wu, Jinfeng Wang, Zhifang Zhou
exaly +3 more sources
Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA) for cancer vaccine development. The immune responses against sTn have been significantly augmented with the involvement of Rha-specific antibodies to enhance antigen uptake.
Zhimeng Wu, Jinfeng Wang, Zhifang Zhou
exaly +3 more sources
A rat model to study the role of STn antigen in colon cancer
Glycoconjugate Journal, 2001Expression of the mucin-associated sialyl-Tn (STn) antigen has been associated with a decreased survival in patients with colorectal, gastric, and ovarian cancer. To better understand the role of STn antigen in tumor biology, we developed STn(+) (called LP) and STn(-) (called LN) clonal cell lines from a parental metastatic rat colon carcinoma cell ...
Steven H Itzkowitz +2 more
exaly +3 more sources
ACS Chemical Biology, 2011
The abnormal glycans expressed on the surface of tumor cells, known as tumor-associated carbohydrate antigens, increase the chance to develop carbohydrate-based anticancer vaccines. However, carbohydrate antigens pose certain difficulties, and the major drawback is their weak immunogenicity.
Yue Wang, Xin-Shan Ye, Xiu-Jing Zheng
exaly +3 more sources
The abnormal glycans expressed on the surface of tumor cells, known as tumor-associated carbohydrate antigens, increase the chance to develop carbohydrate-based anticancer vaccines. However, carbohydrate antigens pose certain difficulties, and the major drawback is their weak immunogenicity.
Yue Wang, Xin-Shan Ye, Xiu-Jing Zheng
exaly +3 more sources
Tumor‐associated antigens: Tn antigen,
AbstractGlycosylation is one of the major posttranslational modifications of proteins. N‐glycosylation (Asn‐linked) and O‐glycosylation (Ser/Thr‐linked) are the two main forms. Abnormal O‐glycosylation is frequently observed on the surface of tumor cells, and is associated with an adverse outcome and poor prognosis in patients with cancer.
C, Fu +6 more
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Cancer Research, 2021
Abstract Targeting glyco-epitopes with antibody-drug conjugates (ADCs) provides a unique advantage as multiple cell surface proteins expressing the same carbohydrate can be harnessed to deliver drug. Sialyl-Thomsen nouveau (STn) is a tumor associated carbohydrate antigen that has historically been difficult to target with specificity ...
Alyssa Schwartz +9 more
openaire +1 more source
Abstract Targeting glyco-epitopes with antibody-drug conjugates (ADCs) provides a unique advantage as multiple cell surface proteins expressing the same carbohydrate can be harnessed to deliver drug. Sialyl-Thomsen nouveau (STn) is a tumor associated carbohydrate antigen that has historically been difficult to target with specificity ...
Alyssa Schwartz +9 more
openaire +1 more source
Construction and validation of a Sambucus nigra biosensor for cancer-associated STn antigen
Biosensors and Bioelectronics, 2014A label-free electrochemical impedance spectroscopy biosensor for selective detection and discrimination of the cancer-associated sialyl-Tn (STn) antigen was developed by using Sambucus nigra agglutinin type I (SNA-I) as the recognition element. The SNA-I biosensor was constructed by immobilizing the lectin on screen-printed gold electrodes.
M Luísa S, Silva +4 more
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Electroanalysis, 2021
AbstractFerrocene‐derivatives have a well‐defined electrochemical behaviour, which can be changed upon binding to other molecules (including nonelectroactive species), as the conjugate presents a slower diffusion to the electrode surface. Therefore, the binding event can be easily detected by monitoring the decrease in the current intensity of the ...
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AbstractFerrocene‐derivatives have a well‐defined electrochemical behaviour, which can be changed upon binding to other molecules (including nonelectroactive species), as the conjugate presents a slower diffusion to the electrode surface. Therefore, the binding event can be easily detected by monitoring the decrease in the current intensity of the ...
openaire +1 more source
Molecular Cancer Therapeutics, 2018
Abstract Background: Thomsen-nouvelle (Tn) and its sialylated form (sTn) are carbohydrate antigens reported to be present on a broad array of tumor types, including breast, lung, and ovarian, but are not found on the cell surface of normal tissues. Tn is a single sugar residue that is added to Ser or Thr residues during the first step of
G Jonah Rainey +6 more
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Abstract Background: Thomsen-nouvelle (Tn) and its sialylated form (sTn) are carbohydrate antigens reported to be present on a broad array of tumor types, including breast, lung, and ovarian, but are not found on the cell surface of normal tissues. Tn is a single sugar residue that is added to Ser or Thr residues during the first step of
G Jonah Rainey +6 more
openaire +1 more source
Clinical Cancer Research, 2018
Abstract Ovarian cancer is the leading cause of death from gynecologic malignancies in the U.S. The current standard of care is tumor debulking followed by chemotherapy. This treatment results in approximately 70% of patients achieving an initial complete clinical response.
Daniel T. Dransfield +7 more
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Abstract Ovarian cancer is the leading cause of death from gynecologic malignancies in the U.S. The current standard of care is tumor debulking followed by chemotherapy. This treatment results in approximately 70% of patients achieving an initial complete clinical response.
Daniel T. Dransfield +7 more
openaire +1 more source