Results 161 to 170 of about 9,882,534 (302)

Aging: damage accumulation versus increasing mortality rate [PDF]

If aging is understood as some process of damage accumulation, it does not necessarily lead to increasing mortality rates. Within the framework of a suggested generalization of the Strehler-Mildwan (1960) model, we show that even for models with ...
Maxim S. Finkelstein
core  

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Stochastic Mortality Model with Fractional Lévy Dynamics

A substantial body of empirical evidence suggests that stochastic mortality models ignoring long range dependence tend to underestimate life expectancy, which may lead to profound implications for pension schemes and funding arrangements. This paper addresses the modelling of stochastic mortality via a mixture of a fractional Lévy process and standard ...
Congxin He, Lilian Hu, Yue Kuen Kwok, Yifan Ye   +3 more
openaire   +2 more sources

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Dihydrotanshinone I Targets MIF to Inhibit GSK‐3β/β‐Catenin Axis‐Mediated Invasion and Metastasis in Gastric Cancer

Phytotherapy Research, EarlyView.
DHT directly binds to MIF and subsequently blunts AKT signaling, which restores the kinase activity of GSK‐3β. The reactivated GSK‐3β then promotes the phosphorylation (Ser33/37/Thr41) and proteasomal degradation of β‐catenin, thereby preventing its nuclear translocation and inhibiting the transcription of EMT‐related genes (e.g., Snail and Twist ...
Chuhang Wang, Xiaochen Ni, Yuyan Pan, Wei Fan, Jianing Guo, Kaiyuan Zhang, Mingsi Zhang, Linfeng Zheng, Yunhai Wei, Tao Jiang, Guangji Zhang   +10 more
wiley   +1 more source

Weibull Variational Autoencoder for Remaining Useful Life Prediction

Quality and Reliability Engineering International, EarlyView.
ABSTRACT Remaining useful life (RUL) prediction is a critical technology for preventing unexpected failures and reducing maintenance costs in modern industrial systems. However, traditional model‐based approaches are limited by the need for explicit mathematical modeling of degradation mechanisms, while data‐driven methods often require large‐scale ...
JunWoo Yu, Yoojin Jang, Kwanghui Shin, Jinsoo Jeong, Yong Soo Kim   +4 more
wiley   +1 more source

Correcting Left‐Truncation Bias in Weibull Reliability Analysis: Synthetic Data Validation for Electrical Utility Assets

Quality and Reliability Engineering International, EarlyView.
ABSTRACT Incomplete historical records in utility asset datasets frequently introduce left‐truncation bias, leading to distorted reliability estimates and suboptimal asset management decisions. This study presents a systematic framework for validating left‐truncation correction in Weibull reliability analysis using synthetic data representative of ...
Philip Sage, Muralitheran V. Kanagarajoo, Pushpitha Kalutara, Philip Kibet Langat   +3 more
wiley   +1 more source

Sustainable Development Solutions Network (SDSN) Reports Between 2018 and 2023: Malmquist Index Analysis for the Performance of OECD Countries

Sustainable Development, EarlyView.
ABSTRACT In 2015, the United Nations (UN) adopted the 17 Sustainable Development Goals (SDGs), calling for urgent action to end poverty, reduce inequality, and secure a sustainable future. Within this global agenda, the commitment of the Organization for Economic Co‐operation and Development (OECD) is particularly significant given its institutional ...
Mehmet Güray Ünsal, R. Arzu Kalemci, İhsan Alp, Altay Oğulcan Dalkılıç, Busra Agan Celik   +4 more
wiley   +1 more source

Dynamic Impact of Income Inequality on Environmental Quality in Malaysia: Insights for Climate Action Using a Stochastic Impacts by Regression on Population, Affluence, and Technology Framework

Sustainable Development, EarlyView.
ABSTRACT This study explores the dynamic influence of income inequality on environmental quality in Malaysia and offers evidence‐based recommendations for climate action and policy. Using annual data from 1990 to 2022, the analysis utilizes the Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT) framework combined with ...
Masahina Sarabdeen, Ahmad Mohammadi, Rafia Afroz, Hawazen Zam Almugren   +3 more
wiley   +1 more source

Finite-time stability of the West Nile Virus model with Brownian motion. [PDF]

PLoS One
Chang K.
europepmc   +1 more source