Results 41 to 50 of about 6,128,931 (296)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Past as a Stochastic Process

Journal of Computer Applications in Archaeology
20 pages, 4 ...
David H. Wolpert, Michael H. Price, Stefani A. Crabtree, Timothy A. Kohler, Jürgen Jost, James Evans, Peter F. Stadler, Hajime Shimao, Manfred D. Laubichler   +8 more
openaire   +4 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Wasserstein Kernel Regression with Dependent Distribution-Valued Predictors: Local Recurrence, Joint Inference, and Multivariate Gaussian Geometry

Mathematics
We study scalar nonparametric regression with a probability-measure-valued predictor observed along a dependent time series. A Nadaraya–Watson smoother localizes directly in the quadratic Wasserstein metric.
Wahiba Bouabsa, Fatimah Alshahrani
doaj   +1 more source

Combinatorial stochastic processes [PDF]

Stochastic Processes and their Applications, 1994
Well-known asymptotic results for sums of independent stochastic processes are extended to processes \(S = \sum^ n_{i = 1} \varphi_{i \pi (i)}\), where \(\varphi = (\varphi_{ij})_{1 \leq i,j \leq n}\) is a collection of independent stochastic processes \(\varphi_{ij}\) on some set \(\tau\), and \(\pi\) is a random permutation of \(\{1,2, \dots, n ...
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Robust Functional Regression via FPCA, Copula-Scale Design, and Multivariate Bernstein Smoothing

Mathematics
We introduce a robust nonparametric regression framework for functional covariates that combines functional principal component analysis (FPCA), marginal copula-scale normalization, bounded-score M-estimation, and multivariate Bernstein smoothing.
Wahiba Bouabsa, Fatimah Alshahrani
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Quantifying scrambling in quantum neural networks

Journal of High Energy Physics, 2022
We quantify the role of scrambling in quantum machine learning. We characterize a quantum neural network’s (QNNs) error in terms of the network’s scrambling properties via the out-of-time-ordered correlator (OTOC).
Roy J. Garcia, Kaifeng Bu, Arthur Jaffe
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source