Results 51 to 60 of about 74,695 (306)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Loss of native brown trout diversity in streams of the continental Croatia

Frontiers in Environmental Science
Introduction: The genetic diversity of brown trout in the Western Balkans has been disrupted by the introduction of non-native Atlantic phylogenetic lineages and non-native haplotypes of the Danubian phylogenetic lineage.
Tamara Kanjuh, Ana Marić, Dubravka Škraba Jurlina, Predrag Simonović, Ivan Špelić, Marina Piria, Marina Piria, Ivana Maguire   +7 more
doaj   +1 more source

FACTORS INFLUENCING OPTIMAL STOCKING RATES FROM A TENANT PERSPECTIVE [PDF]

The terms of grazing lease contracts potentially influence the tenants incentive to preserve the vegetation resource. Annual stocking rate decisions dictate the degree of overgrazing, which can be cumulative over long periods of time.
Langemeier, Michael R., Dhuyvetter, Kevin C., Jones, Rodney D., May, Gary J.   +3 more
core  

The translocation of golden perch, Murray cod and Australian bass, into and within Western Australia, for the purposes of recreational stocking, domestic stocking and commercial and non-commercial aquaculture [PDF]

, 2003
This discussion paper has been prepared to provide information to assist in assessment of the possible impact of the translocation of golden perch (Macquaria ambigua), Murray cod (Maccullochella peelii peelii) and Australian bass (Macquaria novemaculeata)
Hambleton, S., Ginbey, B., Humphries, P., Pen, L., Looby, G., Sarre, G., Chalmers, C., Cribb, A., Machin, D., Jones, B., Gill, H., Morgan, D., Thurstan, S., Lenanton, R., Molony, B., Astbury, C., Rowland, S., Thorne, T., Bardsley, B., McCrea, J.   +19 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Nursery and grow-out operation and management of milkfish [PDF]

, 1988
This paper reviews the results of studies on the pond culture of milkfish Chanos chanos Forsskal at the SEAFDEC Leganes Brackishwater Station, Leganes, Iloilo since its establishment in 1973.
Gerochi, Dante D., Bombeo-Tuburan, Isidra.   +1 more
core   +1 more source

Lake Michigan Salmonid Stocking Costs in Wisconsin [PDF]

The costs of stocking salmonids in the Wisconsin waters of Lake Michigan are estimated for 1985. Estimation procedures and costs per stocked and captured fish are presented. Fingerlings of a species were found in most cases to cost more per captured fish
Ives, David B., Cochrane, Jeffrey A., Bishop, Richard C.   +2 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source