Results 81 to 90 of about 1,092,982 (283)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Food and feeding habits of Synodontis nigrita from the Osun River, SW Nigeria [PDF]

An investigation was conducted into the food and feeding habits of Synodontis nigrita from the Osun River near Epe, Lagos, Nigeria. The food items in the stomach of the S.
Olojo, E.A.A., Olurin, K.B., Osikoya, O.J.   +2 more
core  

Yunweiling alleviates functional constipation: integrating network pharmacology and experimental study

Animal Models and Experimental Medicine
Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional Constipation (FC) using network pharmacology and experimental research.
Peng Zhang, Wei Li, Weiwen Zheng, Jinwen Liu, Nuonan She, Xia Chen, Weibo Wen   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients [PDF]

, 2015
Background and Objective: Helicobacter pylori is the main gastric pathogen in human. BabA2 and Hsp genotypes are essential for enormous clinical outcomes in gastreodeoneal and dyspepsia.
Azarhoush, R., Azarhoush, R., Forghanifar, M., Heidari, K.   +3 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Metastatic tumors to the stomach: clinical and endoscopic features. [PDF]

, 2006
AIM: To evaluate the clinical and endoscopic patterns in a large series of patients with metastatic tumors in the stomach. METHODS: A total of 64 patients with gastric metastases from solid malignant tumors were retrospectively examined between 1990 and ...
DE PALMA, GIOVANNI DOMENICO, I. Simeoli, L. Iannone, M. Donisi, M. Rega, MASONE, STEFANIA, P. Addeo, PERSICO, GIOVANNI, V. Pilone   +8 more
core  

Oncologic outcomes of patients with negative nodal involvement on preoperative imaging undergoing surgery for gastric cancer

World Journal of Surgical Oncology
Background Preoperative assessment of lymph node status is crucial in guiding treatment decisions for gastric cancer (GC) patients. However, it may not always accurately detect occult lymph node metastasis (OLNM).
Zhizhong Xiong, Jia Bo Zheng, Bin Zhong, Huashe Wang, Jintuan Huang, Lei Lian   +5 more
doaj   +1 more source

The effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis

Frontiers in Nutrition
BackgroundThe incidence of NAFLD is increasing. Preclinical evidences indicate that modulation of the gut microbiome could be a promising target in nonalcoholic fatty liver disease.MethodA systematic review and network meta-analysis was conducted to ...
Yijia Song, Yijia Song, Yijia Song, Sutong Liu, Lihui Zhang, Lihui Zhang, Wenxia Zhao, Yuanmei Qin, Yuanmei Qin, Minghao Liu   +9 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source