Results 81 to 90 of about 626,150 (309)

Gastrointestinal health anti-diarrheal mixture relieves spleen deficiency-induced diarrhea through regulating gut microbiota

Open Life Sciences
This study evaluated the therapeutic efficacy of the gastrointestinal health anti-diarrheal mixture (GHAM) on diarrhea induced by spleen deficiency, focusing on its modulation of gut microbiota.
Wu Zhengquan, Yao Liuyi, Guo Jun, Xu Zhong, Wang Zhengyan   +4 more
doaj   +1 more source

Global research trends in signaling pathways of spasmolytic polypeptide-expressing metaplasia pathogenesis: a bibliometric analysis

Frontiers in Oncology
BackgroundSignaling pathways associated with spasmolytic polypeptide-expressing metaplasia (SPEM) pathogenesis play a critical role in disease development, particularly in gastric cancer precursor lesions.
Qiumiao Xu, Qiumiao Xu, Zhijiang Dai, Zhijiang Dai, Chengjin Peng, Chengjin Peng, Qinghong Yan, Qinghong Yan, Xiaoting Chen, Xiaoting Chen, Tongwei Liu, Tongwei Liu, Ran Zhang, Guoxin Huang, Xinyao Liu, Jingbin Wang   +15 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Yunweiling alleviates functional constipation: integrating network pharmacology and experimental study

Animal Models and Experimental Medicine
Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional Constipation (FC) using network pharmacology and experimental research.
Peng Zhang, Wei Li, Weiwen Zheng, Jinwen Liu, Nuonan She, Xia Chen, Weibo Wen   +6 more
doaj   +1 more source

Unusual Surgical Repair of Bronchoesophageal Fistula Following Esophagectomy

Diagnostics
Radical esophagectomy remains the only potentially curative option in the treatment of esophageal cancer. However, this procedure is burdened with high morbidity and mortality rates, even in high-volume centers.
Predrag Sabljak, Ognjan Skrobic, Aleksandar Simic, Keramatollah Ebrahimi, Dejan Velickovic, Vladimir Sljukic, Nenad Ivanovic, Milica Mitrovic, Jelena Kovac   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Food and feeding habits of Synodontis nigrita from the Osun River, SW Nigeria [PDF]

An investigation was conducted into the food and feeding habits of Synodontis nigrita from the Osun River near Epe, Lagos, Nigeria. The food items in the stomach of the S.
Olojo, E.A.A., Osikoya, O.J., Olurin, K.B.   +2 more
core  

Difference in the risk of gastrointestinal manifestations between peritoneal and hemodialysis patients: a systematic review and meta-analysis [PDF]

PeerJ
Objective A large number of patients on dialysis have gastrointestinal (GI) manifestations. However, it remains unclear whether dialysis modality affects their prevalence.
Jiaoyan Li, Jie Liang, Xiaoshuang Shi, Wenjie Lu   +3 more
doaj   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source