Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron +12 more
wiley +1 more source
Examining Electronic Health Records to Investigate Sex Differences in Oral Diseases and Conditions
ABSTRACT Objectives Sexual dimorphism has been shown to influence disease predisposition and/or progression, although population‐based studies in dental, oral, and craniofacial (DOC) diseases and conditions are limited. This study aimed to identify sex‐based differences in DOC diseases/conditions using two large health data repositories.
Emma Fetchko +2 more
wiley +1 more source
Editorial: Methods in experimental pharmacology 2023
Somasundaram Arumugam +2 more
doaj +1 more source
ABSTRACT Background and Aim Maple Syrup Urine Disease (MSUD) is a metabolic disorder affecting branched‐chain amino acid metabolism. While neurological symptoms are well‐characterized, cutaneous manifestations such as acrodermatitis dysmetabolica (AD) caused by isoleucine deficiency remain underrecognized.
Bahareh Abtahi‐naeini +4 more
wiley +1 more source
How Nutrient Deficiencies Impact the Oral Mucosa and How to Manage Them: A Narrative Review. [PDF]
Starzyńska P +3 more
europepmc +1 more source
Mucosal‐Associated Invariant T Cells in Health and Disease
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao +5 more
wiley +1 more source
Treatment Approaches for Therapy-Associated Mucosal Lesions in Pediatric Oncohematology Patients: Findings from a Retrospective Observational Study in an Italian Pediatric Hospital. [PDF]
Nicolosi B +11 more
europepmc +1 more source
Anamnesis of children suffering from herpetic stomatitis
The anamnestic data of children suffering from acute and recurrent herpetic stomatitis are analyzed in this article. The influence of different pathologic factors which can lower children's organism resistance and facilitate a manifestation of recurrent ...
I A Kazantseva
core
Patch Test Reactions to Dental Materials: A Retrospective Single‐Centre Study
In this retrospective single‐centre study of 439 adults referred for suspected delayed‐type hypersensitivity to dental materials, 50.1% had at least one positive patch test reaction, most often to metals. Nickel (23.0%) and palladium (16.6%) pre‐dominated, whilst methacrylate positivity was uncommon (6.2%) and not fully captured by HEMA alone.
Mojca Bizjak‐Suran +3 more
wiley +1 more source
Evaluation of the Antimicrobial Effect of Silver Nanoparticles Incorporated Into Heat-Cured Acrylic Denture Base Resin: A Clinical Study. [PDF]
Kaur S +5 more
europepmc +1 more source

