Results 171 to 180 of about 89,775 (291)
Efficacy and Safety of Lucitanib in Advanced Thymic Carcinoma: A Randomized Phase II Trial
MedComm, Volume 7, Issue 11, November 2026.In this randomized phase II trial, 68 patients with advanced thymic carcinoma after chemotherapy received lucitanib (n = 46) or placebo (n = 22). Median PFS was 5.8 versus 3.7 months by IRC (HR: 0.60; p = 0.105) and 6.6 versus 1.9 months by investigators (HR: 0.53; p = 0.031). Hypertension was the most common grade 3 TRAE (50%).
Wentao Fang +21 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.This case report describes an aggressive gingival extramedullary plasmacytoma (EMP) with regional lymph node metastasis in a 14‐year‐old cat. As complete surgical excision was unfeasible, three weekly electrochemotherapy (ECT) sessions using intravenous bleomycin were performed for local tumour control.
Seulgi Hwang +5 more
wiley +1 more source
Journal of Oral Rehabilitation, Volume 53, Issue 11, Page 2053-2063, November 2026.In this exploratory case–control study, plasma PLP (vitamin B6), homocysteine and ACTH concentrations did not differ between patients with burning mouth syndrome (BMS) and controls, and none discriminated patients individually. Within patients, however, psychological distress mapped onto a homocysteine–ACTH relationship from which PLP appeared ...
Ashley Lebel +3 more
wiley +1 more source
Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors
ChemMedChem, Volume 21, Issue 19, 14 October 2026.We designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Marco Minneci +6 more
wiley +1 more source
FEBS Letters, Volume 600, Issue 19, Page 2917-2928, October 2026.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
The Impact of SF3B1 Mutations on the Tumor Microenvironment and Response to Immunotherapy
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Cancer genomes shape the immune landscape within the tumor microenvironment (TME), thereby influencing host antitumor immunity. Identifying somatic mutations that modulate the TME is critical for selecting patients most likely to benefit from immunotherapy.
Kyung‐Jin Cho, Byungho Lim
wiley +1 more source
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Purpose The optimal chemotherapy strategy after progression on cyclin‐dependent kinase 4/6 inhibitors (CDK4/6i) in hormone receptor‐positive/human epidermal growth factor receptor 2‐negative (HR+/HER2−) metastatic breast cancer remains a matter of controversy.
Lara Laini +11 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Dietary and nutritional interventions have gained popularity among patients with cancer undergoing treatment due to the high cost of medical treatment and increased health awareness. Diet, nutrition, psychological stress, and adverse events during treatment have a significant impact on the quality of life of patients with cancer ...
Ken Yamaguchi +13 more
wiley +1 more source