Results 111 to 120 of about 270,897 (278)

Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

Cells, 2019
In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′−5′ mRNA interactions as ...
Barbara Gorgoni, Yun-Bo Zhao, J. Krishnan, Ian Stansfield   +3 more
doaj   +1 more source

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization [PDF]

, 1987
Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasminogen activator (t-PA) and u-PA have been designed to direct the synthesis of new plasminogen activators and to investigate the structure-function ...
Andre, B., Bollen, A., Collen, D., Cravador, A., Deforesta, F., Dewilde, M., Gheysen, D., Herzog, A., Hoylaerts, M., Jacobs, P., Pierard, L., Topisirovic, L.   +11 more
core   +1 more source

Control of ribosome traffic by position-dependent choice of synonymous codons

, 2013
Messenger RNA encodes a sequence of amino acids by using codons. For most amino acids there are multiple synonymous codons that can encode the amino acid.
Mitarai, Namiko, Pedersen, Steen
core   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

The complete mitochondrial genome of Apriona swainsoni

Mitochondrial DNA. Part B. Resources, 2019
Whole mitochondrial genome sequence of Apriona swainsoni has a circular genome of 15,412 bp. The contents of A, G, T, and C are 38.90%, 9.29%, 35.81%, and 15.99%, respectively. The proportion of coding sequences with a total length of 11, 141 bp is 72.29%
Shengquan Que, Ailin Yu, Peng Liu, Mingxia Jin, Gu'ai Xie   +4 more
doaj   +1 more source

Prokaryotic post stop-codon sequences

, 2022
The invention relates to methods of modulating gene expression in prokaryotes. The invention further relates to a prokaryotic expression cassette, a method of expressing a protein of interest in a prokaryotic cell, and to a prokaryotic cell comprising the prokaryotic expression cassette according to the invention.
Nieuwkoop, Thijs, Creutzburg, Sjoerd Constantijn Arnoud, Van Der Oost, John   +2 more
openaire   +1 more source

Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of Diaphorina citri to the Citrus Greening Pathogen, Candidatus Liberibacter Asiaticus

Advanced Science, EarlyView.
This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu, Qingcui He, Zeyue Lin, Shixuan Huang, Zichun Zhong, Pingyang Zhu, Mengge Gao, Luyao Zhao, Han Jin, Guiting Wu, Gurr M. Geoff, Qunxin Han, Rui Pang   +12 more
wiley   +1 more source

Characterization of complete mitochondrial genome of a new identification of Gymnothorax minor (Temminck & Schlegel, 1846) in China

Mitochondrial DNA. Part B. Resources, 2019
Gymnothorax minor has been often confused with G. reticularis because of the similar morphological characteristics. The complete mitochondrial genome sequence of G. minor is 16,575 bp in length, including 13 protein-coding genes, two ribosomal RNA genes,
Liyan Zhang, Zhidong Zhou, Shiquan Chen, Haiping Li, Yueping Zhang   +4 more
doaj   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. [PDF]

, 2019
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA).
Blanchard, Scott C, Calvert, Meredith E, Chen, Bin, Contreras, Adrian, Forester, Craig M, Gill, Ryan M, Gordan, John D, Holm, Mikael, Jackson, Cody, Kelley, R Kate, Luk, John M, McMahon, Mary, Pang, Xiaming, Quigley, David A, Ruggero, Davide, Uechi, Tamayo   +15 more
core   +1 more source