Results 121 to 130 of about 270,897 (278)

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

A Concept for Selection of Codon-Suppressor tRNAs Based on Read-Through Ribosome Display in an In Vitro Compartmentalized Cell-Free Translation System

Journal of Nucleic Acids, 2012
Here is presented a concept for in vitro selection of suppressor tRNAs. It uses a pool of dsDNA templates in compartmentalized water-in-oil micelles.
Atsushi Ogawa, Masayoshi Hayami, Shinsuke Sando, Yasuhiro Aoyama   +3 more
doaj   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript

, 2011
The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the track.
Agirrezabala, Ajeet K. Sharma, Alberts, Antal, Arava, Arava, Basu, Chou, Chou, Chowdhury, Chowdhury, Ciandrini, Debashish Chowdhury, Derrida, Frank, Garai, Gilchrist, Guo, Hager, Hager, Harrington, Hirokawa, Hopfield, Ingolia, Kolomeisky, Krug, Lakatos, Lodish, MacDonald, MacDonald, Mikamo, Mukamel, Ninio, Noll, Popkov, Reynolds, Rich, Romero, Schadschneider, Schütz, Sharma, Sharma, Shaw, Shaw, Shaw, Spirin, Spirin, Thompson, Warner, Warner, Zhdanov, Zia, Zouridis   +52 more
core   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Characterization of the complete mitochondrial genome of the medical pipefish Doryichthys boaja Bleeker 1850

Mitochondrial DNA. Part B. Resources, 2018
In the present study, we reported the complete mitochondrial genome of medical pipefish Doryichthys boaja Bleeker 1850. The complete mitochondrial genome of D. boaja was 16,562 bp in length and had a base composition of A (31.10%), C (24.14%), G (14.36%),
Yun Fang, Lingyan Zhu, Meng Chen, Yuqing Ge, Guangji Zhang, Rubin Cheng   +5 more
doaj   +1 more source

Mutations in pre-core and basal-core promoter regions of hepatitis B virus in chronic HBV patients from Golestan, Iran [PDF]

, 2014
Objective(s): It has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC).
Bazouri, M., Ghaemi, A., Javid, N., Moradi, A., Tabarraei, A., Zhand, S.   +5 more
core   +2 more sources

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning?

Gut and Liver, 2013
Background/AimsGastrointestinal stromal tumors (GISTs) strongly express a receptor tyrosine kinase (RTK, c-KIT-CD117) harboring a KIT mutation that causes constitutive receptor activation leading to the development and growth of tumors; 35% of GISTs ...
doaj   +1 more source

The complete mitochondrial genome of Dermogenys pusilla (Beloniformes: Hemiramphidae) and phylogenetic studies of Beloniformes

Mitochondrial DNA. Part B. Resources, 2019
In this study, the complete mitochondrial genome of Dermogenys pusilla was firstly determined. The complete genome is 16,529 bp in length. It contains 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, a putative control region, and 1 origin of ...
Yifan Liu, Fang Meng, Xiaolong Yin, Youkun Huang, Kehua Zhu, Jianshe Zhang, Fei Jing, Liping Xia, Bingjian Liu   +8 more
doaj   +1 more source