Results 151 to 160 of about 7,802 (179)

mRNA-based immunotherapy platform targeting endometrial cancer. [PDF]

J Transl Med
Freyberg M, Dierks M, Nass N, George C, Geffken M, Ignatov A, Kalinski T, Ignatova Z.   +7 more
europepmc   +1 more source

Methanogenic archaea encoding Pyrrolysine maintain ambiguous amber codon usage. [PDF]

Proc Natl Acad Sci U S A
Shalvarjian KE, Chadwick GL, Pérez PI, Woods PH, Orphan VJ, Nayak DD.   +5 more
europepmc   +1 more source

Protein C-terminal variations impact proteostasis. [PDF]

Nat Commun
Chu CY, Hsu SY, Yeh CW, Yeh KH, Wang LC, Lee LT, Chen SC, Yu CH, Yen HS.   +8 more
europepmc   +1 more source

Prime editing-installed suppressor tRNAs for disease-agnostic genome editing. [PDF]

Nature
Pierce SE, Erwood S, Oye K, An M, Krasnow N, Zhang E, Raguram A, Seelig D, Osborn MJ, Liu DR.   +9 more
europepmc   +1 more source

Mutations in ribosomal protein uS5 alter translation fidelity and mutagenesis in <i>Pseudomonas putida</i>. [PDF]

J Bacteriol
Jürgenstein K, Ilves H, Luhaäär C, Brauer A, Remme J, Kivisaar M.   +5 more
europepmc   +1 more source

ENSURE: the encyclopedia of suppressor tRNA with an AI assistant. [PDF]

Nucleic Acids Res
Ouyang Z, Zhang Y, Feng F, Zeng X, Wu Q, Hafeez A, Teng W, Kong Y, Bu X, Sun Y, Li B, Wen Y, Lun ZR, Qu L, Feng X, Zheng L.   +15 more
europepmc   +1 more source

Identification of small molecules that enhance aminoglycoside-mediated suppression of <i>CFTR</i> and <i>NF1</i> nonsense mutations. [PDF]

Mol Ther Oncol
Sammons J, Chen J, Thrasher K, Fu L, Du M, Wen H, Bostwick JR, Vinson P, Moukha-Chafiq O, Augelli-Szafran C, Keeling KM, Wallis D, Kesterson RA, Rowe SM, Bedwell DM.   +14 more
europepmc   +1 more source

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Cancer syndromes and therapy by stop-codon readthrough

Trends in Molecular Medicine, 2012
Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising ...
Renata Bordeira-Carriço, Ana Paula Pêgo, Carla Oliveira   +2 more
exaly   +4 more sources

Readthrough of dystrophin stop codon mutations induced by aminoglycosides

Annals of Neurology, 2004
AbstractWe report the translational readthrough levels induced by the aminoglycosides gentamicin, amikacin, tobramycin, and paromomycin for eight premature stop codon mutations identified in Duchenne's and Becker's muscular dystrophy patients. In a transient transfection reporter assay, aminoglycoside treatment results show that one stop codon mutation
Kevin M Flanigan, John F Atkins
exaly   +3 more sources

Mammalian proteome expansion by stop codon readthrough

WIREs RNA, 2022
AbstractRecognition of a stop codon by translation machinery as a sense codon results in translational readthrough instead of termination. This recoding process, termed stop codon readthrough (SCR) or translational readthrough, is found in all domains of life including mammals.
Lekha E. Manjunath, Anumeha Singh, Saubhik Som, Sandeep M. Eswarappa   +3 more
openaire   +2 more sources