Results 1 to 10 of about 28,342 (111)

Dual stop codon suppression in mammalian cells with genomically integrated genetic code expansion machinery [PDF]

Cell Reports: Methods, 2023
Summary: Stop codon suppression using dedicated tRNA/aminoacyl-tRNA synthetase (aaRS) pairs allows for genetically encoded, site-specific incorporation of non-canonical amino acids (ncAAs) as chemical handles for protein labeling and modification.
Birthe Meineke, Johannes Heimgärtner, Rozina Caridha, Matthias F. Block, Kyle J. Kimler, Maria F. Pires, Michael Landreh, Simon J. Elsässer   +7 more
doaj   +4 more sources

RNA Cis-Elements Involved in Animal Virus Stop Codon Readthrough: Stop Codon Context and Downstream RNA Structures [PDF]

Viruses
Stop codon readthrough is a noncanonical translation strategy employed by certain RNA viruses, in which a viral termination codon is either decoded by host near-cognate tRNAs or canonically recognized by the class I release factor (RF, eRF1 in eukaryotes)
Nobuhiko Kamoshita
doaj   +2 more sources

Correction to: In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study [PDF]

BMC Medicine, 2018
The original article [1] contains errors in Table 1 affecting some of the presented oligonucleotide sequences and readthrough values in Table 1.
I. Sermet-Gaudelus, M. Renouil, A. Fajac, L. Bidou, B. Parbaille, S. Pierrot, N. Davy, E. Bismuth, P. Reinert, G. Lenoir, J. F. Lesure, J. P. Rousset, A. Edelman   +12 more
doaj   +2 more sources

Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Dieter Söll, Yane-Shih Wang
exaly   +2 more sources

Two-Tier Screening Platform for Directed Evolution of Aminoacyl–tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency [PDF]

ChemBioChem, 2017
Rudi Fasan
exaly   +2 more sources

Genetic Code Expanded T Cell for Controllable Immunotherapy [PDF]

Advanced Science
Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application remains constrained by the risk of uncontrolled immune activation.
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
doaj   +2 more sources

Expanding the Range of Darobactin Derivatives by Amber Stop Codon Suppression To Introduce Non-canonical Amino Acids [PDF]

ACS Omega
Jil-Christine Kramer, Zerlina G. Wuisan, Ute Mettal, Michael Marner, Till F. Schäberle   +4 more
doaj   +2 more sources

Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis [PDF]

Signal Transduction and Targeted Therapy
Premature termination codons (PTCs) are a major class of pathogenic variants that underlie rare inherited disorders, including forms of childhood blindness.
Pawan K. Shahi, Enes Akyuz, Lionel Gissot, Ahmad Al Saneh, Sanjai K. Pillala, Divya Sinha, Giovanni M. Hanstad, Meha Kabra, Maria A. Fernandez Zepeda, David M. Gamm, Samuel M. Young, Christopher A. Ahern, Bikash R. Pattnaik   +12 more
doaj   +2 more sources

Stop Codon Context-Specific Induction of Translational Readthrough

Biomolecules, 2021
Premature termination codon (PTC) mutations account for approximately 10% of pathogenic variants in monogenic diseases. Stimulation of translational readthrough, also known as stop codon suppression, using translational readthrough-inducing drugs (TRIDs)
Mirco Schilff, Yelena Sargsyan, Julia Hofhuis, Sven Thoms   +3 more
doaj   +1 more source

Stop codon readthrough contexts influence reporter expression differentially depending on the presence of an IRES [version 3; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research, 2022
Background: Previously we reported the discovery of stop codon readthrough in AMD1 mRNA followed by ribosome stalling at the end of a conserved Open Reading Frame (ORF) that we termed AMD1.
Pavel V. Baranov, Martina M. Yordanova, John F. Atkins, Gary Loughran   +3 more
doaj   +1 more source